Macro-instability phenomenon in side-blown furnace was first reported in this paper, and the occurrence conditions, influencing factors and rules, eliminating measures were studied and analyzed by hydraulic experiment. The results show that the occurrence of macro-instability in side-blown furnace needs to meet certain conditions, which is mainly related to the liquid level above the jet nozzle, the number and arrangement of jet nozzles. However, the frequency macro-instability is irrelevant the nozzle height, liquid level, air flow and the nozzle diameter, the number and arrangement of jet nozzles, and the frequency of this model is 1.2Hz.The macro-instability phenomenon in side-blown furnace can be avoided or eliminated by adoption certain measures which can be used as the reference for side-blown furnace design and operation.