Study on autonomic dysfunction and metabolic syndrome in Chinese patients

Abstract

Aims/IntroductionThere is still a lack of simple methods and instruments for the early assessment of autonomic dysfunction in metabolic syndrome patients. Assessment of sudomotor function has been proposed to explore autonomic function, and could be used as an early biomarker for metabolic syndrome. In the present study, we use a quick and non‐invasive method to measure sudomotor function, and aimed to evaluate its efficacy to identify metabolic syndrome in a Chinese population.Materials and MethodsInformation on the 1,160 Chinese participants involved in the study, such as age, sex, blood pressure, waist circumference, body mass index, fasting plasma glucose and lipid profile, and SUDOSCAN, was recorded. During the sudomotor test, patients were asked to place their bare hands and feet on large electrodes. The test took 2 min to carry out, was painless and no participant preparation was required.ResultsA total of 567 participants were diagnosed with metabolic syndrome. The prevalence of metabolic syndrome correlated significantly with increasing SUDOSCAN cardiac risk score (P for trend <0.0001). Furthermore, an increase in cardiac risk score value was associated with an increase in the number of metabolic syndrome components (P for trend <0.0001). Compared with the no‐risk group (cardiac risk score <20), participants in the high‐risk group (cardiac risk score ≥30) had a 2.83‐fold increased risk of prevalent metabolic syndrome (P < 0.0001), and 1.51‐fold increased risk (P = 0.01) after adjustments.ConclusionsAutonomic dysfunction is correlated to components of metabolic syndrome. The role of SUDOSCAN in the screening of at‐risk populations for metabolic syndrome has to be confirmed by further studies.

Cardiac Autonomic Neuropathy in Obesity, the Metabolic Syndrome and Prediabetes: A Narrative Review

“…Future research studies to address whether improvements in cardiac autonomic function are sustained with lifestyle interventions and pharmacotherapy during follow-up are required [56, 160]. The use of risk scores for CAN to guide the timing of confirmatory tests for CAN and initiation of lifestyle or pharmacotherapy interventions requires exploration [19, 161]. Further research questions are summarised in Fig.…”

Evaluating the Impact of Different Hypercaloric Diets on Weight Gain, Insulin Resistance, Glucose Intolerance, and its Comorbidities in Rats

“…Autonomic dysfunction has been linked to target organ damage, such as diastolic dysfunction, ventricular hypertrophy or cardiac remodeling, as well as with insulin resistance, hyperinsulinemia, and dyslipidemia [13,15]. It has been postulated that prevention of autonomic dysfunction could be a strategy for reducing these comorbidities and that the assessment of autonomic function could be used as an early biomarker for metabolic diseases [17,18].…”

Assessment of sudomotor function in hypertensive with/without type-2 diabetes patients using SUDOSCAN: An electrophysiological study

“…Previous studies showed that there is an association between the number of components of metabolic syndrome, including the BMI, high blood pressure, high blood sugar, and dyslipidemia with autonomic dysfunction in patients without clinical evidence of peripheral or CAN ( Zhu et al, 2016 ).…”