Cooling degree-hours (CDH) received the broadest application in evaluation of the ambient air cooling efficiency in power engineering (engine intake air cooling systems) and air conditioning. The current CDH numbers are defined as a drop in air temperature multiplied by associated time duration of performance and their summarized annual number is used to estimate the annual effect achieved due to sucked air cooling in power plants based on combustion engines (fuel saving, power output increment) and in air conditioning (refrigeration energy generation according to needs). A majority of approaches to designing ambient air cooling systems is proceeding from the cooling capacity of the chillers selected to provide a maximum current or annual CDH number with corresponding maximum current or annual effect (additional energy produced or fuel consumption reduction) in site climate location. But such approaches lead to inevitable oversizing the chillers and cooling systems in the whole. The analysis of intake air cooling efficiency in site varying climatic conditions, accompanied by quite a simple numerical simulation, enabled to reveal the potential of its enhancement and evaluate numerically the results of each step of designing in logical sequence. The new approaches to cooling system rational designing were introduced, that enables to synthesize and substantiate innovative principal decisions to exclude unproductive waste of installed (design) cooling capacity in actual operation. The innovative findings of methodological approaches include the use of the rate of annual CDH number increment as an indicator for selecting the optimum and rational values of design cooling capacity. The optimum cooling capacity corresponds to maximum rate of summarized annual CDH increment and maximum level of thermal loading accordingly, which provides minimum sizes of the chiller. In reality, it is a minimum permissible value of cooling capacity of the chiller installed and the overall ambient air cooling system. The rational cooling capacity, that enables to achieve practically maximum value of annual CDH and avoid chiller oversizing, is determined as the second, local, maximum of the rate in the summarized annual CDH over the range above the first one, global, maximum. A rational design cooling capacity determined by applying the novel methodology allows to decrease the ambient air cooling system sizes by 15 to 20% compared with traditional designing issuing from the peaked thermal load during a year. With this practically a maximum annual effect in fuel saving (energy generation or others) can be achieved too.