Study on analysis of153Sm-EDTMP stability in vitro and vivo by HPLC

Bai, H. S.; Jin, Han; Fan, Honghao; Du, Jianjun; Wang, F.; Chen, D. M.; Zhang, Cheng

doi:10.1007/bf02386323

Cited by 5 publications

(1 citation statement)

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“…This seems to be in analogy to the reported 153 Sm-EDTMP characteristics. With 4 μg EDTMP, the 153 Sm-EDTMP is stable for 1 h in plasma whereas for 24 h it is stable only when using 50 μg EDTMP [29]. The trivalent metal is released from the complex very fast in vivo because of low thermodynamic and kinetic complex stability (Sm-EDTMP: log K = 14.44) [30].…”

Section: μ-Pet Measurementsmentioning

confidence: 97%

Comparison of different phosphorus-containing ligands complexing ⁶⁸Ga for PET-imaging of bone metabolism

Fellner

Riss²,

Loktionova³

et al. 2010

Radiochimica Acta

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Ga-68 / Macrocylic ligands / Phosphonates / Complex formation / Bone metastasesSummary. 99m Tc-phosphonate structures are well established tracers for bone tumour imaging. Our objective was to investigate different 68 Ga-labelled phosphonate ligands concerning labelling kinetics, binding to hydroxyapatite and bone imaging using μ-PET. Seven macrocyclic phosphoruscontaining ligands and EDTMP were labelled in nanomolar scale with n.c.a. 68 Ga in Na-HEPES buffer at pH ∼ 4. Except for DOTP, all ligands were labelled with > 92% yield. Binding of the 68 Ga-ligand complexes on hydroxyapatite was analysed to evaluate the effect of the number of the phosphorus acid groups on adsorption parameters. Adsorption of 68 Ga-EDTMP and 68 Ga-DOTP was > 83%. For the 68 Ga-NOTA-phosphonates an increasing binding with increasing number of phosphonate groups was observed but was still lower than 68 Ga-DOTP and 68 Ga-EDTMP. μ-PET studies in vivo were performed with 68 Ga-EDTMP and 68 Ga-DOTP with Wistar rats. While 68 Ga-EDTMP-PET showed uptake on bone structures, an excess amount of the ligand (> 1.5 mg EDTMP/kg body weight) had to be used, otherwise the 68 Ga 3+ is released from the complex and forms gallium hydroxide or it is transchelated to 68 Ga-transferrin. As a result, the main focus of further phosphonate structures has to be on complex formation in high radiochemical yields with macrocyclic ligands with phosphonate groups that are not required for complexing 68 Ga.

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Section: μ-Pet Measurementsmentioning

confidence: 97%

Comparison of different phosphorus-containing ligands complexing ⁶⁸Ga for PET-imaging of bone metabolism

Fellner

Riss²,

Loktionova³

et al. 2010

Radiochimica Acta

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Application of radioisotopes in the field of nuclear medicine

Nayak

Lahiri

1999

J Radioanal Nucl Chem

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A comprehensive review has been made to discuss the role of various radionuclides of lanthanide series elements in the field of nuclear medicine. The role of several pharmaceuticals labeled with radiolanthanides and used for investigative purposes like measurement of cerebral blood flow, bone density measurement, bone marrow imaging, etc., have been described. The role of lanthanide radionuclides in radiation synovectomy, radioimmunotherapy, etc., have also been discussed. Methods of preparation of some representative radiopharmaceuticals like lS3Sm-EDTMP, 153Sm-HYP, have been presented. An outline on the production of carrier free radioisotopes oflanthanide series elements has been given.

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Comparative studies on the potential use of ¹⁷⁷Lu-based radiopharmaceuticals for the palliative therapy of bone metastases

Zakaly

Mostafa

Deryabina

et al. 2020

International Journal of Radiation Biology

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Study on analysis of153Sm-EDTMP stability in vitro and vivo by HPLC

Cited by 5 publications

References 1 publication

Comparison of different phosphorus-containing ligands complexing ⁶⁸Ga for PET-imaging of bone metabolism

Comparison of different phosphorus-containing ligands complexing ⁶⁸Ga for PET-imaging of bone metabolism

Application of radioisotopes in the field of nuclear medicine

Comparative studies on the potential use of ¹⁷⁷Lu-based radiopharmaceuticals for the palliative therapy of bone metastases

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Study on analysis of153Sm-EDTMP stability in vitro and vivo by HPLC

Cited by 5 publications

References 1 publication

Comparison of different phosphorus-containing ligands complexing 68Ga for PET-imaging of bone metabolism

Comparison of different phosphorus-containing ligands complexing 68Ga for PET-imaging of bone metabolism

Application of radioisotopes in the field of nuclear medicine

Comparative studies on the potential use of 177Lu-based radiopharmaceuticals for the palliative therapy of bone metastases

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Comparison of different phosphorus-containing ligands complexing ⁶⁸Ga for PET-imaging of bone metabolism

Comparison of different phosphorus-containing ligands complexing ⁶⁸Ga for PET-imaging of bone metabolism

Comparative studies on the potential use of ¹⁷⁷Lu-based radiopharmaceuticals for the palliative therapy of bone metastases