Study of total phenol, flavonoids contents and phytochemical screening of various leaves crude extracts of locally grown Thymus vulgaris

Hossain, M. Amzad; AL-Raqmi, Khulood Ahmed Salim; AL-Mijizy, Zawan Hamood; Weli, Afaf M.; Al-Riyami, Qasim

doi:10.1016/s2221-1691(13)60142-2

Cited by 296 publications

(203 citation statements)

References 12 publications

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“…15,16 Twenty tests were carried out, as shown in Table 1. The total phenolic compound and reducing sugar contents were analyzed according to previous reports.…”

Section: Green Synthesis Of Gm-aunps and Gm-agnpsmentioning

confidence: 99%

Asymmetric dumbbell-shaped silver nanoparticles and spherical gold nanoparticles green-synthesized by mangosteen (<em>Garcinia mangostana</em>) pericarp waste extracts

Park¹,

Ahn²,

Park³

2017

IJN

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Mangosteen ( Garcinia mangostana ) pericarp waste extract was used to synthesize gold and silver nanoparticles by a green strategy. The extract was both a reducing and stabilizing agent during synthesis. Phytochemical screening of the extract was conducted to obtain information regarding the presence/absence of primary and secondary metabolites in the extract. The in vitro antioxidant activity results demonstrated that the extract had excellent antioxidant activity, which was comparable to a standard (butylated hydroxy toluene). Spherical gold nanoparticles (gold nanoparticles green synthesized by mangosteen pericarp extract [GM-AuNPs]) with an average size of 15.37±3.99 to 44.20±16.99 nm were observed in high-resolution transmission electron microscopy (HR-TEM) images. Most interestingly, the silver nanoparticles (silver nanoparticles green synthesized by mangosteen pericarp extract [GM-AgNPs]) had asymmetric nanodumbbell shapes where one tail grew from a spherical head. The average head size was measured to be 13.65±5.07 to 31.08±3.99 nm from HR-TEM images. The hydrodynamic size of both nanoparticles tended to increase with increasing extract concentration. Large negative zeta potentials (−18.92 to −34.77 mV) suggested that each nanoparticle solution possessed excellent colloidal stability. The reaction yields were 99.7% for GM-AuNPs and 82.8% for GM-AgNPs, which were assessed by inductively coupled plasma optical emission spectroscopy. A high-resolution X-ray diffraction pattern confirmed the face-centered cubic structure of both nanoparticles. Based on phytochemical screening and Fourier transform infrared spectra, the hydroxyl functional groups of carbohydrates, flavonoids, glycosides, and phenolic compounds were most likely involved in a reduction reaction of gold or silver salts to their corresponding nanoparticles. The in vitro cytotoxicity (based on a water-soluble tetrazolium assay) demonstrated that GM-AgNPs were toxic to both A549 (a human lung cancer cell) and NIH3T3 (a mouse fibroblast cell). The cytotoxicity of GM-AgNPs on A549 cells was related to apoptotic cell death. However, GM-AuNPs did not show any significant cytotoxicity to either cell. These results suggest that GM-AuNPs have the potential to be drug delivery vehicles or carriers for pharmaceutical and biomedical applications.

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“…15,16 Twenty tests were carried out, as shown in Table 1. The total phenolic compound and reducing sugar contents were analyzed according to previous reports.…”

Section: Green Synthesis Of Gm-aunps and Gm-agnpsmentioning

confidence: 99%

Asymmetric dumbbell-shaped silver nanoparticles and spherical gold nanoparticles green-synthesized by mangosteen (<em>Garcinia mangostana</em>) pericarp waste extracts

Park¹,

Ahn²,

Park³

2017

IJN

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“…According to [17] the most important bioactive compounds are flavonoids which may be responsible for the antibacterial activity of the plant crude extracts of Thymus vulgaris. The same authors further mentioned reports from several authors that flavonoids groups exhibited a wide range of biological activities such as antioxidant, anti-inflammatory, antimicrobial, anti-angionic, anticancer and anti-alergic.…”

Section: Phytochemical Constituents Of Herbal Tea Plantsmentioning

confidence: 99%

Phytochemical, Antimicrobial and Sensory Qualities of Herbal Tea Made from Sarcandra glabra and Drymis piperita

2018

Dec. 14-15, 2017 Kuala Lumpur (Malaysia)

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“…All the eluted fractions were tested for flavonoid content, the active fractions were pooled and air dried under sterile conditions. The concentrated dried powder subjected for qualitative confirmation of flavonoids using dimethyl sulfoxide as a dissolving solvent and quercetin as an internal standard [11].…”

Section: Isolation and Purification Of Flavonoids From The Plant Extrmentioning

confidence: 99%

Evaluation of Xanthine Oxidase Inhibitory Activity by Flavonoids From Pongamia Pinnata Linn

Bambrana

Sheela

2017

Asian J Pharm Clin Res

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Objective: Flavonoids from the crude seeds extract of Pongamia pinnata L., dried fruit powder of Morinda citrifolia L., bark of Mangifera indica L., and rhizome of Zingiber officinale Rosc. were screened for xanthine oxidase (XO) inhibition at different concentration. The inhibitory potential of quercetin and allopurinol were used for the determination of 50% inhibitory concentration (IC 50 ) and K i values.Methods: Isolation of flavonoids from the plant extracts was processed by column chromatography and tested for XO inhibitory activity in the range of 6-800 µg/ml. Results:The results demonstrated that optimized flavonoids extract of P. pinnata L. exhibited promising XO inhibition. P. pinnata L., M. indica L., and Z. officinale Rosc. had IC 50 in the concentration of 8.74 mM, 1.09 mM, 5.4 mM and Ki 0.35 mM, 1.73 mM, 2.7 mM, respectively. Conclusion:The study showed that plant species under investigation exhibited XO inhibition by optimized flavonoid extract. P. pinnata L. indicated promising XO inhibition compared to other plant extracts. Flavonoids can be used as a potent inhibitor of XO an alternative to allopurinol.

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Study of total phenol, flavonoids contents and phytochemical screening of various leaves crude extracts of locally grown Thymus vulgaris

Cited by 296 publications

References 12 publications

Asymmetric dumbbell-shaped silver nanoparticles and spherical gold nanoparticles green-synthesized by mangosteen (<em>Garcinia mangostana</em>) pericarp waste extracts

Asymmetric dumbbell-shaped silver nanoparticles and spherical gold nanoparticles green-synthesized by mangosteen (<em>Garcinia mangostana</em>) pericarp waste extracts

Phytochemical, Antimicrobial and Sensory Qualities of Herbal Tea Made from Sarcandra glabra and Drymis piperita

Evaluation of Xanthine Oxidase Inhibitory Activity by Flavonoids From Pongamia Pinnata Linn

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