Mechanical Behaviour of Orthopaedic Cement Loaded with Antibiotics in the Operation Room

Fleacă, Radu; Mitariu, Sebastian Ioan Cernusca; Oleksik, Valentin; Oleksik, Mihaela; Roman, Mihai Dan

doi:10.37358/mp.17.2.4860

Cited by 9 publications

(11 citation statements)

References 14 publications

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“…The brittle behaviour observed through bending tests of PMMA and PMMA-based composites, as well as bending modulus and strength (Figure 2a,b), is consistent with literature data reported for the Palamed bone cement [37]. On the other hand, the ductile behaviour in compression observed for PMMA and compression strength measurements (Figures 1b and 2c) are consistent with literature data reported for the stress vs. strain curves and strength of Palamed bone cement [28,29]. 2.5 wt % of CuTCP particles significantly increased the bending modulus of PMMA (p < 0.05).…”

Section: Discussionsupporting

confidence: 90%

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Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles

et al. 2019

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Cranioplasty represents the surgical repair of bone defects or deformities in the cranium arising from traumatic skull bone fracture, cranial bone deformities, bone cancer, and infections. The actual gold standard in surgery procedures for cranioplasty involves the use of biocompatible materials, and repair or regeneration of large cranial defects is particularly challenging from both a functional and aesthetic point of view. PMMA-based bone cement are the most widely biomaterials adopted in the field, with at least four different surgical approaches. Modifications for improving biological and mechanical functions of PMMA-based bone cement have been suggested. To this aim, the inclusion of antibiotics to prevent infection has been shown to provide a reduction of mechanical properties in bending. Therefore, the development of novel antibacterial active agents to overcome issues related to mechanical properties and bacterial resistance to antibiotics is still encouraged. In this context, mechanical, biological, and antibacterial feature against P. aeruginosa and S. aureus bacterial strains of surgical PMMA cement modified with BG and recently developed Cu-TCP bioactive particles have been highlighted.

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Section: Discussionsupporting

confidence: 90%

“…The loading of antibiotics (i.e., gentamicin) into PMMA has been suggested to prevent infection [21,27], but a reduction of mechanical properties has been observed in bending [20]. A decrease of the compressive yield stress of about 50% has been measured for gentamicin loaded bone cement at a concentration lower than 1 wt% [28,29].…”

Section: Introductionmentioning

confidence: 99%

Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles

et al. 2019

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“…Among them, gentamycin and clindamycin led to substantial decreases, resulting in failure to meet the threshold for weight-bearing use. [ 41 ] With drug particles gradually leaving the cement, the remaining gaps become weak points in the structure and lead to initiation of cracks. After 2 weeks of incubation at 37°C in natural saline, the impact strength of gentamycin/vancomycin-loaded ALBC decreased by nearly 40%.…”

Section: Mechanical Performance Of Albcmentioning

confidence: 99%

Progress of antibiotic-loaded bone cement in joint arthroplasty

Peng

Feng

et al. 2020

Chinese Medical Journal

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Bone cement, consisting of polymethyl methacrylate, is a bioinert material used for prothesis fixation in joint arthroplasty. To treat orthopedic infections, such as periprosthetic joint infection, antibiotic-loaded bone cement (ALBC) was introduced into clinical practice. Recent studies have revealed the limitations of the antibacterial effect of ALBC. Moreover, with the increase in high infection risk patients and highly resistant microbes, more researches and modification of ALBC are required. This paper reviewed latest findings about ALBC for most popular and destructive pathogens, summarized the influence of antibiotic kind, drug dosage, application method, and environment towards characteristic of ALBC. Subsequently, new cement additives and clinical applications of ALBC in joint arthroplasty were also discussed.

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“…This is attributed to cells need of communication that determines a distance reduction between them [13]. It is well known that if cells number in a population is not high enough and distance between them is too long, apoptosis takes place, especially when exposed to shear and mechanical stress [14]. Thus, higher length assures shorter distances between cells.…”

Section: Development Of Osteoblast Populations On Tissue Culture Polymentioning

confidence: 99%

A Step Forward Standardization of Biocompatibility Testing on Tissue Culture Polystyrene

Feier¹,

Manu²,

Strnad³

et al. 2018

Mat.Plast.

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Standard procedures regarding osteoblast cells deposition on different subtrates to test the biocompatibility of materials are not available. Aspects related to cells morphology depending on their number on the surface area of the substrate were studied for the first time. Osteoblasts were successfully isolated from residual bone resulted from two different patients after total hip arthroplasty. Different numbers of osteoblasts in populations (3x104 cells/cm2, 6x104 cells/cm2, 1x105 cells/cm2) were deposited on tissue culture polystyrene for 7 and 10 days of incubation. Results suggested that the protocol of osteoblasts deposition should be adjusted to assure a fair distribution of cells on the entire available area of the substrate, possible if a very good dispersion in the medium is achieved prior to deposition. Some other key factors in cells appropriate development, such as substrate nature, topography and incubation time,were detected. The present investigation helps declaring specific standards with respect to the biocompatibility testing of materials using osteoblast populations. Further investigations may lead to the creation of databases and the establishment of standards regarding bicompatibility researches that involve osteoblasts populations.

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Mechanical Behaviour of Orthopaedic Cement Loaded with Antibiotics in the Operation Room

Cited by 9 publications

References 14 publications

Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles

Modification of PMMA Cements for Cranioplasty with Bioactive Glass and Copper Doped Tricalcium Phosphate Particles

Progress of antibiotic-loaded bone cement in joint arthroplasty

A Step Forward Standardization of Biocompatibility Testing on Tissue Culture Polystyrene

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