Study of the solid phase extraction and spectrophotometric determination of nickel using 5-(4′-chlorophenylazo)-6-hydroxypyrimidine-2,4-dione in environmental samples

Amin, Alaa S.; Al-Attas, Amirah S.

doi:10.1016/j.jscs.2011.02.018

Cited by 30 publications

(16 citation statements)

References 51 publications

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“…The estimate of equilibrium log K is ∼6, which fits comfortably in the range of solute-sorbent equilibria that are commonly reported for SPE. 50,51 Elution Solvent Optimization. After developing a DMFmagnetic bead-SPE method, we turned our attention to optimization of elution solvents.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Attractive Design: An Elution Solvent Optimization Platform for Magnetic-Bead-based Fractionation Using Digital Microfluidics and Design of Experiments

Lafrenière

Mudrik

et al. 2015

Anal. Chem.

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There is great interest in the development of integrated tools allowing for miniaturized sample processing, including solid phase extraction (SPE). We introduce a new format for microfluidic SPE relying on C18-functionalized magnetic beads that can be manipulated in droplets in a digital microfluidic platform. This format provides the opportunity to tune the amount (and potentially the type) of stationary phase on-the-fly, and allows the removal of beads after the extraction (to enable other operations in same device-space), maintaining device reconfigurability. Using the new method, we employed a design of experiments (DOE) operation to enable automated on-chip optimization of elution solvent composition for reversed phase SPE of a model system. Further, conditions were selected to enable on-chip fractionation of multiple analytes. Finally, the method was demonstrated to be useful for online cleanup of extracts from dried blood spot (DBS) samples. We anticipate this combination of features will prove useful for separating a wide range of analytes, from small molecules to peptides, from complex matrices.

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Section: ■ Experimental Sectionmentioning

confidence: 99%

Attractive Design: An Elution Solvent Optimization Platform for Magnetic-Bead-based Fractionation Using Digital Microfluidics and Design of Experiments

Lafrenière

Mudrik

et al. 2015

Anal. Chem.

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“…5-(2`,4`-dimethylphenylazo)-6-hydroxy pyrimidine-2,4-dione (DMPAHPD) dye has been used for spectrophotometric determination of samarium(III) and others [27][28][29][30][31]. In this paper, the fabrication of an optode for determination of low levels of mercury is described in which the sensing reagent is (DMPAHPD) immobilized on triacetylcellulose membrane.…”

Section: Page 5 Of 55mentioning

confidence: 99%

Application of a triacetylcellulose membrane with immobilizated of 5-(2′,4′-dimethylphenylazo)-6-hydroxypyrimidine-2,4-dione for mercury determination in real samples

Amin

2015

Sensors and Actuators B: Chemical

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“…1 It is a signicant divalent cation in biological systems and plays central roles in the human body, for example, inuencing DNA synthesis, microtubule polymerization, gene expression, apoptosis, immune system function, and activity of enzymes such as carbonic anhydrase and matrix metalloproteinase. 9,10 In spite of these methods, difficulties remain in the analysis of the trace amounts of metals in different samples. Consequently, due to the importance of Zn 2+ determination at ultra-trace levels in a variety of pharmacological, biological, and environmental samples, development of a sensitive and selective analytical techniques for determining ultra-trace levels of zinc as a toxic metal is a very important task and is still a challenging issue.…”

Section: Introductionmentioning

confidence: 99%

Response surface methodology based on central composite design as a chemometric tool for optimizing dispersive liquid–liquid microextraction for determining ultra-trace amounts of zinc in oil and water samples

et al. 2016

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The reliable and rapid dispersive liquid-liquid microextraction (DLLME) was applied to highly selective preconcentration and extraction of ultra-trace Zn 2+ levels as a prior step to its determination by graphite furnace atomic absorption spectrometry (GFAAS). In this method, N,N-phenylenebis (salicylideaminato) (L) was used as a Zn 2+ selective complexing agent. A mixture containing a dispersing solvent (methanol), extraction solvent (chloroform), and proper levels of the chelating agent was rapidly injected into the 5 mL aqueous sample containing 2.5% (w/v) sodium chloride and Zn 2+ , which resulted in a cloudy solution. After 5 min of centrifuging at 5500 rpm, the fine droplets of extraction solvent were sedimented at the bottom of the conical test tube. The variables of interest in the DLLME method, such as extraction and dispersion solvent types and volumes, sample solution pH, extraction time, chelating agent concentration, and ionic strength, were investigated and optimized using a chemometrics approach. Then, after the preliminary experiment, the factors presenting significant positive effects on the analytical response (pH, salt effect, extraction solvent, and ligand concentration) were considered in a further response surface methodology based on central composite design to optimize the operational conditions for DLLME. It was found that extraction time and common interfering ions had no significant effect on the extraction recovery. Under the selected conditions, the linear range was 0.2-100 ng mL À1 and limit of detection was 0.05 ng mL À1 for most of the analytes. The relative standard deviation (R.S.D) for 2 ng mL À1 Zn 2+ was 4.87% (n ¼ 15) and the enrichment factor was 167 from 5 mL of the aqueous sample. In the optimum conditions, the present method was successfully applied to the preconcentration and Zn 2+ determination in different natural oil and water samples. Fig. 1 (A) Chemical structure of the ligand. (B) Absorbance spectra of a 1 Â 10 À6 mol L À1 solution of L in methanol at different Zn 2+ concentrations. (C) Influence of pH on the Zn 2+ recovery; extraction conditions: sample volume, 5 mL; dispersing solvent volume, 450 mL methanol; extraction solvent, 35 mL CHCl 3 ; chelating agent 1 Â 10 À6 mol L À1 ; pH ¼ 6; salt concentration: 2.5% (w/v) and 2.00 ng mL À1 Zn 2+ concentration. Anal. MethodsThis journal is

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Study of the solid phase extraction and spectrophotometric determination of nickel using 5-(4′-chlorophenylazo)-6-hydroxypyrimidine-2,4-dione in environmental samples

Cited by 30 publications

References 51 publications

Attractive Design: An Elution Solvent Optimization Platform for Magnetic-Bead-based Fractionation Using Digital Microfluidics and Design of Experiments

Attractive Design: An Elution Solvent Optimization Platform for Magnetic-Bead-based Fractionation Using Digital Microfluidics and Design of Experiments

Application of a triacetylcellulose membrane with immobilizated of 5-(2′,4′-dimethylphenylazo)-6-hydroxypyrimidine-2,4-dione for mercury determination in real samples

Response surface methodology based on central composite design as a chemometric tool for optimizing dispersive liquid–liquid microextraction for determining ultra-trace amounts of zinc in oil and water samples

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