Study of the physicochemical and biological properties of the new promising Ti–20Nb–13Ta–5Zr alloy for biomedical applications

Konushkin, S. V.; Sergiyenko, K. V.; Nasakina, E. O.; Leontyev, V. G.; Kuznetsova, O. G.; Титов, Д. Д.; Tsareva, A. M.; Dormidontov, N. A.; Kirsankin, A. A.; Канныкин, С. В.; Sevostyanov, M. A.; Kritskaya, Kristina A.; Berezhnov, Alexey V.; Laryushkin, Denis P.; Куликов, А. В.; Belosludtsev, Konstantin N.; Antipov, S.S.; Volkov, Mikhail Yu; Козлов, В. А.; Rebezov, Мaksim; Shikirin, Alexey V.; Baimler, Ilya V.; Simakin, Alexander V.; Gudkov, Sergey V.

doi:10.1016/j.matchemphys.2020.123557

Cited by 24 publications

(8 citation statements)

References 63 publications

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“…The mitotic index of cells in the logarithmic growth phase (3 days after seeding) was used to analyze cell proliferation. The number of cells in a state of mitosis was determined using fluorescence microscopy using in-vitro staining with the Hoechst 33342 fluorescent dye (Sigma, Saint-Louis, MO, USA) [ 31 ]. The density of the culture was assessed using the approaches developed earlier [ 32 ].…”

Section: Methodsmentioning

confidence: 99%

Additive Production of a Material Based on an Acrylic Polymer with a Nanoscale Layer of Zno Nanorods Deposited Using a Direct Current Magnetron Discharge: Morphology, Photoconversion Properties, and Biosafety

et al. 2021

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On the basis of a direct current magnetron, a technology has been developed for producing nanoscale-oriented nanorods from zinc oxide on an acrylic polymer. The technology makes it possible to achieve different filling of the surface with zinc oxide nanorods. The nanorods is partially fused into the polymer; the cross section of the nanorods is rather close to an elongated ellipse. It is shown that, with intense abrasion, no delamination of the nanorods from the acrylic polymer is observed. The zinc oxide nanorods abrades together with the acrylic polymer. Zinc oxide nanorods luminesces with the wavelength most preferable for the process of photosynthesis in higher plants. It was shown that plants grown under the obtained material grow faster and gain biomass faster than the control group. In addition, it was found that on surfaces containing zinc oxide nanorods, a more intense formation of such reactive oxygen species as hydrogen peroxide and hydroxyl radical is observed. Intensive formation of long-lived, active forms of the protein is observed on the zinc oxide coating. The formation of 8-oxoguanine in DNA in vitro on a zinc oxide coating was shown using ELISA method. It was found that the multiplication of microorganisms on the developed material is significantly hampered. At the same time, eukaryotic cells of animals grow and develop without hindrance. Thus, the material we have obtained can be used in photonics (photoconversion material for greenhouses, housings for LEDs), and it is also an affordable and non-toxic nanomaterial for creating antibacterial coatings.

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Section: Methodsmentioning

confidence: 99%

Additive Production of a Material Based on an Acrylic Polymer with a Nanoscale Layer of Zno Nanorods Deposited Using a Direct Current Magnetron Discharge: Morphology, Photoconversion Properties, and Biosafety

et al. 2021

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“…), BS-based materials can have different mechanical properties. They can be in both solid and liquid state of aggregation, and also have a viscous, rubbery, or glassy consistency [37]. Highly elastic behavior is realized due to stretching of siloxane fragments, and viscous due to the fact that these formed layers can freely move relative to each other.…”

Section: Physicochemical Characteristics Of Materials and Compositementioning

confidence: 99%

New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

et al. 2021

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The present study a comprehensive analysis of the antibacterial properties of a composite material based on borosiloxane and zinc oxide nanoparticles (ZnO NPs). The effect of the polymer matrix and ZnO NPs on the generation of reactive oxygen species, hydroxyl radicals, and long-lived oxidized forms of biomolecules has been studied. All variants of the composites significantly inhibited the division of E. coli bacteria and caused them to detach from the substrate. It was revealed that the surfaces of a composite material based on borosiloxane and ZnO NPs do not inhibit the growth and division of mammalians cells. It is shown in the work that the positive effect of the incorporation of ZnO NPs into borosiloxane can reach 100% or more, provided that the viscoelastic properties of borosiloxane with nanoparticles are retained.

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“…In low elastic modulus Ti-Nb-Sn alloys, the Sn content does not exceed 4 wt./wt.% [ 64 , 65 ]. In contrast, the Zr content of low elastic modulus Ti-Nb-Ta-Zr alloys (55–60 GPa) is in the range of 4.5–7.0 wt./wt.% [ 66 , 67 , 68 ], an example, Ti-29Nb-13Ta-4.6Zr ([Mo]eq = 10.7) [ 3 , 69 , 70 ]. A shortcoming of this alloy is its relatively high cost due to the high content of Ta.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Characterization of a Novel Biocompatible Alloy, Ti-Nb-Zr-Ta-Sn

Khrunyk

Ehnert

Гриб

et al. 2021

IJMS

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Many current-generation biomedical implants are fabricated from the Ti-6Al-4V alloy because it has many attractive properties, such as low density and biocompatibility. However, the elastic modulus of this alloy is much larger than that of the surrounding bone, leading to bone resorption and, eventually, implant failure. In the present study, we synthesized and performed a detailed analysis of a novel low elastic modulus Ti-based alloy (Ti-28Nb-5Zr-2Ta-2Sn (TNZTS alloy)) using a variety of methods, including scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and tensile test. Additionally, the in vitro biocompatibility of the TNZTS alloy was evaluated using SCP-1, SaOs-2, and THP-1 cell lines and primary human osteoblasts. Compared to Ti-6Al-4V, the elastic modulus of TNZTS alloy was significantly lower, while measures of its in vitro biocompatibility are comparable. O2 plasma treatment of the surface of the alloy significantly increased its hydrophilicity and, hence, its in vitro biocompatibility. TNZTS alloy specimens did not induce the release of cytokines by macrophages, indicating that such scaffolds would not trigger inflammatory responses. The present results suggest that the TNZTS alloy may have potential as an alternative to Ti-6Al-4V.

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Study of the physicochemical and biological properties of the new promising Ti–20Nb–13Ta–5Zr alloy for biomedical applications

Cited by 24 publications

References 63 publications

Additive Production of a Material Based on an Acrylic Polymer with a Nanoscale Layer of Zno Nanorods Deposited Using a Direct Current Magnetron Discharge: Morphology, Photoconversion Properties, and Biosafety

Additive Production of a Material Based on an Acrylic Polymer with a Nanoscale Layer of Zno Nanorods Deposited Using a Direct Current Magnetron Discharge: Morphology, Photoconversion Properties, and Biosafety

New Organosilicon Composite Based on Borosiloxane and Zinc Oxide Nanoparticles Inhibits Bacterial Growth, but Does Not Have a Toxic Effect on the Development of Animal Eukaryotic Cells

Synthesis and Characterization of a Novel Biocompatible Alloy, Ti-Nb-Zr-Ta-Sn

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