Study of Thyroid Proile in Patients of Recurrent Abortions

Barapatre, Amit Ramesh; Vaidya, Seema

doi:10.14260/jemds/1665

Cited by 3 publications

(6 citation statements)

References 14 publications

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“…Our study shows the mean TSH levels 29.84±21.13mIU/L(hypothroid), 2.67±1.12mIU/L which is similar with study done by the Dinesh K Dhanwal et al [3] showing mean TSH levels 3.16 (11.17)mIU/L. The results of our study is also comparable with the results of the study done by Amit R Baptre et al [7] and Alessandro Dal et al [24] showing mean TSH levels 10.024±4.13mIU/L, 17.8±1.23mIU/L. An another study done by AS Khalid et al 21 also demonstrated high mean TSH levels > 2.5mIU/L which is also similar to result of our study.…”

Section: Discussionsupporting

confidence: 92%

“…Hypothyroidism during pregnancy occurs in 1/1600-1/2000 (0.06-0.05) [6]. Probably the rarity of hypothyroidism in pregnancy is due to the fact that hypothyroid women have higher prevalence of anovulatory cycles and in case of conception they have higher rate of fetal loss in first trimester [7] [8]. The world wide prevalence of subclinical hypothyroidism ranges from 1-10% [9].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of hypothyroidism in women with recurrent pregnancy loss in the first trimester in the Indian rural population

Verma

Mathur

Sahni³

2016

Obs Gyne Reivew J Obstet Gynecol

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Aim:To determine the frequency of hypothyroidism in women with recurrent pregnancy loss in first trimester in the Indian rural population. Study Design: The study included 50 women with one successful pregnancy and no history of miscarriages were selected as a control and total of 50 similar age group of pregnant women with recurrent pregnancy loss in gestational age up to ≤ 12 weeks verified by pregnancy test or ultrasonography. Method: Levels of thyroid hormones T3, T4 and TSH were estimated in pregnant and non pregnant women with recurrent pregnancy loss and controls. Result: The hypothroidism was found to be more significant cause of recurrent pregnancy loss in women as comparative to the euthyroid women. Conclusions: The study demonstrates that hypothyroidism has a statistically significant relationship with recurrent pregnancy loss in the first trimester and suggests that diagnosis of hypothyroidism could help couples with recurrent pregnancy loss to have a successful outcome in subsequent pregnancies.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Prevalence of hypothyroidism in women with recurrent pregnancy loss in the first trimester in the Indian rural population

Verma

Mathur

Sahni³

2016

Obs Gyne Reivew J Obstet Gynecol

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“…Hypothyroidism in women diagnosed before pregnancy is 1%. Maternal and foetal problems in this cohort were shown to be higher 3 . In the study by Amit R Barapatre, hypothyroid individuals who suffered repeated pregnancy losses were 8 weeks in age 7 (11.67%), 8-16 weeks in 10 (16.67%), 16-22 weeks in 4 weeks (6.67 percent) 3 .…”

Section: Introductionmentioning

confidence: 62%

“…Maternal and foetal problems in this cohort were shown to be higher 3 . In the study by Amit R Barapatre, hypothyroid individuals who suffered repeated pregnancy losses were 8 weeks in age 7 (11.67%), 8-16 weeks in 10 (16.67%), 16-22 weeks in 4 weeks (6.67 percent) 3 . The diagnosis of hypothyroidism in pregnancy is complicated, given that most clinical signs are unspecific (asthenia, lethargy) or may conceal obstetric symptoms (increase in weight, altered appetite).…”

Section: Introductionmentioning

confidence: 62%

Thyroid Disorders in Pregnancy and Prevalence of Subclinical Hypothyroidism in Recurrent Early Pregnancy Losses

