Lighting systems with circularly polarized luminescence (CPL) are an emerging field with high hopes in, for example, neural cell circuits and encoding applications. The major challenges that forfeits their realâworld application are i) the design of chiroptical materials (CMs) with high CPL brightness (BCPL; today's record is Euâbased compounds with average 287 Mâ1cmâ1, while 90% of other CMs show <150 Mâ1cmâ1 in solution) and ii) how to keep CPL response in films/coatings of technological relevance. Since natural evolution is driven by chiral selectivity at the supramolecular level, fluorescent proteins (FPs) are ideal candidates to provide large BCPL spanning visible and nearâinfrared regions. This hypothesis is confirmed for all the known FP classes, demonstrating high emission intensities (photoluminescence quantum yields (Ï) up to 76%) and record average BCPL of |200| Mâ1cmâ1 (solution). What is more, the CPL response is also kept in polymer coatings. It is rationalized that structural factors (chromophore rigidity, surrounding amino acids, supramolecular packaging, and exciton coupling) hold a significant influence, regardless of the ÏÂ values. Finally, proofâofâconcept CPLâencoded signals in monochromatic/white hybrid lightâemitting diodes with FPâpolymer filters show exceptional stabilities. Overall, this work stands out FPs toward a new CM family, in general, and biogenic CPLâencoded lighting systems, in particular.