Study of the pseudo-ternary aqueous two-phase systems of deep eutectic solvent (choline chloride:sugars) + K2HPO4 + water

Farias, Fabiane Oliveira; Sosa, Filipe H. B.; Igarashi‐Mafra, Luciana; Coutinho, João A. P.; Mafra, Marcos R.

doi:10.1016/j.fluid.2017.05.018

Cited by 78 publications

(66 citation statements)

References 41 publications

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“…Origin version 8.0 and Design-Expert 7.1.6 were used to analyse the data, which are expressed as the mean ± SD. were:ChCl-UChCl-GluChCl-GChCl-EG.ChCl-U has better phase forming ability in ATPS than others, which was consistent with results reported in the literature (Farias et al, 2017). This phenomenon may have occurred because water is one of the dominant factors affecting DES integrity,which is destroyed in DES-ATPS by breaking the hydrogen bonds within the HBD:HBA complex (Passos et al, 2016).The by ChCl-Glu/K2HPO4-ATPS was proposed in a follow-up study.…”

Section: Discussionsupporting

confidence: 91%

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Deep eutectic solvents aqueous two-phase system based ultrasonically assisted extraction of ursolic acid (UA) from Cynomorium songaricum Rupr.

Zhang

2017

Preprint

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Deep eutectic solvents (DESs) are new green solvents that have attracted the attention of the scientific community mainly due to their unique properties and special characteristics, which are different from those of traditional solvents.A method based on ultrasonically assisted deep eutectic solvent aqueous two-phase systems( UAE-DES-ATPS) was developed for extracting ursolic acid (UA) from Cynomorium songaricum Rupr. Four different types of choline chloride-based DESs were prepared.Choline chloride-glucose (ChCl-Glu) exhibited good selective extraction ability. An optimum DES-ATPS of 36% (w/w) ChCl-Glu and 25% (w/w) K2HPO4 was considered to be a satisfactory system for extracting UA. Response surface methodology (RSM) method was used to optimize the extraction of UA using UAE-DES-ATPS. The optimum ultrasound-assisted conditions were as follows: solvent to solid ratio of 15:1 (g/g), ultrasound power of 470 W, and extraction time of 54 min. Compared with the conventional UAE method, the yields were basically the same, but the presented method had higher purity. The structure of UA did not change between pure UA and UA in the upper phase by UV–vis and FT-IR. This approach using ChCl-based DES-ATPS as a novel extraction system and ultrasound as a source of energy provided better choice for the separation of active components from other natural products.

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Section: Discussionsupporting

confidence: 91%

“…The stability of DESs in ATPS should be considered. According to Farias et al(2017)and Passos et al(2016), ChCl played a major role in controlling the construction of ATPS, while the HBD had only a small effect. The hydrogen bonds of the DES were destroyed in the prepared ATPS.…”

Section: Discussionmentioning

confidence: 99%

Deep eutectic solvents aqueous two-phase system based ultrasonically assisted extraction of ursolic acid (UA) from Cynomorium songaricum Rupr.

Zhang

2017

Preprint

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“…Several compounds have been studied as substitute of the conventional compounds in ABS, such as ionic-liquids, organic solvents and deep eutectic solvents [4][5][6][7][8][9][10][11][12][13]. Deep eutectic solvents (DES) are a kind of green solvents formed by the association of a hydrogen bond acceptor (HBA) and a hydrogen bond donor (HBD) [9].…”

Section: Introductionmentioning

confidence: 99%

“…Several authors studied the DES-based ABS with the main purpose of extract biomolecules [6,[10][11][12][13]. Passos et al [7] and Farias et al [8] evaluated the DES stability in ATPS and both works proved that the DES complex (between the HBA and HBD) are disrupted due to the high-water content present at the ATPSs, and consequently these systems are actually quaternary systems. Farias et al [8] reinforce the necessity to quantify each of the four compounds to characterize the tie-lines composition in this type of ATPS.…”

Section: Introductionmentioning

confidence: 99%

“…Passos et al [7] and Farias et al [8] evaluated the DES stability in ATPS and both works proved that the DES complex (between the HBA and HBD) are disrupted due to the high-water content present at the ATPSs, and consequently these systems are actually quaternary systems. Farias et al [8] reinforce the necessity to quantify each of the four compounds to characterize the tie-lines composition in this type of ATPS. In the same way, the thermodynamic modeling needs to be done considering all the four compounds e not a pseudo-ternary system.…”

Section: Introductionmentioning

confidence: 99%

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Thermodynamic Modeling of Pseudoternary Aqueous Two Phases Systems With Deep Eutectic Solvents

Farias¹,

Sosa

Mafra³

2018

Anais Do III Simpósio Paranaense De Modelagem, Simulação E Controle De Processos - SIMPROC 2018

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Liquid-liquid equilibrium (LLE) data used in this work were previously obtained by our group research. The quaternary systems were composed to cholinium chloride: glucose + poly(propylene)glycol (400 gmol-1) + H2O at 298.15 K. The Non-Random Two-Liquid (NRTL) model has been used to fit the DES-based aqueous two-phase systems. The interaction parameters of the models were estimated. The liquid−liquid equilibrium (LLE) experimental data were well correlated to the activity coefficients of the NRTL model, and the mean deviations were less than 1,1%.

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Formation of Aqueous Two‐Phase Systems Using Potassium Salt and Deep Eutectic Mixtures for Extraction of Proteins

2023

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Liquid‐liquid extraction such as an aqueous two‐phase system (ATPS) is considered a promising method in the biotechnology field for extraction of biomolecules. The binary mixture of polyethylene glycol (PEG)/salt is the most common ATPS. The ability of eutectic mixture‐based ATPS to fractionate protein macromolecules remains not well understood. Here, the role of hydrogen bond donors (HBDs) in eutectic mixtures was investigated in relation to the phase formation ability and extraction efficiency of protein. Both potassium salt and an eutectic combination were used to prepare the ATPSs. Choline chloride/urea aqueous two‐phase separation proved to be the most effective method for protein extraction. The creation of a two‐phase system and the efficiency with which a protein can be extracted from a crude solution are both affected by the choice of HBD.

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Study of the pseudo-ternary aqueous two-phase systems of deep eutectic solvent (choline chloride:sugars) + K2HPO4 + water

Cited by 78 publications

References 41 publications

Deep eutectic solvents aqueous two-phase system based ultrasonically assisted extraction of ursolic acid (UA) from Cynomorium songaricum Rupr.

Deep eutectic solvents aqueous two-phase system based ultrasonically assisted extraction of ursolic acid (UA) from Cynomorium songaricum Rupr.

Thermodynamic Modeling of Pseudoternary Aqueous Two Phases Systems With Deep Eutectic Solvents

Formation of Aqueous Two‐Phase Systems Using Potassium Salt and Deep Eutectic Mixtures for Extraction of Proteins

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