To investigate the seismic response of long-span rigid frame bridges with high-pier, the shaking table test of a 1/10 scaled rigid frame bridge model is introduced in this paper. Details about test equipment, model design, test arrangement, input ground motion waves and test principle are provided. The response of bridge model under the seismic excitation included the uniform excitation and the multi-support excitation is observed. The influence of the soil-structure interaction on the bridge is considered through the real-time dynamic hybrid testing method. The impact effect for different ground motion input during the test is discussed. The influence of multi-support excitation, soil-structure interaction and impact effect on structural seismic responses are studied based on the test results. The isolation effectiveness and the damping effect are discussed as well.