Study on Small Gap Sleeve Bridging Peripheral Nerve Injury

Abstract

Epineurium or perineurium neurorrhaphy to recover the nerve continuity was the choice of peripheral nerve mutilation. The nerve selective regeneration theory was put forth by Cajal et al. As this theory was gradually accepted, many researchers had focused on it and its possible application. Our labs had centered on the small gap sleeve bridging fields for about 30 years, using autogeneic vein, artery and biogradable chitin conduits. Our goal was to improve the nerve regeneration effect by means of nerve selective regeneration theory and degradable biomaterials. This serial experiment was to confirm the possibilities of using conduit small gap sleeve bridging to substitute the traditional epineurium neurorrhaphy.

Use of Small Gap Anastomosis for the Repair of Peripheral Nerve Injury by Cutting and Sleeve Jointing the Epineurium

“…Several techniques have been described for the repair of peripheral nerve injuries, but currently reconstruction using epineurium neurorrhaphy is the most popular option. 1,2 Epineurium neurorrhaphy is the most reliable and conventional method and is accepted as the gold standard treatment for peripheral nerve injury. 3 However, epineurium neurorrhaphy has certain drawbacks, such as extraepineural axonal growth and connective tissue hyperplasia at the repair site.…”

Hedysari Extract Improves Regeneration after Peripheral Nerve Injury by Enhancing the Amplification Effect

“…The sleeve bridging method provides an appropriate room for nerve repair and regeneration, allowing the nerve to fully undergo selection and amplification in the regeneration compartment [27], [28]. Accordingly, in this study, chitin absorbable tubes were used, and the gap between the two nerve segments was kept at 2 mm (an appropriate gap for nerve regeneration and amplification).…”

Expanded 3D nanofibre sponge scaffolds by gas-foaming technique enhance peripheral nerve regeneration

“…Chitosan conduits were prepared as described previously [14]. (Please refer to Chinese patent ZL 01136314.2 for the Supplementary data technical details).…”

“…The scaffolds promoting cell adhesion and directs axon growth play the most significant role in tissue engineering. A series of biological material-based nerve grafts has been developed in the laboratory and clinic, mainly in the form of nerve conduits with different material [nerve guidance conduit (NGCs)] [14][15][16]. The degradable nerve conduit material mainly includes natural macromolecules such as collagen, chitosan, silk fibroin (SF), and synthetic polymer materials such as polylactic acid (PLA), poly(lactic-co-glycolic acid) (PLGA) and polycaprolactone (PCL) [16,17].…”