Study on Molecular Mechanism of Yiqing Capsule in Treating Upper Respiratory Tract Infection Based on Network Pharmacology

Zhao, Yanwu; Hu, Junhui

doi:10.4236/cm.2020.111001

Cited by 2 publications

(2 citation statements)

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“…The common targets of the RPR-FC and IS were imported into the STRING database ( https://string-db.org /). [ 15 ] The species was limited to “human,” interactions were determined, and node1, node2, and combined score information were retained in the file. The above data were imported into Cytoscape 3.8 software, a PPI network diagram of the target was constructed, and the core network was screened.…”

Section: Methodsmentioning

confidence: 99%

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To explore the Radix Paeoniae Rubra-Flos Carthami herb pair's potential mechanism in the treatment of ischemic stroke by network pharmacology and molecular docking technology

Chen

Wang

et al. 2021

Medicine

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To explore the Radix Paeoniae Rubra-Flos Carthami herb pair's (RPR-FC) potential mechanism in treating ischemic stroke (IS) by network pharmacology and molecular docking technology. The Traditional Chinese Medicine Systems Pharmacology Database was used to screen the active components of the RPR-FC, and Cytoscape 3.8 software was used to construct a network map of its active components and targets of action. The GeneCards and OMIM databases were used to identify disease targets of IS, and the common targets were chosen as research targets and imported into the STRING database to construct a protein–protein interaction network map of these targets. R language software was used to analyze the enrichment of GO terms and KEGG pathways, and explore the mechanisms of these targets. Molecular docking technology was used to verify that the RPR-FC components had a good bonding activity with their potential targets. A total of 44 active components, which corresponded to 197 targets, were identified in the RPR-FC. There were 139 common targets between the herb pair and IS. GO functional enrichment analysis revealed 2253 biological process entries, 72 cellular components entries, and 183 molecular functions entries. KEGG pathway enrichment analysis was mainly related to the NF-kappa B signaling pathway, the TNF signaling pathway, apoptosis, the MAPK signaling pathway, the PI3K-Akt signaling pathway, the VEGF signaling pathway, etc. The molecular docking results showed the components that docked well with key targets were quercetin, luteolin, kaempferol, and baicalein. The active components (quercetin, luteolin, kaempferol, and baicalein) of the RPR-FC and their targets act on proteins such as MAPK1, AKT1, VEGFA, and CASP3, which are closely related to IS. 1 These targets are closely related to the NF-kappa B signaling pathway, the MAPK signaling pathway, the PI3K-Akt signaling pathway, the VEGF signaling pathway, and other signaling pathways. These pathways are involved in the recovery of nerve function, angiogenesis, and neuronal apoptosis and the regulation of inflammatory factors, which may have a therapeutic effect on IS.

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Section: Methodsmentioning

confidence: 99%

“…The common targets of the RPR-FC and IS were imported into the STRING database (https://string-db.org/) [15] . The species was limited to “human,” interactions were determined, and node1, node2, and combined score information were retained in the file.…”

Section: Methodsmentioning

confidence: 99%

To explore the Radix Paeoniae Rubra-Flos Carthami herb pair's potential mechanism in the treatment of ischemic stroke by network pharmacology and molecular docking technology

Chen

Wang

et al. 2021

Medicine

View full text Add to dashboard Cite

show abstract

Bupleurum chinense DC improves CUMS-induced depressive symptoms in rats through upregulation of the cAMP/PKA/CREB signalling pathway

Chang

Liu

et al. 2022

Journal of Ethnopharmacology

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Study on Molecular Mechanism of Yiqing Capsule in Treating Upper Respiratory Tract Infection Based on Network Pharmacology

Cited by 2 publications

References 0 publications

To explore the Radix Paeoniae Rubra-Flos Carthami herb pair's potential mechanism in the treatment of ischemic stroke by network pharmacology and molecular docking technology

To explore the Radix Paeoniae Rubra-Flos Carthami herb pair's potential mechanism in the treatment of ischemic stroke by network pharmacology and molecular docking technology

Bupleurum chinense DC improves CUMS-induced depressive symptoms in rats through upregulation of the cAMP/PKA/CREB signalling pathway

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