Study of the profile of the neurotrophin BDNF in new leprosy cases before, during and after multidrug therapy

Costa, Rosane Dias; Mendonça, Vanessa Amaral; Penido, Rachel Adriana; Lyon, Sandra; Costa, Ana Maria Duarte Dias; Costa, Marina Dias; Terra, Fábio de Souza; Bretas, Thales Lage Bicalho; Antunes, Carlos Maurício de Figueiredo; Teixeira, Antônio Lúcio

doi:10.1590/s0004-282x2011000100019

Cited by 6 publications

(8 citation statements)

References 24 publications

(22 reference statements)

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“…As regards the operational classification and gender, a greater number of multibacillary cases were found in men, which runs in line with findings from Costa, 20 Barbosa et al, 21 and Moschioni. 22 The multibacillary form is a signal that the disease received a late diagnosis, thus favoring the maintenance of the transmission chain, given that it is considered to be the main means of disease transmission.…”

Section: Discussionsupporting

confidence: 88%

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Limitation of activity and restriction of social participation in relation to age range, gender, and education in people with leprosy

Reis

Castro

Fernandes

2017

An. Bras. Dermatol.

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BackgroundIn Brazil, 38,000 new cases of leprosy are discovered each year, making it a public health problem.ObjectiveTo identify whether or not there is an association between activity limitations and the restriction of social participation with some demographic data (age range, gender, and education) of the patients in a Basic Health Unit (BHU), diagnosed with leprosy.MethodsThe SALSA scale was used to assess activity limitations, whereas the Participation scale was used to assess the restriction of social participation.ResultsThe assessments were conducted with 31 BHU patients diagnosed with leprosy. Males were the most affected by leprosy, the multibacillary was the most prevalent, and education proved to be an important factor when related to the disease injuries among the evaluated individuals. Regarding activity limitations and the restriction of social participation, the percentage of individuals without limitations and without restrictions was greater in both scales.Study limitationsThe main limitation is the small study sample.ConclusionIt can be concluded that, for the studied sample, no association was observed between the activity limitations, evaluated by the Salsa scale, nor the restriction of social participation, evaluated by the Participation Scale, with the analyzed demographic data.

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Section: Discussionsupporting

confidence: 88%

“…19 Hence, biological and economic factors, and especially differences in the sociocultural behavior between the genders, may well be related to the greater detection of cases in the male population. 20 …”

Section: Discussionmentioning

confidence: 99%

Limitation of activity and restriction of social participation in relation to age range, gender, and education in people with leprosy

Reis

Castro

Fernandes

2017

An. Bras. Dermatol.

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“…In spite of antibodies against NGF have also been implicated as indicators of leprosy neuritic status 27 , serological data in our study did not demonstrate any differences between leprosy and control serum samples concerning circulating neurotrophins, suggesting that it is not a representative method to evaluate neural damage in non-reactional leprosy. In accordance, Costa et al 28 did not find differences in BDNF serum levels in healthy control and leprosy patients before, during and after multidrug therapy. We also investigated alterations in clinical parameters, such as loss of protective sensitivity, and its possible correlation with tissue expression of neurotrophins.…”

Section: Discussionsupporting

confidence: 77%

Leprosy patients: neurotrophic factors and axonal markers in skin lesions

Michellin

Barreto

Marciano

et al. 2012

Arq. Neuro-Psiquiatr.

