Study of the phase behavior of polyethylene glycol 6000–itraconazole solid dispersions using DSC

A resorbable antibiotic eluting bone void filler for periprosthetic joint infection prevention

“…DSC data (not shown) demonstrated phase transitions for the materials used in this work to be similar to those reported in literature—slight variances attributable to differences in molecular weight . Peak melting temperature ranges for PCL and PEG were observed to be 65.8–69.0°C and 62.0–63.6°C, respectively.…”

Heat induced evaporative antisolvent nanoprecipitation (HIEAN) of itraconazole

“…The thermograms of the NPs were similar to that of the glassy ITR as described by Wang et al (2004). The three NP samples exhibited a glass transition (Tg) event at approximately 60 °C, two endothermic transitions at 74 (T LC1 ) and 90 °C (T LC2 ) due to the formation of a chiral nematic 340 mesophase (Six et al 2001) and finally melting at ~168 °C.…”

A Solid-State Approach to Enable Early Development Compounds: Selection and Animsal Bioavailability Studies of an Itraconazole Amorphous Solid Dispersion

“…Amorphous solid dispersions of ITZ have also been studied using a number of polymers as stabilizing agents including polyethylene glycol27 (PEG 6000,28 PEG 2000029), polyvinylpyrrolidone (PVP),30 hydroxy propyl methyl cellulose (HPMC),31 hydroxyl propyl cellulose (HPC),30 ethylcellulose (EC 20 cps),32 Eudragit® E100,33, 34 polyvinylacetal diethylaminoacetate (AEA®),29 polyoxyethylene–polyoxypropylene copolymers (Poloxamer® 188),29 Inutec SP1,35 polyvinylpyrrolidone vinyl acetate (PVPVA64),36 Kollicoat IR®,37 and hydroxypropylmethylcellulose phthalate (HP55) 38. Mixtures of polymers have also been evaluated such as Eudragit® E‐100/polyvinyl PVPVA64,39, 40 hydroxypropyl‐ β ‐cyclodextrin (HP‐ β ‐CD)/HPMC,41 d‐alpha‐tocopheryl polyethylene glycol (TPGS 1000)/PVPVA64,42 PEG 6000/HPMC 2910 E5,43, 44 and PVPVA64/Myrj 52 45.…”