PurposeThis study aims to focus on the sustainability of prefabricated medical emergency buildings (PMEBs) renovation after the epidemic, to address the problem that large numbers of PMEBs may be abandoned for losing their original architectural functions. This study develops an evaluation system to identify and measure sustainable factors for PMEBs’ renovation schemes. Qualitative and quantitative analysis of PMEBs’ renovation scheme was conducted based on cloud model evaluation method and selected the renovation scheme in line with sustainable development. The study promotes evaluation methods and decision-making basis for the renovation design of global PMEBs and realizes the use-value of building functions again.Design/methodology/approachBy referring to the existing literature, design standards and expert visiting a set of evaluation index systems which combines the renovation of the PMEBs and the sustainability concept has been established, which calculates the balanced optimal comprehensive weight of each indicator utilizing combination weighting method, and quantifies the qualitative language of different PMEBs’ renovation schemes by experts through characteristics of the cloud model. This paper takes Huoshenshan hospital a representative PMEB during the epidemic period as an example, to verify the feasibility of the cloud model evaluation method.FindingsThe research results of this paper are that in the PMEBs’ renovation scheme structural reformative (T11) and corresponding nature with the original building (T13) have the most important influence; the continuity of architectural cultural value (T22) and regional development coherence (T23) are the key factors affecting the social dimension; the profitability of renovated buildings (T34) is the key factor affecting the economic dimension; the environmental impact (T41), resource utilization (T42) and ecological technology (T43) are the key factors in the environmental dimension.Originality/valueThis study contributes to the existing body of knowledge by supplementing a set of scientific evaluation methods to make up for the sustainability measurement of PMEBs’ renovation scheme. The main objective was to make renovated PMEBs meet the needs of urban sustainable development, retain the original cultural value of the buildings, meanwhile enhance their social and economic value and realize the renovation with the least impact on the environment.