Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor-2 protein expression in papillary thyroid carcinoma using a quantum dot-based immunofluorescence technique

Tang, Tian; Duanlian, Zhang

doi:10.3892/etm.2015.2287

Cited by 7 publications

(6 citation statements)

References 25 publications

(24 reference statements)

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“…After a median nine-year follow-up, six patients developed metastatic disease and five of them had HER-2-positive tumors [ 77 ]. The results from Tang et al was consistent with Ruggeri’s study [ 78 ]. The positive HER-2 expression (45.71%) in PTC was significantly associated with lymph node metastatic ( p < 0.05).…”

Section: Hormones and Their Receptorssupporting

confidence: 84%

“…HER-2 is an essential marker in the molecular target and prognosis of breast cancer. HER-2 expression in TC was also debatable, varying between 0% and 83.8% [ 76 , 77 , 78 , 79 , 80 ]. In 2001, Kim et al found that HER-2 overexpression in thyroid cancer (83.8%) was more frequent than in benign tumors (16.7%), and was related to the reduction of PTEN protein [ 76 ].…”

Section: Hormones and Their Receptorsmentioning

confidence: 99%

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Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions

Liu

Zheng

et al. 2022

Cancers

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Breast and thyroid glands are two common sites of female malignancies. Since the late 19th century, physicians have found that the cancers in either thyroid or mammary gland might increase the risk of second primary cancers in the other site. From then on, many observational clinical studies have confirmed the hypothesis and more than one theory has been developed to explain the phenomenon. Since the two glands both have secretory functions and are regulated by the hypothalamic–pituitary axis, they may share some common oncogenic molecular pathways. However, other risks factors, including medical interventions and hormones, are also observed to play a role. This article aims to provide a comprehensive review of the associations between the two cancers. The putative mechanisms, such as hormone alteration, autoimmune attack, genetic predisposition and other life-related factors are reviewed and discussed. Medical interventions, such as chemotherapy and radiotherapy, can also increase the risk of second primary cancers. This review will provide novel insights into the research designs, clinical managements and treatments of thyroid and breast cancer patients.

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Section: Hormones and Their Receptorssupporting

confidence: 84%

Section: Hormones and Their Receptorsmentioning

confidence: 99%

Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions

Liu

Zheng

et al. 2022

Cancers

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“…GO and KEGG enrichment analysis, establishment of PPI network and network topological analysis were utilized to identify genes potentially related to the initiation and development of PTC. It can be hypothesized that most of the DEGs identified in the present study were enriched in multiple cancer initiation and development-related pathological processes and signaling pathways based on GO and KEGG enrichment analysis from previous research (32)(33)(34)(35)(36)(37). Recent evidence from network biology suggests that genes and proteins do not function in isolation.…”

Section: Discussionmentioning

confidence: 65%

Integrated bioinformatics analysis of the association between apolipoprotein E expression and patient prognosis in papillary thyroid carcinoma

et al. 2020

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The prognosis of most patients with papillary thyroid carcinoma (PTC) is excellent despite some cases of tumor progression or relapse. The present study was designed to reveal possible prognostic risk indicators for PTC. Differentially expressed genes (DEGs) extracted from 4 Gene Expression Omnibus (GEO) cohorts were subjected to functional enrichment analyses by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) pathway analysis. A dataset from The Cancer Genome Atlas (TCGA) was obtained to filter and validate significant genes using cytoHubba, followed by analysis of their association with clinicopathological characteristics and prognosis. In total, 240 DEGs were identified after data preprocessing. These DEGs were enriched in 'intracellular redox equilibrium', 'release of exosome', 'cell adhesion', 'regulation of extracellular matrix', 'collagen binding' and 'energy metabolism' based on GO analysis which including cellular component, molecular function and biological process. KEGG pathway analysis revealed that the DEGs were enriched in thyroid hormone synthesis, pathways in cancer, focal adhesion, metabolic pathways, apoptosis, PPAR signaling pathway and PI3K/AKT signaling pathway. Using cytoHubba, the following hub genes were identified: Apolipoprotein E (APOE); hemoglobin subunit α1 (HBA1); angiotensin II receptor 1 (AGTR1); collagen I α1 (COL1A1); galectin 3 (LGALS3) and TIMP metallopeptidase inhibitor 1 (TIMP1). The expression of these genes was found to be consistent in TCGA datasets. Kaplan-Meier analysis revealed that APOE was significantly associated with overall survival (P=0.00067) and disease free survival (P=0.00220). Additionally, low expression of APOE was significantly associated with older age (P<0.001) and higher TNM stage (P<0.001) compared with the high expression group. Therefore, APOE may function as a predictive risk indicator for progression as well as prognosis of PTC.

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“…Frequently highly overexpressed in malignancies including breast [101], stomach [102], endometrial [103,104], ovarian, uterine [105] colorectal [106], thyroid [107], urothelial [108] Medium levels in glandular cells of appendix, breast, and cervix, myocytes, respiratory epithelium, and urothelial cells [14-16] Table 5. Cont.…”

Section: Retargeting For Binding New Cancer-associated Proteinsmentioning

confidence: 99%

Prospects for Using Expression Patterns of Paramyxovirus Receptors as Biomarkers for Oncolytic Virotherapy

Matveeva¹,

Shabalina

2020

Cancers

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The effectiveness of oncolytic virotherapy in cancer treatment depends on several factors, including successful virus delivery to the tumor, ability of the virus to enter the target malignant cell, virus replication, and the release of progeny virions from infected cells. The multi-stage process is influenced by the efficiency with which the virus enters host cells via specific receptors. This review describes natural and artificial receptors for two oncolytic paramyxoviruses, nonpathogenic measles, and Sendai viruses. Cell entry receptors are proteins for measles virus (MV) and sialylated glycans (sialylated glycoproteins or glycolipids/gangliosides) for Sendai virus (SeV). Accumulated published data reviewed here show different levels of expression of cell surface receptors for both viruses in different malignancies. Patients whose tumor cells have low or no expression of receptors for a specific oncolytic virus cannot be successfully treated with the virus. Recent published studies have revealed that an expression signature for immune genes is another important factor that determines the vulnerability of tumor cells to viral infection. In the future, a combination of expression signatures of immune and receptor genes could be used to find a set of oncolytic viruses that are more effective for specific malignancies.

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Study on extracellular matrix metalloproteinase inducer and human epidermal growth factor receptor-2 protein expression in papillary thyroid carcinoma using a quantum dot-based immunofluorescence technique

Cited by 7 publications

References 25 publications

Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions

Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions

Integrated bioinformatics analysis of the association between apolipoprotein E expression and patient prognosis in papillary thyroid carcinoma

Prospects for Using Expression Patterns of Paramyxovirus Receptors as Biomarkers for Oncolytic Virotherapy

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