An organic Rankine cycle system with a preheater, evaporator, condenser, turbine, generator, and pump was used to study its off-design performance and operational control strategy. R245fa was used as a working fluid. The net power output is 243 kW and the system thermal efficiency is 9.5% under the design conditions. For an off-design heat source flow rate (m W ), the operating pressure was controlled to meet the condition that the R245fa reached the saturation liquid and vapor states at the outlet of the preheater and evaporator, respectively. The analytical results demonstrated that the operating pressure increased with increasing m W ; a higher m W yielded better heat transfer performance of the preheater and required a smaller evaporator heat capacity; and the net power output and system thermal efficiency increased with increasing m W . The net power output increased by 64.0% while the total heat transfer rate increased by only 9.2% for the studied range of m W . To conclude, an off-design operation is studied for a heat source flow rate which varied from -39.0% to +78.0% from the designed rate, resulting in -29.2% to +16.0% and -25.3% to +12.6% variations in the net power output and system thermal efficiency, respectively.