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The main principles of leprosy control consist of early detection of new cases, proper treatment by multidrug therapy (MDT), prevention of disabilities and rehabilitation 1 . In spite of worldwide efforts, endemic countries still have leprosy control as an unreached goal. The prevention and recovery of peripheral neuropathy are among the hardest challenges of leprosy. In Brazil, approximately 5.9% of new cases of leprosy present grade II of disability at the moment of first diagnosis 1 . Unfortunately, the established neural impairment tends to persist as lifelong sequelae in these patients 2 .Mycobacterium leprae (M. leprae) has tropism for the peripheral nervous system, where it infects Schwann cells and eventually endothelium Key words: peripheral nerves, leprosy. RESUMONeurotrofinas são fatores de crescimento com papel fundamental na fisiopatologia neural. Esses mediadores modulam funcionalmente fibras nociceptivas. Mudanças em sua expressão têm sido relacionadas à perda precoce da nocicepção na hanseníase. Este estudo investigou a expressão de NGF, BDNF e NT3 em nervos dérmicos de pacientes hansenianos. A caracterização de fibras nervosas não mielinizadas foi feita por p75 NTR e marcadores axonais NF-L e PGP 9.5. Os parâmetros clínicos de dano neural foram avaliados por monofilamentos Semmes-Wenstein. Nossos achados demonstram diminuição de NGF nos pacientes dimorfos em comparação aos controles. Resultados similares foram observados para PGP 9.5 (dimorfos: p<0,001; virchowianos: p<0,05) e NF-L (virchowianos: p<0.05), sugerindo degeneração avançada das terminações nervosas na hanseníase multibacilar. Foi observada correlação positiva entre p75 NTR e PGP 9.5, indicando associação entre células de Schwann e axônios em fibras nervosas não mielinizadas. Os resultados indicam que o desequilíbrio na expressão das neurotrofinas pode participar do dano neural periférico.Palavras-Chave: nervos periféricos, hanseníase.

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“…(12) One study demonstrated that BDNF levels tend to be lower in leprosy patients than in healthy individuals, which might reflect how MLinfection triggers the loss of neurotrophic stimulus by BDNF downregulation. (13) The therapeutic implications in neurotrophins regulation on the myelination program of the peripheral nervous system may be extended to demyelinating peripheral neuropathies, including leprosy, and nerve injury. (14) Given the significant role of neurotrophins on neural homeostasis and recovery after injury, we aimed to investigate the effect of ML on neurotrophins expression in human SC and mice sciatic nerves to better understand their role in leprosy neuropathy, and aiming to contribute to future therapeutic approaches.…”

mentioning

confidence: 99%

“… 12 One study demonstrated that BDNF levels tend to be lower in leprosy patients than in healthy individuals, which might reflect how ML-infection triggers the loss of neurotrophic stimulus by BDNF downregulation. 13 …”

mentioning

confidence: 99%

Effect of Mycobacterium leprae on neurotrophins expression in human Schwann cells and mouse sciatic nerves

Costa

Amôr

Michellin

et al. 2020

Mem. Inst. Oswaldo Cruz

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BACKGROUND Although Mycobacterium leprae (ML) is well characterised as the causative agent of leprosy, the pathophysiological mechanisms underlying peripheral nerve damage still need further understanding. In vitro and in vivo studies have yielded insights into molecular mechanisms of ML interaction with Schwann cells (SC), indicating the regulation of genes and proteins crucial to neural plasticity. OBJECTIVES We aimed to investigate the effect of ML on neurotrophins expression in human SC (hSC) and mice sciatic nerves to better understand their role in leprosy neuropathy, and aiming to contribute to future therapeutic approaches. METHODS We evaluated mRNA and protein expression of BDNF, NGF, NT-3, NT-4 in hSC from amputation nerve fragments, as well as in athymic nude mice, infected by ML for eight months. FINDINGS and MAIN CONCLUSIONS Our in vitro results showed a trend to decline in NGF and BDNF mRNA in ML-treated hSC, compared to controls. The immunodetection of BDNF and NT-4 was significantly downregulated in ML-treated hSC. Conversely, ML-infected mice demonstrated upregulation of NT-3, compared to non-infected animals. Our findings indicate that ML may be involved in neurotrophins regulation, suggesting that a pathogen-related imbalance of these growth factors may have a role in the neural impairment of leprosy.

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Study of the profile of the neurotrophin BDNF in new leprosy cases before, during and after multidrug therapy

Cited by 6 publications

References 24 publications

Limitation of activity and restriction of social participation in relation to age range, gender, and education in people with leprosy

Limitation of activity and restriction of social participation in relation to age range, gender, and education in people with leprosy

Leprosy patients: neurotrophic factors and axonal markers in skin lesions

Effect of Mycobacterium leprae on neurotrophins expression in human Schwann cells and mouse sciatic nerves

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