Study of the link between dopamine transporter gene polymorphisms and response to paroxetin and escitalopram in patients with lifelong premature ejaculation

Abstract

We evaluated the role of dopamine (DA) transporter gene polymorphism in lifelong premature ejaculation (LPE) and its role in determining the response to paroxetine and escitalopram. Eighty consecutive patients and controls were recruited. Sixty of them suffered from LPE. They were divided into two equal groups. One group received paroxetine 20 mg daily for 3 months and the other one received ecistalopram 20 mg daily for 3 months. Their wives were instructed to measure the intra-vaginal ejaculation latency time using stopwatch. Five milliliters of blood was withdrawn from patients and controls for PCR analysis. The present study revealed that the mean ages of the patients and controls were 41.42 and 36.4 years, respectively. The majority of the patients were of (10R/10R) genotypes of the DA transporter gene polymorphism, whereas the controls were of (6R/6R) genotypes and this revealed statistically significant result (P-value=0.001). Both paroxitine and escitalopram significantly delayed ejaculation in the responders (P-values=0.001 and 0.001, respectively). The study revealed significant association between such response and DA transporter gene polymorphism (P-values of fold increase and log FI were 0.019 and 0.010, respectively). To the best of our knowledge, this is the first report to demonstrate a highly significant association between such response and DA transporter gene polymorphism in patients with LPE.

Mechanism of Shugan Yidan fang, a Chinese herbal formula, in rat model of premature ejaculation

“…Several studies have shown a relationship between PE and polymorphism of the DAT genes, such as SLC6A3 and DAT1 [ 22 , 23 ]. A study by Eltonsi [ 24 ] reported that gene polymorphism of DAT determined the response of paroxetine and escitalopram to lifelong PE. These results indicated that heredity decrease in DAT may be a risk factor for the development of PE.…”

Possible Pathophysiological Roles of Neurotransmitter Systems in Men With Lifelong Premature Ejaculation: Protocol for a Scoping Review (Preprint)

“…Waldinger further elaborated on this result and thus extended the field of genetic research since 1998 [9]. Thereafter, several studies have examined multiple genes and associated them with the occurrence of LPE [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Although a clear cause of LPE has not yet been revealed, Schapiro [8] reported that patients responded well to sedatives.…”

Effect of a tadalafil 5-mg single daily dose on lifelong premature ejaculation: A single-blinded placebo-controlled study

“…However, there has been increasing evidence in recent years for underlying genetic and neurological mechanisms. The serotonin (5-hydroxytryptamine [5-HT]) 1A or 2 C receptor genes, as well as the dopamine transporter gene, may, for example, contribute to the intravaginal ejaculation latency time (IELT) of lifelong PE, although this remain debatable [ 7 , 8 ].…”