Study on Hypolipidemic Activities of Safflower Seed Oil

Guo, Jian Xia; Wang, Chang Lu; Wu, Zhi Jian

doi:10.4028/www.scientific.net/amm.275-277.1640

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…It has been proved that AI is the risk factor of occurrence and development of atherosclerosis and CVDs. [ 37 ] Therefore, CSO may be used as a natural medicine to prevent and mitigate these diseases.…”

Section: Resultsmentioning

confidence: 99%

Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice

Han

Zhang

et al. 2020

Euro J Lipid Sci & Tech

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Hyperlipidemia is a common cardiovascular disease. At present, the influence of high fat diet (HFD) on this is being explored. Recently, vegetable oils rich in omega‐3 have been reported that can treat hyperlipidemia caused by HFD. However, the effects of chia seed oil (CSO) on HFD‐induced hyperlipidemia and oxidative stress are poorly studied. Hence, in this study, the effects of CSO on hyperlipidemia and oxidative stress induced by HFD in mice are analyzed by various commercial kits, section staining, and protein expression. The results show that CSO decreases body weight and organ index. Meanwhile, CSO reduces serum lipid levels of total cholesterol, triglyceride, and low‐density lipoprotein cholesterol. It can also elevate superoxide dismutase and glutathione peroxidase activities and reduce malondialdehyde content in serum and liver. The results of histopathological analysis prove that CSO improves hepatic steatosis and reduces lipid deposition. Further, the results of western blot demonstrate that CSO upregulates the expression of peroxisome proliferator‐activated receptor alpha and carnitine palmitoyltransferase 1a in the liver. As a result, CSO may be a potential lipid‐lowering oil to prevent and treat HFD‐induced hyperlipidemia and oxidative stress. Practical Applications CSO, as a byproduct of chia seed processing, is a rich source of α‐linolenic acid. This study investigates the effects of CSO on HFD‐induced hyperlipidemia and oxidative stress in mice. It is concluded that dietary CSO can improve the hyperlipidemia in HFD‐induced mice via analysis of lipid parameters, histopathology study of the liver, and lipid metabolism related genes. In addition, supplementation of CSO also can improve the oxidative stress in mice. Therefore, CSO can be used for the prevention of hyperlipidemia and oxidative stress. This research provides a theoretical basis for the comprehensive development and utilization of functional chia seed oil.

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Section: Resultsmentioning

confidence: 99%

Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice

Han

Zhang

et al. 2020

Euro J Lipid Sci & Tech

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“…Several authors in the literature have used safflower oil in rat diets and reported that there were no changes in the weights of the organs (heart, spleen, liver, lung, kidneys, stomach, intestines) that were fed the rations with this oil (TSO et al, 2012;GUO et al, 2013;APPLETON et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Thermogenic oils as a substitute for ractopamine in the production of heavy pigs

Miranda

Silva

Carmo

et al. 2022

AVB

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This study aimed to assess the effects of thermogenic oils (safflower and coconut oils) as a replacement for ractopamine in heavy pig diets. A total of 24 mix-breed barrows with an average weight of 98.70 ± 1.63 kg were distributed in a randomized block design with four treatments and six replicates. Treatments were as follows: basal diet, modified basal diet + 10 ppm ractopamine, basal diet + safflower oil, and basal diet + coconut oil. Animal performance, organ weights, meat quality, carcass traits, and economic viability were determined. Data were analyzed using Duncan’s test at the 5% significance level. The safflower oil diet resulted in the highest carcass meat and ham weights, whereas the coconut oil diet provided the highest loin eye area and the lowest fat area, resulting in the highest meat/fat ratio. Analysis of economic viability indicators revealed that vegetable oil treatments differed significantly from other treatments in feed cost, feed cost per kilogram of live weight, economic viability index, and cost index, given that oil inclusion increased the price of diets. Supplementation of heavy pig diets with thermogenic oils is a viable alternative to enhance lean meat production, but its use depends on market availability and product price.

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Discrimination of different oil types and adulterated safflower seed oil based on electronic nose combined with gas chromatography-ion mobility spectrometry

Han

Chen

et al. 2022

Journal of Food Composition and Analysis

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Study on Hypolipidemic Activities of Safflower Seed Oil

Cited by 3 publications

References 15 publications

Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice

Chia Seed Oil Prevents High Fat Diet Induced Hyperlipidemia and Oxidative Stress in Mice

Thermogenic oils as a substitute for ractopamine in the production of heavy pigs

Discrimination of different oil types and adulterated safflower seed oil based on electronic nose combined with gas chromatography-ion mobility spectrometry

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