The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats

Thomàs-Moyà, Elena; Gianotti, Magdalena; Proenza, Ana M.; Lladó, Isabel

doi:10.1194/jlr.m600215-jlr200

Cited by 10 publications

(10 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a whole, these results point to a greater oxidative status in the organism that, in part, would result from impaired antioxidant capacity. Although the antioxidant role of PON1 has recently been called into question (43), the present results and others previously described in different physiological situations characterized by changes in the oxidative status (18,19,20,44), suggest that this enzyme would be involved in the response to oxidative stress.…”

Section: Discussionsupporting

confidence: 51%

“…These gender differences in both PON1 activity and stability have been previously reported in younger rats (18). However, the inversion of gender differences in serum PON1 activity observed with aging (20) is not yet obvious at 18 months of age.…”

Section: Discussionmentioning

confidence: 99%

“…Serum PON1 activity can be modulated by both dietary factors and oxidative stress (16), being decreased in obesity and inactivated by increased oxidative stress (10,17). Furthermore, in previous studies we have evidenced that gender influences the PON1 response to alterations in the oxidative environment in both dietary and physiological situations (18)(19)(20).…”

mentioning

confidence: 85%

See 2 more Smart Citations

Gender Related Differences in Paraoxonase 1 Response to High‐fat Diet‐induced Oxidative Stress

Thomàs-Moyà

Gómez-Pérez

Fiol

et al. 2008

Obesity

Self Cite

View full text Add to dashboard Cite

Objective: To evaluate the influence of the pro-oxidant and proinflammatory state related to dietary obesity on serum paraoxonase 1 (PON1) activity in male and female rats. Methods and Procedures: Adult Wistar rats of both genders were fed on a high-fat diet to induce weight gain or standard diet for 14 weeks. Body weight was assessed weekly and food intake fortnightly throughout the dietary treatment. Biometrical parameters and serum lipid profile, glucose, insulin, and adipokine levels were measured. To assess the effect of dietary obesity on oxidative stress, levels of liver and serum thiobarbituric acid reactive substances, liver protein carbonyl groups, liver antioxidant enzymes activities, and serum PON1 activities were measured. Results: High-fat diet feeding induced a significant body weight gain in both male and female rats, as well as a reduction of liver antioxidant protection. High-fat diet increased serum lipid peroxides in male rats and reduced serum PON1 activities and serum apolipoprotein A-I (apoA-I) levels in females, although did not alter serum PON1 or apolipoprotein J (apoJ) levels. Discussion: Our results reveal a gender dimorphism in the high-fat diet-induced reduction of serum PON1 activity, which is likely to be related to the greater obese and proinflammatory state achieved in female rats. We suggest that the enhanced oxidative stress caused by dietary increased body weight, on leading to high-density lipoprotein (HDL), apoA-I or PON1 oxidation could entail the destabilization of the PON1 association to HDL or a direct inactivation of PON1 enzymatic activity, thus accounting for the decreased serum PON1 activities observed in female rats.

show abstract

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 85%

See 1 more Smart Citation

Gender Related Differences in Paraoxonase 1 Response to High‐fat Diet‐induced Oxidative Stress

Thomàs-Moyà

Gómez-Pérez

Fiol

et al. 2008

Obesity

Self Cite

View full text Add to dashboard Cite

show abstract

“…As we previously reported, the decreased serum PON1 activity induced by caloric restriction was a direct consequence of a lower number of PON1 molecules in the blood as a result of the reduced HDL content of apoA-I and apoJ, leading to a loss of stability in the PON1-HDL complexes and/or to lower levels of the HDL subfraction to which PON1 associates [39,40]. However, the mechanisms involved in the changes in PON1 activity during fasting are different from those operating during caloric restriction and cannot be attributed either to changes in apoA-I, apoJ or PON1 serum levels.…”

Section: Kdamentioning

confidence: 69%

Time-dependent modulation of rat serum paraoxonase 1 activity by fasting

Thomàs-Moyà

Nadal-Casellas

Gianotti

et al. 2006

Pflugers Arch - Eur J Physiol

Self Cite

View full text Add to dashboard Cite

High-density lipoprotein-associated paraoxonase 1 (PON1) protects the endothelium from the pro-oxidant activity of oxidised low-density lipoprotein. Whereas fasting has been related to increased oxidative stress, intermittent fasting and caloric restriction are associated to increased resistance to oxidative injury. Taking into consideration that serum PON1 activity is modulated by a restriction of caloric intake and because there is no evidence regarding PON1 response to total food deprivation, we investigated whether PON1 activity is involved in the response aimed to counteract the greater oxidative stress associated to fasting and whether serum PON1 activity is altered by the length of food deprivation. Male Wistar rats were randomly divided into five groups: fed and 6-, 12-, 24- or 48-h fasted rats. Serum PON1 activity increases within the first hours of fasting, representing a prompt adaptation designed to attenuate blood lipid peroxidation that cannot be sustained when fasting is prolonged. This PON1 response to early fasting could be part of the mechanisms triggered by periodically repeated short periods of food deprivation - intermittent fasting - which result in increased resistance to stress by stimulating antioxidant defences.

show abstract

“…Paraoxonase and ARE activities have different patterns in response to DR. Long‐term DR decreased testicular ARE activities significantly in both temperatures ( P < 0.05), while it did not change PON activity significantly in this study. This discrepancy between PON and ARE may be due to differences in the specific regulation of both enzymes (Thomas‐Moya et al ., ). It has been reported that the effect of DR depends on many variables such as age and duration and degree of restriction (Gredilla et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Effect of dietary restriction on sperm characteristic and oxidative status on testicular tissue in young rats exposed to long-term heat stress

et al. 2014

View full text Add to dashboard Cite

This study was conducted to evaluate the effects of dietary restriction on oxidative status and sperm parameters in rats exposed to long-term heat stress. Forty healthy Sprague-Dawley rats, aged 2.5 month, were divided into four groups of 10 with respect to feeding and temperature regimen (room temperature (22 °C)-ad libitum, room temperature-dietary restriction (40%), high temperature (38 °C)-ad libitum, high temperature-dietary restriction). At the end of the 9th week, some oxidants (lipid hydroperoxide, total oxidant status, oxidative stress index) and antioxidants (total antioxidant status, sulfhydryl groups, ceruloplasmin, paraoxonase and arylesterase activities) were measured in the testis tissue. The concentration, motility, volume, abnormal sperm count, acrosome and membrane integrity of epididymal spermatozoon and intratesticular testosterone levels were evaluated. High temperature did not change oxidative and antioxidative parameters except for sulfhydryl groups and ceruloplasmin, yet it impaired all sperm values. Neither sperm values nor oxidative status apart from sulfhydryl groups, ceruloplasmin and arylesterase was affected by dietary restriction in the testis tissue. These results suggest that long-term heat stress does not have a significant effect on testicular oxidative status, while the spermatozoa are sensitive to heat stress in young rats. Dietary restriction failed to improve the sperm quality and oxidative status except some individual antioxidant parameters; conversely, it decreased intratesticular testosterone level in the young rats exposed to long-term heat stress.

show abstract

The age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats

Cited by 10 publications

References 41 publications

Gender Related Differences in Paraoxonase 1 Response to High‐fat Diet‐induced Oxidative Stress

Gender Related Differences in Paraoxonase 1 Response to High‐fat Diet‐induced Oxidative Stress

Time-dependent modulation of rat serum paraoxonase 1 activity by fasting

Effect of dietary restriction on sperm characteristic and oxidative status on testicular tissue in young rats exposed to long-term heat stress

Contact Info

Product

Resources

About