We evaluated the role of dopamine (DA) transporter gene polymorphism in lifelong premature ejaculation (LPE) and its role in determining the response to paroxetine and escitalopram. Eighty consecutive patients and controls were recruited. Sixty of them suffered from LPE. They were divided into two equal groups. One group received paroxetine 20 mg daily for 3 months and the other one received ecistalopram 20 mg daily for 3 months. Their wives were instructed to measure the intra-vaginal ejaculation latency time using stopwatch. Five milliliters of blood was withdrawn from patients and controls for PCR analysis. The present study revealed that the mean ages of the patients and controls were 41.42 and 36.4 years, respectively. The majority of the patients were of (10R/10R) genotypes of the DA transporter gene polymorphism, whereas the controls were of (6R/6R) genotypes and this revealed statistically significant result (P-value=0.001). Both paroxitine and escitalopram significantly delayed ejaculation in the responders (P-values=0.001 and 0.001, respectively). The study revealed significant association between such response and DA transporter gene polymorphism (P-values of fold increase and log FI were 0.019 and 0.010, respectively). To the best of our knowledge, this is the first report to demonstrate a highly significant association between such response and DA transporter gene polymorphism in patients with LPE.

Introduction: several studies demonstrated the potential role of serum leptin in patients with premature ejaculation. Aim: we aimed in this study to evaluate the correlation between body mass index, serum leptin and intra-vaginal ejaculation latency time in patients with lifelong premature ejaculation and healthy controls. Patients and Methods: this study was carried out on 80 consecutive patients and controls. Body mass index was measured in the patients and the controls. Serum leptin was measured in both groups at the end of the study. Additionally, the patients and the controls were asked to measure intra vaginal ejaculation latency time (IELT) by stop watch handled by their wives for 2 successive months. Results: our prospective analysis revealed a highly significant association between body mass index and serum leptin and intra-vaginal ejaculation latency time among the cases (p-value < 0.001, <0.001 respectively). Additionally, body mass index (BMI) did reveal significant association with intra-vaginal ejaculation latency time (p-value=0.014) only, without any association with serum leptin (p-value = 0.391) among the controls. Discussion: the current study demonstrated a statistically significant association between BMI and serum leptin and IELT in the patients with lifelong premature ejaculation. Additionally, the results revealed a statistically significant association between BMI and IELT in the controls without any association with the serum leptin. Conclusion: the current study highlights the role of both body mass index and serum leptin as potential risk factors in patients with lifelong premature ejaculation. Eventually, future studies are required to duplicate this interesting association between body mass index, serum leptin and intra-vaginal ejaculation latency time in patients with lifelong premature ejaculation.

No abstract

The relationship between cytokines and human reproduction has been the subject of a variety of studies because of their involvement in reproductive physiology and gonadal function. Objective: To assess the clinical value of measurement of interleukin-6 (IL-6) in seminal plasma of infertile men and as a marker of male accessory gland infection. Patients and Methods: Ninety men were subjected to this study (75 infertile & 15 fertile). All studied individuals were subjected to; medical history, physical examination, Doppler ultrasonography on scrotum, semen analysis, detection of antisperrn antibodies (ASAbs), serum FSH and LH, measurement of IL-6 concentration in seminal plasma (SP). The studied population were classified into 6 groups; I (fertile), 2 (azoospermia), 3 (immuno-infertile), 4 (varicocele), 5 (oligo-astheno-terato-zoospermia, OAT) and 6 (OAT +infection). Results: Showed that IL-6 was expressed in seminal plasma of all studied groups and its median concentration was 29 Pg/rnl. IL-6 concentration showed a high statistical significant difference between all studied groups (p < 0.001). The highest mean value was recorded in group 6 (76.93 ±13.07) followed by group 3 (52.2 ± 5/09) and then group 4 (42 ± 6.18). No significant difference was detected between IL-6 value and different sperm parameters in studied groups (p > 0.05). However, pH value in group 3 and 6 showed significant difference when compared with that of fertile group (p < 0.0(1). There was no significant difference between serum FSH, LH and IL-6 concentration in seminal plasma (p > 0.05). High IL-6 value was noticed in cases associated with ASAbs. In Conclusion : This study revealed that the IL-6 most probably has a role in male infertility cases which are associated with infection, immuno-infertile cases and with varicocele. Moreover, the simultaneous determination of IL-6 in SP may provide a sensitive and useful marker of silent infection I inflammation of the male genital tract.

No abstract