Study of vitamin D levels and its correlation with insulin resistance

Sahasrabuddh, Anagha Vinay; Pitale, Shailesh; Gupta, Madhur; Chari, Suresh T.; Sagdeo, Mohan

doi:10.5455/njppp.2017.7.0309424042017

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…Vitamin D deficiency may also be a risk factor for IR (52) as well as the MetS (53) . However, associations of vitamin D with IR have been inconsistent (54)(55)(56) .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of vitamin D deficiency in urban south Indians with different grades of glucose tolerance

et al. 2020

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The present study assessed the prevalence of vitamin D deficiency in an urban south Indian population in individuals with different grades of glucose tolerance. A total of 1500 individuals (900 normal glucose tolerance (NGT), 300 prediabetes and 300 with type 2 diabetes mellitus (T2DM)) who were not on vitamin D supplementation were randomly selected from the Chennai Urban Rural Epidemiological Study follow-up study. Anthropometric, clinical examination and biochemical investigations (25-hydroxyvitamin D (25(OH)D), insulin, glycated Hb (HbA1c) and serum lipids) were measured. Vitamin D deficiency was defined as serum 25(OH)D < 20·0 ng/ml, insufficiency as 20–29·9 ng/ml and sufficiency as ≥30 ng/ml. Of the 1500 individuals studied, 45 % were males and the mean age was 46 (sd 12) years. Vitamin D levels lowered with increasing degrees of glucose tolerance (NGT: 21 (sd 11); prediabetes: 19 (sd 10); T2DM: 18 (sd 11) ng/ml, P < 0·001). The overall prevalence of vitamin D deficiency was 55 % and was significantly higher among individuals with T2DM (63 %) followed by prediabetes (58 %) and NGT (51 %) (Pfor trend < 0·001). Women had 1·6 times the risk of vitamin D deficiency compared with men (unadjusted OR 1·6 (95 % CI 1·3, 2·0) and adjusted OR 1·6 (95 % CI 1·2, 1·9)). However, there was no increasing trend observed with increasing age. The prevalence of abdominal obesity (66 v. 49 %), generalised obesity (80 v. 64 %), the metabolic syndrome (45 v. 37 %) and insulin resistance (38 v. 27 %) was significantly higher in those with vitamin D deficiency compared with those without. This study shows that vitamin D deficiency is highly prevalent in this urban south Indian population and was higher among individuals with T2DM and prediabetes compared with those with NGT.

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“…Vitamin D deficiency may also be a risk factor for IR (52) as well as the MetS (53) . However, associations of vitamin D with IR have been inconsistent (54)(55)(56) .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of vitamin D deficiency in urban south Indians with different grades of glucose tolerance

et al. 2020

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“…Similarly, Sahasrabuddhe et al . [ 32 ] found that obese individuals are more likely to suffer from hypovitaminosis D. Physically active individuals are more likely to go outdoors and thus have better vitamin-D levels.…”

Section: Discussionmentioning

confidence: 99%

“…Sahasrabuddhe et al . [ 32 ] found that insulin resistance is associated with vitamin-D deficiency. This may be a possible explanation of better glycemic control in patients with adequate vitamin-D levels.…”

Section: Discussionmentioning

confidence: 99%

Vitamin-D deficiency in adults of Mumbai city

Hinduja¹,

Chandy

Patkar

et al. 2022

Journal of Family Medicine and Primary Care

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Background: Vitamin-D deficiency is a pandemic that is being linked to various noncommunicable diseases. The present study is an attempt to study the demographic profile and the prevalence of comorbidities in association with the vitamin-D status of the Mumbai-based study population. The authors also attempt to understand the change in prevalence over the last decade Methodology: Fasting blood samples were collected from consenting asymptomatic adults visiting the hospital and were analyzed for the prevalence of vitamin-D deficiency and diabetes mellitus, and participants were clinically examined for the presence of hypertension (as defined by AHA guidelines) and obesity (as defined by body mass index of more than equal to 30) Results: It was found that 57% of participants were deficient, 25% had insufficient, and 18% had adequate vitamin-D levels. There were a greater number of younger ( P = 0.003) and upper-middle-class participants in the deficient group ( P = 0.043816). Prevalence of obesity, hypertension, and diabetes mellitus and the distribution of genders was comparable in the deficient and sufficient vitamin-D groups. However, diabetic vitamin-D-sufficient participants had better control of blood sugar compared to diabetic vitamin-D-deficient participants Conclusion: Although the prevalence of vitamin-D deficiency has slightly reduced compared to the previous decade, it is still highly prevalent. Diabetic vitamin-D-sufficient participants had better glycemic control compared to diabetic vitamin-D-deficient participants. Thus, it is highly recommended for primary care physicians to screen everyone for vitamin-D deficiency.

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“…In our study we did not found the similar association of VDD with prediabetes. VDD may also be a risk factor for insulin resistance [21]. However, associations of vitamin D with insulin resistance were also inconsistent [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status in Different Categories of Glucose Intolerance in Bangladeshi Adults

Hossain¹,

Shahed-Morshed²,

Fariduddin³

et al. 2021

IJDE

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Background and aims: Although vitamin D deficiency (VDD) is inversely associated with glucose intolerance, very limited data are available in Bangladesh. Thus, the study aimed to determine vitamin D status of Bangladeshi adults based on the glucose intolerance status. Materials & Methods: This cross-sectional study was carried out among 70 newly detected DM, age-group & sex-matched 76 newly detected pre-diabetes and 74 healthy control with normal glucose tolerance (NGT) based on American Diabetes Association, 2018 criteria. Participants were included consecutively from the Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU) over a period of 1 year by convenient sampling to see serum 25(OH)D which was measured by high performance liquid chromatography (HPLC) method. Results: Vitamin D levels decreased with increasing degrees of glucose intolerance [NGT: 16.82±6.57; prediabetes: 15.54±8.58; T2DM: 11.01±6.03 ng/ml, p<0.001] but significantly lower in T2DM than other two groups [T2DM vs. prediabetes, p=0.001; T2DM vs. control, p<0.001; prediabetes vs. control, p=NS]. The highest frequency of vitamin D deficiency was among individuals with T2DM (64.3%) followed by NGT (29.7%) and prediabetes (28.9%) [p<0.001]. Only HbA 1 c had predictive association with vitamin D deficiency [OR (95%CI)=2.061 (1.178, 3.608), p=0.011]. Only DM but not pre-diabetes had predictive association with vitamin D deficiency compared with NGT [DM: OR (95%CI)=4.255 (2.117, 8.552), p<0.001; prediabetes: OR (95%CI)=0.963 (0.477, 1.946), p=0.916]. Conclusion: Vitamin D level was lower and frequency of vitamin D deficiency was higher in patients with DM. Only HbA 1 c and DM had predictive association with vitamin D deficiency.

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Study of vitamin D levels and its correlation with insulin resistance

Cited by 7 publications

References 17 publications

Prevalence of vitamin D deficiency in urban south Indians with different grades of glucose tolerance

Prevalence of vitamin D deficiency in urban south Indians with different grades of glucose tolerance

Vitamin-D deficiency in adults of Mumbai city

Vitamin D Status in Different Categories of Glucose Intolerance in Bangladeshi Adults

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