Study of thyroid dysfunction in people living with HIV in Nepalese population undergoing antiretroviral therapy: a cross-sectional study

Sah, Uday Kant; Ansari, Mehraj; Sah, Anil K; Chaudhary, Priyanka; Gupta, Somesh; Kumar, Pawan; Sah, Jay Prakash

doi:10.1177/09564624221147963

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Venous blood samples were aseptically collected from the participants as described previously [ 16 ], and the plasma was screened for anti-HIV antibodies using Retroquic HIV test kit (Qualpro Diagnostics, Verna, Goa, India). Remaining plasma samples were stored at −80 °C until tested for HCV.…”

Section: Methodsmentioning

confidence: 99%

HCV Co-Infection and Its Genotypic Distribution in HIV-Infected Patients in Nepalese Population

Sah

Ansari³

et al. 2023

TropicalMed

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Hepatitis C Virus (HCV) co-infection and its genotypic distribution in people living with Human Immunodeficiency Virus (HIV) show global inconsistency. Therefore, the present study aimed to investigate the prevalence and genotypic distribution patterns of HCV, along with viral load, in people living with HIV. This cross-sectional study was conducted at SRL Diagnostics Nepal, Pvt. Ltd. in 203 HIV-seropositive patients attending the Tribhuvan University Teaching Hospital (TUTH), Maharajgunj, Kathmandu, Nepal from October 2021 to May 2022. The viral load and HCV genotypes were estimated from RNA extracted from the blood sample (plasma) of PLHIV by using a standard Q-PCR protocol. HCV infection was considered as a core variable, whereas covariates used for this study were duration of HIV infection, age, sex, and ART regimen. Out of total 203 PLHIV, the estimated prevalence of HCV co-infection was 115 (56.6%). Male gender was a unique characteristic associated with a high prevalence of HCV co-infection compared to females. The HCV viral load among PLHIV ranged from 34 to 3,000,000 IU/mL. Among HCV co-infected PLHIV, 56 (48.69%) had a low level of HCV viral load. Interestingly, only 3 (2.6%) patients had an HCV viral load higher than 3,000,000 IU/mL. Diverse HCV genotypes were found in the population, including genotypes 1, 1a, 3a, 5a, and 6. However, genotype 3 was the most prevalent HCV variant among HCV-co-infected PLHIV, with a distribution of 36 (61.1%) and viral load ranging from 34 to 3000 IU/mL. HCV co-infection is frequent in the Nepalese population of people living with HIV, particularly due to HCV genotypic variant 3. The findings of this study could be useful for the management and clearance of the HCV co-infection in PLHIV, aiming to provide a good quality of life.

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Section: Methodsmentioning

confidence: 99%

HCV Co-Infection and Its Genotypic Distribution in HIV-Infected Patients in Nepalese Population

Sah

Ansari³

et al. 2023

TropicalMed

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“…3 In patients with advanced HIV disease, variety of systemic opportunistic conditions that infect or infiltrate the thyroid can decrease or increase T4 secretion. 4 Less frequently, hypothalamic pituitary failure caused by central nervous system infections such as Cryptococcosis or Toxoplasmosis has been reported. 5 Thyroid dysfunctions in HIV-positive individuals can result from gland destruction by opportunistic pathogens (Pneumocystis jirovecii or Cytomegalovirus).…”

Section: Introductionmentioning

confidence: 99%

Thyroid dysfunction in human immuno-deficiency virus infected patients: a non-randomized, cross-sectional, single-center study

Mujawar

Byakod²,

P.³

et al. 2023

Int J Res Med Sci

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Background: Increasing prevalence of thyroid dysfunction has been reported in human immuno-deficiency virus (HIV)-infected patients. However, there is insufficient evidence to recommend routine thyroid screening of asymptomatic individuals. Hence, this study was undertaken in an attempt to resolve these issues. Objectives of this non-randomized, cross-sectional, single-center study was to study thyroid function in HIV positive patients at various stages of disease. Methods: This single-center study was carried out at Al-Ameen Medical College Hospital and Government District Hospital Bijapur, Karnataka, India from December 2020 to December 2022. The final selected study population included newly diagnosed adult and adolescent (17-60 years) HIV+ patients was composed of 100 participants of either gender. Patients were interviewed and enrolled in the study after examining in detail according to the proforma and then by taking their written consent and explaining the purpose of the study. The thyroid hormone assays (S. TSH, FT3 and FT4) were done by chemiluminescence immuno assay (CLIA) using ADVIA Centaur-equipment. Results: Overall mean age was 36 years (range in years: 17–66 years) and 66 patients (66%) were males. Male: female ratio of 1.94:1 was recorded. In the 50 patients having acquired immuno-deficiency virus (AIDS), FT3 levels ranged from 0.230 to 4.0 picogram/ml with a mean of 2.131+0.9826 picogram/ml. In 50 patients having AIDS, the FT4 levels ranged from 0.30 to 1.90 nanogram/dI with a mean 1.179±0.4484 nanogram/dl. Conclusions: All forms of thyroid dysfunction were observed.

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South Asian Endocrinology: Challenges and Concerns, Collaboration and Consolidation

Bhattacharya,

Kalra

2023

Indian Journal of Endocrinology and Metabolism

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The practice of endocrinology in South Asia poses many challenges but simultaneously offers unique opportunities. The population in this region is predisposed to diabetes and cardiovascular disease at a much lower body mass index compared to Caucasians. Dietary deficiencies, higher prevalence of infection and distinct environmental and genetic factors further complicate the presentation of endocrine disorders. Over the past few decades, important breakthroughs have been made to confront these challenges. Collaboration among the endocrine fraternity of the South Asian countries will help to consolidate these gains and pave the way forward for a healthier region.

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Study of thyroid dysfunction in people living with HIV in Nepalese population undergoing antiretroviral therapy: a cross-sectional study

Cited by 3 publications

References 22 publications

HCV Co-Infection and Its Genotypic Distribution in HIV-Infected Patients in Nepalese Population

HCV Co-Infection and Its Genotypic Distribution in HIV-Infected Patients in Nepalese Population

Thyroid dysfunction in human immuno-deficiency virus infected patients: a non-randomized, cross-sectional, single-center study

South Asian Endocrinology: Challenges and Concerns, Collaboration and Consolidation

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