Study on Morphology and Function of the Drainage Area of the Eye of Man

Abstract

I n meridional sections, the anterior chamber angle is characterised by the width of the entrance into the angle, the shape of the apex, the configuration of the angle recess, and the position of the anterior part of the ciliary body. There are considerable variations in the morphology of the canal of Schlemm. The most important characteristics of the canal include the position of the sinus as regards the apex of the anterior chamber angle, the width of its lumen, and the inclination of the canal of Schlemm towards the anterior chamber. The meridional portion of the ciliary body usually reaches the scleral spur. However, in some eyes the posterior attachment of the ciliary muscle is located behind the scleral spur.In some presumably normal eyes, a partial blockage of the lumen of the Schlemm's canal was observed. Blockage was achieved experimentally on isolated eyes of man by increasing the pressure in the anterior chamber. The anterior position of the Schlemm's canal, the narrow scleral spur, and the posterior attachment of the ciliary muscle may be considered anatomical predispositions to blockage of the Schlemm's canal and the intertrabecular spaces.K e y words: anterior chamber angle -histology -aqueous.The drainage area of the eye contains the structures responsible for the outflow of the aqueous humor including the anterior chamber angle, the trabecular meshwork, the scleral spur, the canal of Schlemm and its outlets, the anterior part of the ciliary body, and the iris root.

Diagnostic power of scleral spur length in primary open-angle glaucoma

“…In addition, Nesterov et al found that the posterior SC, where received the most force from scleral spur, is wider than the anterior SC. This result also confirmed the importance of scleral spur on the morphology of SC [21]. Thus, in consideration of the close relationship between SC and scleral spur [16][17][18][19][20][21], and the close relationship between SC and aqueous humor outflow resistance [5][6][7][8][9], previous studies have suggested that short scleral spur could be engaged in the pathogenesis of POAG [16,22,23].…”

“…1a): the red solid line (a curved line bisecting the width of the scleral spur at every point) represents scleral spur length, drawn from the tip of the scleral spur to the middle of the red dotted line, which connects the anterior and posterior points where the sclera curves out to form the spur (located near the posterior end of SC, to the point where the sclera begins again). Method II (Nesterov and Batmanov [21,23,24]) ( Fig. 1b): the scleral spur length measurement (the red solid line) was taken from the tip of the scleral spur, directly to the level of the posterior end of SC.…”

Ab interno trabeculectomy: Ultrastructural evidence and early tissue response in a human eye

“…The rationale is to remove the largest portion of resistance to outflow exerted by the juxtacanalicular portion of the trabecular meshwork and the inner wall of Schlemm's canal. [3][4][5] In fact, better aqueous percolation is achieved during ab externo nonpenetrating filtering surgery by peeling the inner wall of Schlemm's canal. 6 Ab interno trabeculectomy is a novel trabecular procedure that, when associated with phacoemulsification, has been shown to produce a clinically significant decrease in IOP in eyes with a poor prognosis for filtration surgery.…”

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“…Schlemm's canal is a single endothelium-lined canal that surrounds the cornea. Schlemm's channel cells have characteristics that are similar to blood and lymphatic vessels, as well as molecular similarities between the two cell types [3]. With three views, the size of the cross section of Schlemm's canal was estimated at 1709 m; The cross-sectional area is now expected to vary between 4064 and 7164 m, with many branching water channels.…”