Study on Antihypertensive and Antihyperlipidemic Effects of Marine Algae

Abstract

A total of 26 species of seaweeds (1 green, 21 brown, and 4 red algae) and 6 polysaccharides were screened for their antihypertensive and antihyperlipidemic activities using rats in order to evaluate their potential application for the prevention of cardiovascular diseases. Although diets containing some pulverized seaweeds moderately elevated total cholesterol (TC), free cholesterol (FC), and low density lipoprotein (LDL), marked antihypertensive and antihypercholesterolemic activities were found in almost all seaweeds, some of which are commonly used as food. In addition, serum levels of high density lipoprotein (HDL) were enhanced 46.0% by seaweed powder diets. Six polysaccharides derived from active 'seaweed species were investigated, and appreciable suppression of hypertension and hypercholesterolemia was observed for all samples. They also markedly enhanced the serum level of HDL.

Factors influencing efficiency of transient gene expression in the red macrophyte Porphyra yezoensis

“…In addition, Rhodophyta is used for medical purposes. The most typical example is porphyran, a sulfated polysaccharide from the cell wall of P. yezoensis and dried nori, whose physiological functions in humans are antitumor activity, antihypertensive and antihyperlipidemic activities, and macrophage stimulating activity [8][9][10]. Despite such economical and medical importance, our understanding of the molecular bases of development and physiological regulation in Rhodophyta is quite poor, which prevents progress in breeding of seaweeds.…”

Seaweed as a potential source of dietary fiber

“…Beberapa studi menunjukkan bahwa serat pangan memiliki nilai kesehatan yang penting, terutama dalam mengurangi akumulasi kolesterol dalam darah, memperbaiki penyerapan glukosa bagi penderita diabetes, mencegah penyakit kanker usus, dan membantu menurunkan berat badan (Trowel, 1976; ; Ren et al, 1994;Jones et al, 2005;Wisten & Messner, 2005). Saat ini, konsumsi serat pangan di Indonesia masih didominasi bahan asal tanaman darat karena relatif murah dan mudah diperoleh.…”

“…Konsumsi serat pangan yang cukup akan bermanf aat dalam mencegah kanker kolon, menurunkan kolesterol darah, mencegah penyakit jantung koroner, memperbaiki penyerapan glukosa bagi penderita diabetes, serta mengontrol berat badan ; Ren et al, 1994;Jones et al, 2005;Wisten & Messner, 2005). Kanker usus besar (kolon) biasanya terjadi karena kontak sel-sel mukosa usus besar dengan zat-zat karsinogen yang berasal dari makanan yang mengandung prekursor, terutama jika kontak tersebut terjadi dalam waktu yang lama dengan konsentrasi karsinogen yang tinggi.…”

“…Komponen agar diketahui dapat menurunkan kolesterol darah hingga 39% (Ren et al, 1994), sedangkan alginat mempunyai potensi dalam menurunkan kolesterol darah melalui penghambatan absorpsi kolesterol di usus ). Penelitian sejenis menunjukkan bahwa pemberian natrium alginat 200 mg/ekor/hari pada tikus selama 4 minggu mampu menurunkan kadar kolesterol total darah secara efektif signifikan (Wikanta et al, 2003).…”

Antioxidant Effect of Sargassum coreanum Root and Stem Extracts

“…큰잎모자반은 5~8 cm의 원뿔 모양의 뿌리와 뿌리 로부터 나온 5~7 mm 굵기의 원기둥 모양 중심줄기를 가지고 있으며 여러 갈래로 갈라져 가지와 잎을 낸다. 큰잎모자반에 대한 연구 결과를 보면 항암 [13], 항염증 [14], 항응고 [15], 항 고지혈, 항고혈압과 항동맥경화 [16,17] …”