In
this paper, a new Mn-based metal–organic framework [UoB-6]
was obtained via a one-step ultrasonic irradiation
method with the ligand (H2bdda: 4,4′-(1,4-phenylenebis(azaneylylidene))bis(methaneylylidene))dibenzoic
acid. The structural integrity of the synthesized BioMOF-Mn was corroborated
by FT-IR, EDX, ICP, XRD, TEM, DLS, FESEM, and BET-BJH analyses. The
aerobic oxidative domino reaction of benzyl alcohols or aldehydes
with dimedone derivatives was performed in the presence of the UoB-6
catalyst to produce xanthene derivatives in good yields. Hot filtration
and Hg poisoning tests proved the heterogeneous nature of the catalyst.
Novel synthesized xanthene-based bis-aldehydes were introduced as
potent HDAC1 inhibitors according to molecular docking calculations.
Finally, the inhibitory activities of Mn-MOF nanoparticles were evaluated
on Escherichia coli and Candida albicans. The MIC, MBC, and MFC values were
determined from 2048 to 4096 μg·mL–1 according
to antimicrobial susceptibility testing methods. The inhibitory effects
of antimicrobial agents can be exacerbated when loaded on BioMOFs.