As the main vibration source of metro depot, the throat area has seriously affected the work and life of the occupants in over-track building. However, there are few researches on vibration mitigation of turnout. Aiming at the No. 7 single turnout with 50 kg/m rails in ballast bed, the design and effect predictions of the combined vibration mitigation with under sleeper pads (USP) and under ballast mats (UBM) is carried out through the stiffness homogenization, dynamics calculation and three-degree-of-freedom vibration calculation. The study results show that: the USP not only helps to improve the turnout stiffness irregularities longitudinally, and can significantly improve the vibration mitigation effect. When using the UBM alone, the vibration mitigation effect is optimal up to 9 dB. However, after laying the USP, the vibration mitigation effect can reach about 15 dB, which increased by 67%, and meet the vibration mitigation need in the metro depot.