Study of the Protective Effects of Quince (Cydonia Oblonga) Leaf Extract on Fertility Alterations and Gonadal Dysfunction Induced by Monosodium Glutamate in Adult Male Wistar Rats

Abstract

Background and Aims: Starting from the cytotoxic effects of monosodium glutamate (MSG), the aim of this study was to evaluate the protective effects of quince leaf extract as natural antioxidant on the reproductive dysfunction induced by monosodium glutamate in rats. Material and methods: Monosodium glutamate was administrated with a dose of 30 and 60 mg/kg and quince leaf extract was administrated with a dose of 500 mg/kg. At the end of study, body and testicular weight measurement, hormonal and epididymal sperm analysis were performed. Results: Follicle stimulating hormone (FSH) and testosterone levels were reduced after administration of monosodium glutamate. The levels of luteinizing hormone (LH) exhibited no significant changes. Treatment with quince leaf extract led to improvement in follicle stimulating hormone and testosterone levels. Epididymal sperm population was reduced after administration of monosodium glutamate and treatment with quince leaf extract. The increased sperm motility rate induced by monosodium glutamate was reduced after treatment with quince leaf extract. Administration of monosodium glutamate led to more body weight gain in comparison to combined administration monosodium glutamate and quince leaf extract. Conclusions: The quince leaf extract can be effective in reduction of functional alterations of reproductive system induced by monosodium glutamate.

Study of the Long-Term and Dose Dependent Effects of Methylphenidate and Monosodium Glutamate on the Hormonal Alterations of the Pituitary-Testicular Axis and Sperm Analysis in Adolescence Rats

“…The administration of monosodium glutamate leads to increase of body weight (Diniz et al, 2005). According to our previous study, the higher dose of MSG led to more weight gain in comparison to lower doses of monosodium glutamate (Kianifard et al, 2015). The results of the present study are in consistent with previously reported results.…”

“…The weight of testes depends on the mass of differentiated spermatogenic cells (Katoh et al, 2002). The results from this study confirms our previous studies (Kianifard et al, 2013;Kianifard et al, 2015) about the effects of methylphenidate and monosodium glutamate on testicular weight loss especially when these agents both taken together. Previous studies have shown that, the MPH can alter the brain-pituitary-testicular axis (Adriani et al, 2006).…”

Monosodium Glutamate (MSG)-Induced Male Reproductive Dysfunction: A Mini Review

“…HPA disruption may reduce levels of sex hormones, including testosterone, follicle-stimulating hormone, and luteinizing hormone. This ultimately leads to alterations in sperm quality [21]. Spermatogenesis is totally dependent on the sex hormones and androgen-dependent organs of the reproductive system, which include the prostate gland, epididymis and seminal vesicles.…”

“…Other studies, however, observed improved testicular histopathology after the administration of selenium, vitamin E, and curcumin, respectively [7,22]. Treatments such as graviola extract, vitamin C, vitamin E, camel milk, propolis, quince extract, and curcumin have proven to provide protective effects against MSG-induced histomorphological testicular toxicities [17][18][19][20][21][22].…”

“…Glutamate receptors are found in different organs and tissues, including the endocrine glands, hypothalamus, thymus, ovaries, liver, kidney, and testis. The testis has been found to exhibit morphological alterations subsequent to MSG treatment due to mal-expression of glutamate receptor in the testis [7,10,21].…”