Study of the structure of free radicals in gamma: irradiated amino acid derivatives

Abstract

Electron paramagnetic resonance spectroscopy has been used for the study of the free radicals produced in the powders of L-arginine monohydrochloride, ala-ala and DL-β-leucine gamma-irradiated at room temperature.The structures of the radicals formed in compounds were determined as NH 2 (NH)NHĊHCH 2 CH 2 CH(NH 2 )COOH, CH 3Ċ HCOOH and (CH 3 ) 2Ċ CH(NH 2 )CH 2 COOH respectively. The paramagnetic species were found to be stable at room temperature more than three months. It was determined that unpaired electron interacted with nearby protons and 14 N nucleus in these radicals. The g values of the radicals and the hyperfine structure constants of the free electron were also measured. These results were compared with the earlier studies in amino acid and derivatives radicals and discussed.

Effect of Gamma Radiation on Novel Gelatin Extracted from Camel Skin for Pharmaceutical Application

“…The species found in the paramagnetic field were determined as anions radical with an unpaired electron positioned on the carboxyl carbon (Silva et al, 2008). It is seen that the hyperfine constants are slighter than anion radicals of other amino acids (Aydin, 2010). At around 3300 G (g-factor = 2.0), the peak is related to glycine residue, appeared~•CH as a minor product.…”

“…At around 3300 G (g-factor = 2.0), the peak is related to glycine residue, appeared~•CH as a minor product. The other compound of homolytic scission is ~ (O) C• radical that demonstrated an important singlet (Aydin, 2010). The methylene group is capable to offer hydrogen atoms to both radicals •~ which leads to the ~CH formation.…”

EPR analysis of gamma irradiated single crystal cimetidine

“…Also, EPR provides the most complete information about the structure and the motional behavior of radicals [40][41][42].…”