Warts are common benign proliferations of the skin that are caused by human papillomavirus (HPV) and can be classified into different types (flat, filiform, plantar, and genital). 1 A number of immunotherapeutic agents had been successfully used in treating warts including imiquimod, bacillus Calmette-Guérin (BCG) vaccine, HPV vaccine, interferon, systemic zinc, cimetidine, and levamisole. 2 It is worth mentioning that despite resistance of warts to treatment especially in adults and immune-suppressed patients, success of treatment usually depends on the host's immune status, virus type, duration, and number of lesions. 3 Recently, studies shed light on the potential role of vitamin D in the regulation of both adaptive and innate immunity. 4 Additionally, it plays a key role in antimicrobial innate responses by characterizing an autocrine vitamin D pathway in human monocytes/ macrophages after

Background Pumpkin (Cucurbita pepo L.) is an annual climber plant, and its seeds have considerable amount of oil with nutritional and medicinal importance. Aim The present study aimed to investigate the clinical efficacy of pumpkin seed oil (PSO) in the treatment of female pattern hair loss (FPHL) and compare its effects with minoxidil 5% foam. Methods Patients with FPHL were randomly assigned to pumpkin seed oil (n = 30; group A) or minoxidil 5% foam (n = 30; group B) for a period of 3 months. Patients were evaluated clinically and dermoscopically at baseline, at one and half months, and at the end of the 3‐month study. Results Among group A (pumpkin seed oil) candidates, a significant decrease was observed in hair shaft diversity before and after treatment (30.5 ± 6.2%, 24.0 ± 4.02, P < .001, respectively) as well as in the vellus hairs (22.5 ± 4.9, 15.8 ± 2.2, P < .001, respectively). Upright regrowing hairs significantly increased from (0.13 ± 0.5) before treatment to (0.9 ± 1.0) after treatment (P < .001). In group B (minoxidil applying) candidates, a significant decrease was observed in hair shaft diversity before and after treatment (31.5 ± 6.3%, 21.3 ± 2.2, P < .001, respectively) as well as in the vellus hairs (24.7 ± 6.4, 19.5 ± 5.4, P = .02, respectively). Conclusion Findings of the present trial provide evidence of a promising potential role of PSO in treating FPHL.

Major epidemic outbreaks create an increased demand for healthcare workers (HCWs) and pose increased health risk to them as well. 1 It is worth mentioning that during initial phase of COVID-19 outbreak, and 29% of all hospitalized patients were HCWs. 2 The constant increasing of infected cases, newer waves of the virus, increase in death tolls among physicians and uncertainty and scarcity of vaccination in many parts of the world to date while devising this study, extensive media pressure and plethora of rumors had all contributed to increased mental burden and anxiety of physicians and medical teams. 3 Such mentally exhaustive situations may negatively impact mental and emotional health of physicians and healthcare workers as such. 4 The number of Egyptian physicians infected by corona virus has increased alarmingly, and their death toll had reached 327 at the time of writing this study while only 1327 had received vaccination. 5

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