Younus¹,

Khan²,

Naz³

et al. 2021

PJMHS

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Objective: Determine the frequency of hypothyroidism in recurrent pregnancy loss. Study Design: This is cross sectional. Place and Duration of Study: This study was conducted at Obstetrics and Gynaecology department of Dow Medical University & Hospital, Ojha Campus, Karachi, from 7th July 2018 to 6th July 2019. Methodology: This study was conducted on 83 patients. Detailed history was taken from all the patients with special regard to demographics like age, parity and recurrent pregnancy loss. A 3 ml venous blood was drawn by the staff on duty and sent to institutional laboratory for TSH and free T4 level. TSH values more than 4.5 μIU/L and normal free T4 level (0.7 to 1, 8 ng/ml) were considered as hypothyroidism. All pregnant female was between age 20-35 years with > 6 months gestational age and history of parity 3 and gravida 4 were included in the study. Exclusion criteria were known case of hypothyroidism or history of taking medication for hypothyroidism, history of Hypertension and DM. Results: This study was conducted on 83 patients. There was wide variation of age ranging from a minimum of 20 years to 35 years. The mean age was 28.4+ 4.49 years. Mostly patients were parity 3 and gravid 4 in 55(66.26%) cases followed by parity 4 and gravid 4 in 28(33.73%) cases. Gestational age was measured on ultrasound ranging from 8 weeks to 22 weeks. The mean gestational age was 14.20+4.71 years. Patient's thyroid profile mean Thyroid-stimulating hormone (TSH) level was 2.39+1.66 mU/L, mean free T4 was 17.23+6.41 nmol/L and mean free T3 was 4.87+1.18 μmol/L. Observed hypothyroidism was in 11(13.3%) cases while rest of 72(86.7%) cases within normal range. Conclusion: We concluded that hypothyroidism is problem in recurrent pregnancy loss. 11(13.3%) cases Frequency of hypothyroidism in women with pregnancy, the possible role of thyroid functional disorders in etiology of at least some part of recurrent pregnancy loss, had emphasized the importance of thyroid functions tests screening as routine in all pregnancies. Keywords: Thyroid disease, Pregnancy outcome, Hypothyroidism.

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“…These findings are in consistence with the study of Barapatre and Vaidya that elevated serum TSH levels without alteration in T3 and T4 during pregnancy increases the risk for miscarriage in both first and second trimester. [ 20 ] Allan et al . also reported that women with TSH levels above 6 mIU/ml has a significant increased risk for still birth[ 21 ] and further risk of miscarriage increases by 15% for each 1 mIU/ml elevation of TSH level.…”

Section: Discussionmentioning

confidence: 99%

Correlation of enhanced oxidative stress with altered thyroid profile: Probable role in spontaneous abortion

Kaur

Gupta

Kaur

2017

Int J App Basic Med Res

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Background:Spontaneous abortion or miscarriage is defined as the loss of a clinically recognized pregnancy that occurs before 20 weeks of gestational age. Changes in thyroid function can impact greatly on reproductive function before, during, and after conception. Oxidative stress affects both implantation and early embryo development by modifying the key of transcription. Malondialdehyde (MDA) is a major breakdown product of split off from lipid peroxidation. Superoxide dismutase (SOD) is responsible for detoxification of superoxide anion and required for normal health and reproduction.Aim:The aim of this study was to define the involvement of thyroid hormones, MDA and SOD levels and to establish MDA levels as an index of lipid peroxidation in women with spontaneous abortion by comparing the results with healthy pregnant females as controls.Materials and Methods:A cross-sectional case-control study was designed with two groups of women with 30 each in healthy pregnancy and with spontaneous abortion.Results:Demographic characteristics such as maternal age, paternal age, gestational age, body mass index, waist-hip ratio as well as biochemical parameters such as blood pressure, hemoglobin (Hb), sugar levels were found to be similar in both the participating groups. Characteristics like gravida and parity were found to be higher in the study group and differ significantly from control group. Spontaneous abortion before 24 weeks of gestational age was found to be associated with significant increase in mean serum thyroid stimulating hormone (TSH) (P = 0.0115) and MDA (P = 0.0001) levels and a significant decrease in mean serum T3 (P = 0.0003) and SOD (P = 0.0005) levels. The linear (Pearson) correlation analysis demonstrated a significant positive correlation of TSH with MDA and negative correlation with SOD in women with spontaneous abortion.Conclusion:The study demonstrates that altered thyroid profile, increased lipid peroxidation in terms of increased MDA levels and decreased SOD levels might be involved in the termination of otherwise wanted pregnancy.

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Study of Thyroid Proile in Patients of Recurrent Abortions

Cited by 3 publications

References 14 publications

Prevalence of hypothyroidism in women with recurrent pregnancy loss in the first trimester in the Indian rural population

Prevalence of hypothyroidism in women with recurrent pregnancy loss in the first trimester in the Indian rural population

Thyroid Disorders in Pregnancy and Prevalence of Subclinical Hypothyroidism in Recurrent Early Pregnancy Losses

Correlation of enhanced oxidative stress with altered thyroid profile: Probable role in spontaneous abortion

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