Study on blood glucose concentration in patients with diabetes undergoing dental extraction under local anesthesia with and without adrenaline

Haji, Irfan ul Hassan; Siddiq, Mohamed; Rao, Sripathi; Rai, Gunachandra; Hiregoudar, Jagadish S; Pitale, Unnati

doi:10.1515/jbcpp-2012-0023

Cited by 7 publications

(4 citation statements)

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“…Besides that there was no statistically significant difference in blood glucose levels of patients undergoing both treatments suggesting the clinical feasibility of epinephrine or felypressin administration for patients with this profile. The results of this study corroborate with Haji et al 14 and Khawaja et al 17 showing that the use of lidocaine associated to epinephrine does not present significant difference in the blood glucose alterations for compensated diabetic patients. In addition, Santos-Paul et al 18 conducted a study and demonstrated that epinephrine associated to lidocaine did not lead to hyperglycemia significant changes either in hemodynamics or in anxiety parameters in type 2 diabetic and coronary disease patients.…”

Section: Resultssupporting

confidence: 91%

“…Andrade 19 states that the possible complications occurring after the administration of local anesthetics with epinephrine concentrations and volumes typically used in Dentistry are much smaller than the ones often occurring in the medical clinic. Moreover, diabetic patients have shown increased tolerance to vasoconstrictive agents and may benefit from small amounts of anesthetic solutions with epinephrine at a concentration of 1: 200,000 as long as the minimum dose employed is compatible with both deep and long enough anesthesia duration 5,14,19 . This study highlights another important factor as to values observed of oximetry and heart rate, since both parameters showed no statistically significant differences between groups, considering that diabetic patients may also present hypertension 1,3,12 .…”

Section: Resultsmentioning

confidence: 99%

“…Within this context, in the dental clinic the use of anesthetics containing adrenergic vasoconstriction in diabetic patients is still controversial due to the possibility of blood glucose increase. Some authors [11][12] endorse the use of local anesthetics with epinephrine in compensated diabetic patients, however, further studies are still needed in order to assure the clinical safety of vasoconstrictor adrenergic use for this group of patients [13][14] . So far, the comparative studies of the effects of local anesthesia using prilocaine 3% associated to felypressin 0,03UI / ml (G1) and 2% lidocaine associated to epinephrine 1: 100,000 (G2) in diabetic patients is scarce.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of blood glucose in type II diabetic patients submitted to local anesthesia with different vasoconstrictors

Mello

Ramacciato

Peruzzo

et al. 2016

RGO, Rev. Gaúch. Odontol.

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ObjectiveIn the dental clinic, the use of local anesthetics containing vasoconstrictors in diabetic patients are still controversial raising some doubts. Thus, the objective of this randomized crossover clinical trial was to evaluate blood glucose, pulse oximetry and heart rate of type 2 diabetic patients when submitted to local anesthesia using prilocaine 3% associated to felypressin 0,03UI / ml (G1) and 2% lidocaine associated to epinephrine 1: 100,000 (G2). Methods The sample consisted of 20 compensated type 2 diabetic patients (both genders) who were taking oral hypoglycemic drugs. The volunteers underwent two periodontal sessions (scaling) and one of the solutions tested was used in each visit. The cited parameters were evaluated at three different times: before the procedure (T1), 10 minutes after anesthesia (T2) and after 20 minutes (T3). Results Regarding the blood glucose levels, no statistically significant difference was found in different times between G1 and G2 (p> 0.05). Similarly, regarding pulse oximetry and heart rate, no statistically significant differences were observed in intervals assessed between groups (p> 0.05), presenting values within normal limits. Conclusion RESUMOObjetivo Na clínica odontológica, o uso de soluções anestésicas locais contendo vasoconstritores em pacientes diabéticos ainda sucita algumas dúvidas. Desta forma, o objetivo deste ensaio clínico cruzado e randomizado foi avaliar de forma comparativa a glicemia, oximetria de pulso e frequência cardíaca de pacientes portadores de diabetes tipo II quando submetidos à anestesia local com prilocaína 3% com felipressina 0,03UI/ml (G1) e lidocaína a 2% com epinefrina 1:100.000 (G2). MétodosForam selecionados 20 indivíduos diabéticos do tipo II, compensados, sem distinção de gênero, que faziam uso de hipoglicemiantes orais. Os voluntários foram submetidos a duas sessões de instrumentação periodontal, sendo administrada uma das soluções testadas em cada consulta. Os parâmetros citados foram avaliados em três momentos distintos: antes do procedimento (T1), 10 minutos após a anestesia (T2) e após 20 minutos (T3). ResultadosPara os valores de glicemia não houve diferença estatisticamente significante nos diferentes tempos entre G1 e G2 (p>0,05). Da mesma forma, em relação à oximetria de pulso e frequência cardíaca, não foram observadas diferenças estatisticamente significativas nos intervalos avaliados entre os grupos (p>0,05), com valores dentro da normalidade. ConclusãoConsiderando a concentração dos vasoconstritores e o volume das soluções anestésicas empregadas, os resultados sugerem que os vasoconstritores avaliados não alteram de forma significativa a glicemia, oximetria de pulso e frequência cardíca de adultos portadores de diabetes tipo II compensados.

