Study of the paraoxonase and platelet-activating factor acetylhydrolase activities with aging

Milochevitch, Christelle; Khalil, Abdelouahed

doi:10.1054/plef.2001.0320

Cited by 43 publications

(24 citation statements)

References 34 publications

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“…In contrast to our results, a loss of PON1 activity with aging has been described in humans (33)(34)(35). Although the influence of genotype on human serum PON1 activity cannot be ruled out, interspecies differences could explain the different antiaging mechanisms involving PON1 that act in both rats and humans.…”

Section: Discussioncontrasting

confidence: 99%

The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats

Thomàs-Moyà

Gianotti

Proenza

et al. 2006

Journal of Lipid Research

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Caloric restriction (CR) has been shown to attenuate age-related oxidative damage and to improve major atherosclerotic risk factors. Paraoxonase 1 (PON1), an enzyme specifically associated with HDL containing apolipoproteins A-I and J, has been reported to prevent the proatherosclerotic effects of oxidized LDL. The aim of this study was to evaluate whether modulation of PON1 activity is part of the underlying CR mechanisms that attenuate the ageassociated negative effects. Experimental groups were 1 year old rats of both genders subjected to 40% CR for 1 year and two ad libitum-fed groups, also including rats of both genders, euthanized at 6 months or 2 years. Aging impaired the serum lipid profile and increased lipid peroxidation, PON1 activities, and the content of both PON1 and apolipoprotein J in HDL, which suggests an HDL subfraction redistribution to protect LDL more effectively from oxidation. The CRassociated improved lipid profile and the decreased lipid peroxide levels would lead to the decreased arylesterase activity seen in old CR animals, suggesting that PON1 modulation is not an integral part of the main antioxidant mechanisms of CR but rather that CR would determine a more youthful and less oxidative situation in which the protection of LDL would be less necessary.-Thomàs-Moyà, E., M. Gianotti, A. M. Proenza, and I. Lladó. The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats.

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Section: Discussioncontrasting

confidence: 99%

The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats

Thomàs-Moyà

Gianotti

Proenza

et al. 2006

Journal of Lipid Research

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show abstract

“…This decline, they suggested, is a consequence of oxidative stress produced during aging. Other investigators have also identified aging as an important reason for decreased PON1 activity [42,43]. Another contributing factor could be the interaction of glucose with proteins leading to the formation of advanced glycation end products (AGEs).…”

Section: Discussionmentioning

confidence: 99%

Assessment of paraoxonase activity and lipid peroxidation levels in diabetic and senile subjects suffering from cataract

Hashim

Zarina

2007

Clinical Biochemistry

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“…PAF-AH activity was measured using 1-palmitoyl-2-[(7-nitrobenzoxadiazoyl) amino] caproyl phosphatidylcholine (C6NBD PC) as the substrate, as described previously (Milochevitch and Khalil, 2001). The amount of fluorescent substrate hydrolyzed was calculated using a standard curve generated with C6NBD PC dissolved in methanol.…”

Section: Measurement Of Paf-ah Activitymentioning

confidence: 99%

The anti-inflammatory effect of paraoxonase 1 against oxidized lipids depends on its association with high density lipoproteins

et al. 2012

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Study of the paraoxonase and platelet-activating factor acetylhydrolase activities with aging

Cited by 43 publications

References 34 publications

The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats

The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats

Assessment of paraoxonase activity and lipid peroxidation levels in diabetic and senile subjects suffering from cataract

The anti-inflammatory effect of paraoxonase 1 against oxidized lipids depends on its association with high density lipoproteins

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