Study on the Application of Systemic Inflammation Response Index and Platelet–Lymphocyte Ratio in Ovarian Malignant Tumors

Huang, Huifang; Wu, Kunhai; Chen, Lufei; Lin, Xiao

doi:10.2147/ijgm.s346610

Cited by 6 publications

(5 citation statements)

References 26 publications

(26 reference statements)

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“…Sun et al [ 9 ] demonstrated that a high level of SIRI (≥0.89) is an independent predictor of worse prognosis among gallbladder cancer patients. Huang et al [ 33 ] found that SIRI is useful in helping the differentiation of malignant and benign ovarian tumors, while this study did not assess the prognostic value of SIRI among ovarian tumor patients. Moreover, a recent study [ 34 ] investigated the prognostic influence of the SIRI on the survival outcomes of lung cancer patients receiving concurrent chemoradiotherapy and concluded that a high level of SIRI could independently affect the survival outcomes among those patients.…”

Section: Discussionmentioning

confidence: 79%

Levels of systemic inflammation response index are correlated with tumor-associated bacteria in colorectal cancer

Cao

Zheng

et al. 2023

Cell Death Dis

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The relationship between systemic inflammation and tumor-associated bacteria is largely unknown in colorectal cancer (CRC). The primary aim of this study was to investigate the prognostic effects of the systemic inflammation response index (SIRI) on the survival outcomes of CRC patients who experienced surgical therapy, and the second aim was to reveal the potential association between SIRI levels and tumor-associated bacteria in CRC. We recruited a cohort of 298 CRC patients who experienced surgical resection in Wuhan Union Hospital. These patients were assigned to the low and high groups based on the cut-off value of SIRI. We utilized 1:1 propensity score matching (PSM) to reduce the potential confounding factors between the low SIRI group (N = 83) and the high SIRI group (N = 83). The total DNA of 166 paraffin-embedded tumor tissues and 24 frozen tumor tissues was extracted and amplified, and 16 S rRNA sequencing was employed to uncover the composition of microbiota between low and high SIRI groups. Survival analysis uncovered that the high SIRI cohort exhibited significantly shorter overall and disease-free survival time than low SIRI companions after PSM. The ROC analyses showed that the prediction abilities of SIRI were much higher than other serum inflammatory biomarkers for survival outcomes. The microbial richness and diversity in the low SIRI group were remarkably higher than those in the high SIRI group. At the phylum level, we found that Proteobacteria, Synergistetes, WPS-2, Thermil, Fusobacteria were enriched in the high SIRI group. Cupriavidus, Thermus, Ochrobactrum, Cupriavidus, Acidovorax were enriched in the high SIRI group at the genus level. 16 S rRNA based on frozen samples also obtained similar results. SIRI is a promising and novel prognostic biomarker among CRC sufferers who underwent surgical removal. There existed significant differences in the diversity and compositions of tumor-associated bacteria between the low and high SIRI groups.

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Section: Discussionmentioning

confidence: 79%

Levels of systemic inflammation response index are correlated with tumor-associated bacteria in colorectal cancer

Cao

Zheng

et al. 2023

Cell Death Dis

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“…In patients with metastatic pancreatic cancer treated with mFOLFIRINOX, an increase in the SIRI (> 2.3) predicted a greater benefit from treatment [ 35 ]. A large number of studies have shown that the SIRI has a certain predictive effect on the prognosis of patients with gastric cancer, head and neck squamous cell carcinoma, renal cell carcinoma, ovarian cancer, and other tumours [ 36 – 39 ]. However, there are few studies on the SIRI in rectal cancer patients receiving neoadjuvant chemoradiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Predictive effect of the systemic inflammation response index (SIRI) on the efficacy and prognosis of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer

Ding,

Liu,

et al. 2024

BMC Surg

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Background Inflammation is a part of tumours, and inflammatory cells can affect the proliferation, invasion, and development of tumour cells. An increasing number of peripheral blood inflammatory markers have been found to play very important roles in the treatment and prognosis of cancer patients. The systemic inflammatory response index (SIRI) is a newer inflammatory marker, and its role in colorectal cancer, especially in locally advanced rectal cancer, is still unclear. Methods From 2015 to 2020, 198 patients with locally advanced rectal cancer (LARC) who underwent surgery following neoadjuvant chemoradiotherapy (Neo-CRT) were analysed. Patients were categorized into good- and poor- response groups according to their pathological results, and clinical characteristics and baseline parameters were compared between the two groups. The optimal cutoff values for inflammatory indicators were determined using receiver operating characteristic (ROC) analysis. Univariate and multivariate analyses were performed using the Cox proportional hazard model. Survival analysis was performed via the Kaplan‒Meier method. Results After patients were grouped into good and poor response groups, indicator differences were found in CEA, neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), and SIRI. According to the ROC analysis, the NLR (P = 0.015), SII (P = 0.001), and SIRI (P = 0.029) were significant prognostic factors. After univariate and multivariate analyses of the Cox proportional hazards regression model, only the SIRI was found to be an independent prognostic factor for overall survival (OS) and disease-free survival (DFS). Finally, Kaplan‒Meier survival curves also confirmed the ability of the SIRI to predict survival. Conclusion The preoperative SIRI can be used to predict the response to Neo-CRT in LARC patients and is an independent predictor of OS and DFS in postoperative patients. A high SIRI was associated with poor radiotherapy response and predicted poor OS and DFS.

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“…We read this study 1 with great interest. At present, due to the lack of screening and diagnosis methods for ovarian cancer, there is still a lack of early diagnosis of ovarian cancer.…”

Section: Dear Editormentioning

confidence: 99%

Letter to the Editor Concerning “Study on the Application of Systemic Inflammation Response Index and Platelet–Lymphocyte Ratio in Ovarian Malignant Tumors” [Letter]

Huang¹,

Huang²,

Wei³

2022

IJGM

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Study on the Application of Systemic Inflammation Response Index and Platelet–Lymphocyte Ratio in Ovarian Malignant Tumors

Cited by 6 publications

References 26 publications

Levels of systemic inflammation response index are correlated with tumor-associated bacteria in colorectal cancer

Levels of systemic inflammation response index are correlated with tumor-associated bacteria in colorectal cancer

Predictive effect of the systemic inflammation response index (SIRI) on the efficacy and prognosis of neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer

Letter to the Editor Concerning “Study on the Application of Systemic Inflammation Response Index and Platelet–Lymphocyte Ratio in Ovarian Malignant Tumors” [Letter]

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