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Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of blood glucose in type II diabetic patients submitted to local anesthesia with different vasoconstrictors

Mello

Ramacciato

Peruzzo

et al. 2016

RGO, Rev. Gaúch. Odontol.

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show abstract

“…Numerous studies have shown that local anesthetics with adrenaline as a vasoconstrictor cause blood glucose levels to rise (2,3) . For these individuals, 3% mepivacaine without a vasoconstrictor or 3% prilocaine with 0.03 IU/mL felypressin may be advised (4,5) .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration with and Without Vasoconstrictor for Extraction of Maxillary Teeth in Diabetic Patients: Double Blind Randomized Controlled Clinical Trial

Saad¹

2023

The Egyptian Journal of Hospital Medicine

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Background: Dental extractions are routinely performed in dental offices, and the local anesthetics most frequently employed are combined with vasoconstrictors, which have undeniable benefits. Vasoconstrictors boost the quality of anesthesia, lessen toxic effects, reduce the concentration required, and reduce blood loss during surgical operations. Objective: The aim of the current study was to evaluate healing of the extraction socket and the glycemic levels before, and after injection of local anesthesia with and without vasoconstrictor in diabetic patients. Patients and methods: A total of 40 patients with controlled diabetes requiring dental extraction were randomly and equally allocated to either group A (anesthetized with Mepivacaine hydrochloride 30 mg (3%) without vasoconstrictor) or group B (anesthetized with Mepivacaine hydrochloride 20 mg (2%) with vasoconstrictor Levonordefrin hydrochloride 0.06 mg). The involved tooth was extracted in an atraumatic manner. Blood glucose level was recorded prior to and 30 minutes following extraction and healing of extraction socket was assessed at 24 hours, 4-, 7-, 14-and 21-days using Landry wound healing index. Results: Regarding healing scores results showed no statistically significant difference between groups A and B at 24 hour and 21-day period, however group A showed a statistically significant faster healing than group B at 4, 7, 14 days period with P values 0.091, 0.027 and 0.035, respectively. While results for blood glucose level showed statistically significant difference in the same group before and after local anesthesia injection (P>0.001); moreover, after administration of local anesthesia group B showed statistically significant higher blood glucose level than did group A (P=0.04). Conclusion:Vasoconstrictor present in local anesthetic elevate blood glucose level and may retard extraction socket wound healing with in the first 2 weeks following extraction; however, it is still safe to use local anesthesia with vasoconstrictor with controlled diabetic patients.

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Disorders of the Endocrine System and of Metabolism

Schifter¹,

McLean²,

Sukumar³

2021

Burket's Oral Medicine

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Study on blood glucose concentration in patients with diabetes undergoing dental extraction under local anesthesia with and without adrenaline

Abstract: Dental local anesthetic solutions containing adrenaline may safely be used in patients with diabetes who had taken their hypoglycemic medications preoperatively.

Cited by 7 publications

References 0 publications

Evaluation of blood glucose in type II diabetic patients submitted to local anesthesia with different vasoconstrictors

Evaluation of blood glucose in type II diabetic patients submitted to local anesthesia with different vasoconstrictors

Evaluation of Healing Process and Blood Sugar Level Following Local Anesthetic Infiltration with and Without Vasoconstrictor for Extraction of Maxillary Teeth in Diabetic Patients: Double Blind Randomized Controlled Clinical Trial

Disorders of the Endocrine System and of Metabolism

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