Study of the selectivity of inorganic anions in hydro-organic solvents using indirect capillary electrophoresis

Diress, Abebaw G.; Lucy, Charles A.

doi:10.1016/j.chroma.2004.12.004

Cited by 13 publications

(11 citation statements)

References 48 publications

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“…Previously, we showed that CTAB and DDAB can be used as dynamic coatings in buffers containing up to 60% MeOH [22,36]. However, these EOF modifiers must be maintained in the run buffer.…”

Section: Ddab-coating Stability In Meoh-water Buffersmentioning

confidence: 98%

Semipermanent capillary coatings in mixed organic–water solvents for CE

2007

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This report describes the creation of semipermanent capillary coatings that are compatible with organic-water solvent systems in CE. The coatings are created by simply rinsing the fused-silica capillary with long double-chain cationic surfactants, such as dimethyl-ditetradecyl ammonium bromide (2C(14)DAB), dihexadecyldimethyl ammonium bromide (2C(16)DAB), and dimethyldioctadecyl ammonium bromide (2C(18)DAB). These surfactants generate semipermanent bilayer coatings on the capillary surface, which display a high degree of stability in buffers containing up to 60% v/v of organic solvents, such as methanol and ACN. The coating stability increases with increasing hydrophobicity of the surfactant, i.e., with increasing chain length. For instance, the EOF changes by only 1.2% in a 2C(18)DAB-coated capillary after 130 capillary volumes of rinsing with 60% v/v methanol containing buffer. The bilayer coatings allow separations to be performed without the need to regenerate the coating between runs or to maintain the EOF modifier in the run buffer. Rapid separations (<2 min) of anions and basic drugs with migration time reproducibility of less than 0.5% RSD and efficiencies of 0.4-0.6 million plates/m are obtained. In addition, selectivity changes for small anions and cationic drugs are also observed when the organic solvent content is adjusted.

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“…Previously, we showed that CTAB and DDAB can be used as dynamic coatings in buffers containing up to 60% MeOH [22,36]. However, these EOF modifiers must be maintained in the run buffer.…”

Section: Ddab-coating Stability In Meoh-water Buffersmentioning

confidence: 98%

Semipermanent capillary coatings in mixed organic–water solvents for CE

2007

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“…In their fundamental paper [115], Porras and Kenndler have demonstrated that formamide has some interesting properties when used as solvent to the BGE, such as a low dependence of the ionic mobilities and longitudinal diffusion on the ionic strength. Significant changes in selectivity for common inorganic anions upon increasing the percentage of methanol in the BGE were observed by Diress and Lucy [116,117]. Metal ions [118][119][120][121] or their inorganic and organic forms [122] can be well separated by NACE, methanol being the most appropriate solvent; however, peak shapes and efficiencies remained marginal.…”

Section: Nonaqueous Mediamentioning

confidence: 96%

Recent trends in CE of inorganic ions: From individual to multiple elemental species analysis

Timerbaev

2007

Electrophoresis

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The major methodological developments in CE related to inorganic analysis are overviewed. This is an update to a previous review article by the author (Timerbaev, A. R., Electrophoresis 2004, 25, 4008-4031) and it covers the review work and innovative research papers published between January 2004 and the first part of 2006. As was underlined in that review, a growing interest of analytical community in providing elemental speciation information found a sound response of the CE method developers. Presently, almost every second research paper in the field of interest deals with element species analysis, the use of inductively coupled plasma MS detection and biochemical applications being the topics of utmost research efforts. On the other hand, advances in general methodology traditionally centered on a CE system modernization for improvements in sensitivity and separation selectivity have attracted less attention over the review period. While there is no indication that inorganic ion applications would surpass by the developmental rate the more matured analysis of organic analytes, CE can now be seen as an analytical technique to be before long customary in a number of inorganic analysis arenas.

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“…First, the coelectroosmotic separation caused the anions to be eluted from the capillary within a short time, which often cannot offer a sufficiently wide migration window and good resolution. Second, organic solvents were often required to be used as buffer modifier to improve the separation efficiency [16,17]. Therefore, development of highly efficient, environment friendly methods for the analysis of inorganic anions in CE is still of great importance.…”

Section: Introductionmentioning

confidence: 99%

Use of 1‐alkyl‐3‐methylimidazolium‐based ionic liquids as background electrolytes in capillary electrophoresis for the analysis of inorganic anions

Zhu

2008

J of Separation Science

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Separation of inorganic anions in CE is often a challenging task because the electrophoretic mobilities of inorganic anions are comparable to or even greater than the EOF mobility. In this study, we present the use of ionic liquids (ILs) as background electrolytes (BGEs) in CE of inorganic anions. The 1-alkyl-3-methylimidazolium-based ILs as BGEs dynamically coated the capillary wall and induced a reversed EOF. This allowed the anions to comigrate with the EOF and yielded a rapid separation. Increasing the alkyl chain length of the ILs and BGE concentration can significantly improve the separation resolution. With 40 mM 1-butyl-3-methylimidazolium tetrafluoroborate as BGE, good separations of five model anions (Br-, I-, NO2(-), NO3(-), and SCN-) were achieved in a range of buffer pH values. The separation efficiency was as high as 34 600-155 000, and the RSDs of the migration times were less than 0.8% (n = 5).

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Study of the selectivity of inorganic anions in hydro-organic solvents using indirect capillary electrophoresis

Cited by 13 publications

References 48 publications

Semipermanent capillary coatings in mixed organic–water solvents for CE

Semipermanent capillary coatings in mixed organic–water solvents for CE

Recent trends in CE of inorganic ions: From individual to multiple elemental species analysis

Use of 1‐alkyl‐3‐methylimidazolium‐based ionic liquids as background electrolytes in capillary electrophoresis for the analysis of inorganic anions

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