Study of the Serum Copper Levels in Patients with Major Depressive Disorder

Styczeń, Krzysztof; Sowa-Kućma, Magdalena; Siwek, Marcin; Dudek, Dominika; Reczyński, Witold; Misztak, Paulina; Szewczyk, Bernadeta; Topór-Mądry, Roman; Opoka, Włodzimierz; Nowak, Gabriel

doi:10.1007/s12011-016-0720-5

Cited by 55 publications

(25 citation statements)

References 30 publications

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“…No differences in Cu concentrations were demonstrated between the BD and MD [44]. The Cu levels were found similar in depressive patients (both with a current depressive episode and in remission) and HC group [45]. Elevated levels of blood Cu were reported in depressive disorder with a probable role of Cu as a biomarker of depression by a recent review [46].…”

Section: Discussionmentioning

confidence: 89%

Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Tunç

Atagün

Başbuğ

et al. 2019

Psychiatry and Clinical Psychopharmacology

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OBJECTIVE: In this study, we aimed to study copper metabolism in schizophrenia, bipolar disorder, major depression compared with healthy control. METHODS: This is a single-centered cross-sectional study. The patients with schizophrenia (n = 36), bipolar disorder (n = 37), major depression (n = 40), and healthy control (n = 32) were included in the study. All participants were initially evaluated by a clinical psychiatrist to confirm the appropriate diagnosis using the Structured Clinical Interview for Diagnostic and Statistical Manuel of Mental Disorders-IV (DSM-IV) Axis I Disorders (SCID-I). Serum copper level, ceruloplasmin mass, and ceruloplasmin-ferroxidase activity were measured. One-way ANOVA and Kruskal-Wallis Tests were performed for statistical analyses. RESULTS: Serum ceruloplasmin-ferroxidase activity (χ 2 = 9.11, p = 0.028) demonstrated a significant statistical difference in all groups compared with the control group. Serum ceruloplasmin-ferroxidase activity of the bipolar disorder group was significantly higher than the healthy control group (p = 0.012), major depression group (p = 0.027), and the schizophrenia group (p = 0.019). Erythrocyte sedimentation rate (ESR) (p = 0.028) and waist circumference (p = 0.005) in bipolar disorder group, and the C-reactive protein (CRP) (p < 0.001) and cholesterol (p = 0.043) in the schizophrenia group were found as the determinants of ceruloplasmin-ferroxidase activity. CONCLUSION: In this study, ceruloplasmin-ferroxidase activity is higher in all groups in comparison to the healthy control. The significantly higher ceruloplasmin-ferroxidase activity was shown in bipolar disorder followed by the major depression and schizophrenia. The ceruloplasmin-ferroxidase activity was correlated with erythrocyte sedimentation rate in the bipolar disorder group and with C-reactive protein in the schizophrenia group. Therefore, the ceruloplasmin-ferroxidase activity may be an encouraging candidate in the neuro-immune modulation and become a reliable clinical tool for demonstrating the strong association of inflammation in these disorders.

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Section: Discussionmentioning

confidence: 89%

Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Tunç

Atagün

Başbuğ

et al. 2019

Psychiatry and Clinical Psychopharmacology

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“…Studies have observed a potential association between levels of free copper in blood and cognitive impairment [28]. Although inconclusive results have been reported [29], one study also suggests a relationship between elevated copper levels and depression [30]. The identi ed adverse reactions illustrate the importance of follow-up consultations with the aim to identify those who develop adverse reactions.…”

Section: Discussionmentioning

confidence: 99%

Adverse reactions of the copper intrauterine device and related consequences: experiences described in discussion boards

Fernaeus¹,

Molin²,

Georgsson³

et al. 2020

Preprint

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Background The copper intrauterine device is a recommended and effective method for contraception. Recently, agencies have seen an increase in spontaneous reports of adverse reactions, and analysis of messages in discussion boards may lead to new insights. The aim was to explore experiences of adverse reactions related to the copper intrauterine device described by posters in Swedish public discussion boards. Methods Messages containing descriptions of client experiences were collected via Swedish public discussion boards about sexual and reproductive health, identified through searches in Google. Posters with experience of adverse reactions were included (n = 145 unique posters) and their messages were inductively analyzed with qualitative manifest content analysis. Results Four categories were derived from the data; physical reactions, psychological reactions, intensity of adverse reactions, and consequences of adverse reactions. Adverse reactions were identified as physical reactions (15 sub-categories illustrating the different types of reactions) and psychological reactions (5 sub-categories illustrating the different types of reactions). Posters expressed significant intensity of adverse reactions, such as the reaction being awful, extreme, and traumatic. Some had such a negative experience of adverse reactions that they would never again consider a copper intrauterine device and that they would never had it inserted if they knew about the experienced adverse reactions. While some decided to accept adverse reactions and keep the device, others did not and removed it. Adverse reactions had negative effects on sexual health, partner relationship, and fears and worries, including fear to seek gynecologic care because of a traumatic and painful insertion. Conclusions Descriptions of both expected and unexpected adverse reactions of the copper intrauterine device can be found in discussion boards, some which can feel like being of high intensity and have burdensome consequences in the lives of clients. Midwives, nurses and physicians working in contraceptive counseling need to ensure that clients are sufficiently informed about possible adverse reactions and followed-up accordingly. More research is needed that further investigates adverse reactions of the copper intrauterine device and the impact such reactions may have for clients.

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“…They also performed another study (Varconyl et al, 2011) and reported a high prevalence of copper deficiency and its association with iron status, which is consistent with our results. The mean copper level is normally between 100-130 mg/100 ml of the serum (Styczeń et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Copper and Zinc Levels in Myelodysplastic Syndrome Patients versus Healthy Subjects

Moazed

Jafari

RashidiNezhad

et al. 2020

Asian Pac J Cancer Prev

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Background: Myelodysplastic syndrome (MDS) is a heterogeneous hematological disease and certain serum factors are assumed to be involved in its pathogenesis and progression. Given this, our aim was to comparatively investigate the copper, zinc, and iron levels in MDS patients and healthy individuals. Methods: This case-control study was conducted on 31 patients with MDS (according to the WHO criteria after investigating laboratory tests such as peripheral blood smear and bone marrow aspiration) attending Bahonar Hospital, Kerman, Iran, and 31 healthy subjects from 2016 to 2018. The levels of copper, ceruloplasmin, zinc, ferritin, and iron were compared between the two groups. Results: Among the MDS patients, five individuals (16.13%) had low serum copper level (mean: 67.8 ± 4.35 µg/dl). Serum copper level was 111.3 ± 27.7 and 138.3 ± 26.6 in case and control groups, respectively (P = 0.0001). The serum zinc level and bone marrow iron level were also significantly different between the two groups (P < 0.05). Conclusion: Overall, it can be concluded that because only a small proportion of the MDS patients enrolled in this study were found to have lower copper levels compared with the MDS patients population, further studies with a larger sample size and also clinical trials in MDS patients with serum zinc, and copper deficiency are recommended, and post-treatment hematological reassessment would also be beneficial to achieving more definitive results.

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Study of the Serum Copper Levels in Patients with Major Depressive Disorder

Cited by 55 publications

References 30 publications

Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Serum ceruloplasmin-ferroxidase activity in bipolar disorder is elevated compared to major depressive disorder and schizophrenia: a controlled study

Adverse reactions of the copper intrauterine device and related consequences: experiences described in discussion boards

Copper and Zinc Levels in Myelodysplastic Syndrome Patients versus Healthy Subjects

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