Study of the Influence of Bone Cement Type and Mixing Method on the Bioactivity and the Elution Kinetics of Ciprofloxacin

Martínez-Moreno, Javier; Mura, Carla; Merino, Virginia; Nácher, Amparo; Climente, M.; Merino-Sanjuán, Matilde

doi:10.1016/j.arth.2015.02.016

Cited by 20 publications

(10 citation statements)

References 34 publications

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“…We exchanged the PBS every day, but this does not reflect the actual physiologic environment of the bone and joint combined. Unlike joints, it is known that the cumulative concentration of drug released increases with time and remains high in bone, therefore daily replacement of PBS may not reflect this environment [30]. In future studies, the elution test should be designed to mimic the bone and joint environment.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have shown the effectiveness of antibiotic-loaded bone cement in pyogenic osteomyelitis [14,29,40,45], while other studies have shown the effectiveness of antibiotic-loaded bone cement in tuberculosis osteomyelitis or arthritis [20,25,32,42]. Furthermore, there is little information regarding combinations of antibiotics or their mixture ratios with bone cement [23,30,31,38].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

How Long Does Antimycobacterial Antibiotic-loaded Bone Cement Have In Vitro Activity for Musculoskeletal Tuberculosis?

Lee

Han

Cho

et al. 2017

Clinical Orthopaedics &Amp; Related Research

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

How Long Does Antimycobacterial Antibiotic-loaded Bone Cement Have In Vitro Activity for Musculoskeletal Tuberculosis?

Lee

Han

Cho

et al. 2017

Clinical Orthopaedics &Amp; Related Research

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“…Other antibiotics, under research, that have been mixed by some authors are ciprofloxacin, cefazolin, moxifloxacin, and amoxicillin clavulanate (Table ). Our research team examined ciprofloxacin release from three trademarks of bone cements (Simplex, Lima, and Palacos) and its bioactivity using as variables the mixing method, the chemical form of the antibiotic, and the antibiotic combination.…”

Section: Antibiotic Decisionsmentioning

confidence: 94%

“…A bioactivity simulation exercise showed that until 72 h post‐surgery, ciprofloxacin concentrations in the implant would be higher than 0.1 μg/mL in 100% of the patients. The limitations of this study are that no bending nor modulus strengths were calculated and the bioactivity was evaluated by means of a simulation exercise.…”

Section: Antibiotic Decisionsmentioning

confidence: 99%

Antibiotic‐loaded Bone Cement as Prophylaxis in Total Joint Replacement

Martínez-Moreno

Merino

Nácher

et al. 2017

Orthopaedic Surgery

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One of its most serious complications associated with arthroplasty is the development of infections. Although its prevalence is only between 0.5% and 3%, in some cases it can lead to death. Therefore, an important challenge in joint surgery is the prevention of infections when an arthroplasty is performed. The use of antibiotic-loaded cements could be a suitable tool due to numerous advantages. The main advantage of the use of antibiotic loading into bone cement derives directly from antibiotic release in the effect site, allowing achievement of high concentrations at the site of action, and minimal or no systemic toxicity. This route of administration was first described by Buchholz and Engelbrecht. In the case of infection treatment, this is an established method and its good results have been confirmed. However, its role in infection prevention, and, therefore, the use of these systems in clinical practice, has proved controversial because of the uncertainty about the development of possible antibiotic resistance after prolonged exposure time, their effectiveness, the cost of the systems, toxicity and loosening of mechanical properties. This review discusses all these topics, focusing on effectiveness and safety, antibiotic decisions, cement type, mixing method, release kinetics and future perspectives. The final objective is to provide the orthopaedic surgeons the right information in their clinical practice based on current evidence.

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“…An antibiotic to be mixed with the cement must be thermally stable with the exothermic reaction of polymerization, must not compromise the mechanical integrity of the cement and must elute from the cement for a certain period of time [7]. There are few studies regarding the mechanical properties of these cements mixed in the operating theatre [8,9], the majority of studies are targeted on the dose and time of local released antibiotic [10][11][12][13].…”

mentioning

confidence: 99%

Mechanical Behaviour of Orthopaedic Cement Loaded with Antibiotics in the Operation Room

Fleacă¹,

Mitariu²,

Oleksik³

et al. 2017

Mat.Plast.

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Using antibiotic impregnated cement is an important mean to treat and prevent periprostetic joint infections. This complication requires for treatment important financial and technical resources. Adding antibiotics to orthopaedic cement may alter its mechanical properties with possible reduced time of prosthesis survival rate. This study analyze the mechanical properties of cement mixed with antibiotics in the operation room, which helps reducing costs and permit a more specific antibiotic local therapy. All tested antibiotics used in this study does not change the mechanical behavior of the orthopaedic cement when mixed in therapeutic doses, all alterations seems to be at a level below clinical significance. Mixing antibiotics in Orthopedic cement leads to minor decrease of the mechanical properties for cefazolin, cefuroxime, ceftazidime, meropenem and vancomycin and a mechanical significant decrease for gentamicin and clindamycin.

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Study of the Influence of Bone Cement Type and Mixing Method on the Bioactivity and the Elution Kinetics of Ciprofloxacin

Cited by 20 publications

References 34 publications

How Long Does Antimycobacterial Antibiotic-loaded Bone Cement Have In Vitro Activity for Musculoskeletal Tuberculosis?

How Long Does Antimycobacterial Antibiotic-loaded Bone Cement Have In Vitro Activity for Musculoskeletal Tuberculosis?

Antibiotic‐loaded Bone Cement as Prophylaxis in Total Joint Replacement

Mechanical Behaviour of Orthopaedic Cement Loaded with Antibiotics in the Operation Room

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