Study of the steroidogenic pathways involved in goat placental androgen and estrogen synthesis

Mondragón, J.A.; Valdéz, Ricardo; Gómez, Y.; Rosales, Ana M.; Romano, Marta

doi:10.1016/j.smallrumres.2012.02.020

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…In the majority of cases of early CAIS, due to the risk of gonadal tumor resulting from the ectopic gonad (5–10%), surgeons consider gonadectomy and subsequent puberty induction. As is well known, androgen is generated primarily by testes, and it is necessary for skeletal development because it is converted to estrogens . To protect bone mineral density and prevent the vaginal hypoplasia, women with CAIS need to remain on long‐term estrogen replacement.…”

Section: Discussionmentioning

confidence: 99%

Complete androgen insensitivity syndrome in juveniles and adults with female phenotypes

Wang

et al. 2014

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 99%

Complete androgen insensitivity syndrome in juveniles and adults with female phenotypes

Wang

et al. 2014

J of Obstet and Gynaecol

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“…) Finally, placental steroidogenesis has been recorded in a number of ruminants (Strauss, Martinez & Kiriakidou ; Hoffmann & Schuler ; Khatri ; Mondragon et al . ), making it feasible for placentally synthesized androgens to enter the foetal bloodstream. With testosterone of maternal origin, both sexes would likely be born with high concentrations that are rapidly depleted.…”

Section: Introductionmentioning

confidence: 99%

“…This is not true for all species, however. Hyenas have been shown to convert maternal D 4 -androstenedione (most likely of placental origin, Licht et al 1992) into foetal testosterone during gestation (Licht et al 1998) Finally, placental steroidogenesis has been recorded in a number of ruminants (Strauss, Martinez & Kiriakidou 1996;Hoffmann & Schuler 2002;Khatri 2011;Mondragon et al 2012), making it feasible for placentally synthesized androgens to enter the foetal bloodstream. With testosterone of maternal origin, both sexes would likely be born with high concentrations that are rapidly depleted.…”

Section: Introductionmentioning

confidence: 99%

Variation in early‐life testosterone within a wild population of red deer

et al. 2014

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Summary1. Individual differences in circulating hormone concentrations can affect life-history traits throughout an animal's life. Despite this, relatively little is known about the potential drivers or consequences of individual variation in hormone levels, particularly in early life. In animals showing maternal care, early development is often dependent on maternal characteristics and condition. It is therefore possible that individual hormone profiles early in life are dependent on condition-linked characteristics of the mother. 2. Using data from a long-term study of a wild red deer (Cervus elaphus) population, we investigated the potential role of maternal effects on offspring early-life testosterone concentrations and the relationship between these testosterone levels and juvenile survival. 3. Most of the variation among neonatal calves was accounted for by their age and sex. Both sexes showed a steep decline in testosterone levels within 24 h of birth, although concentrations were consistently higher in males, and females showed a steeper decline in testosterone after 24 h. Furthermore, male calves born in years after a brother had lower concentrations than those who were preceded by a sister or who were firstborns. We did not find any evidence of repeatable differences among mothers in the testosterone levels of their calves, but there was significant interannual variation across the 17-year study period. 4. We also found early-life testosterone to be associated with calf survival, but only among individuals already at higher mortality risk: male calves born to first-time mothers were increasingly less likely to survive with higher neonatal testosterone concentrations. 5. These results support the suggestion that a neonate's circulating testosterone concentrations can be linked to both individual and maternal characteristics and that interindividual variation in these levels can have implications for juvenile fitness within a wild mammal population.

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Evidence for existence of insulin-like factor 3 (INSL3) hormone-receptor system in the ovarian corpus luteum and extra-ovarian reproductive organs during pregnancy in goats

et al. 2021

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Study of the steroidogenic pathways involved in goat placental androgen and estrogen synthesis

Cited by 3 publications

References 20 publications

Complete androgen insensitivity syndrome in juveniles and adults with female phenotypes

Complete androgen insensitivity syndrome in juveniles and adults with female phenotypes

Variation in early‐life testosterone within a wild population of red deer

Evidence for existence of insulin-like factor 3 (INSL3) hormone-receptor system in the ovarian corpus luteum and extra-ovarian reproductive organs during pregnancy in goats

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