Study on the chiral recognition of the enantiomers of ephedrine derivatives with neutral and sulfated heptakis(2,3-O-diacetyl)-β-cyclodextrins using capillary electrophoresis, UV, nuclear magnetic resonance spectroscopy and mass spectrometry

Studies on the chiral recognition of peptide enantiomers by neutral and sulfated β-cyclodextrin and heptakis-(2,3-di-O-acetyl)-β-cyclodextrin using capillary electrophoresis and nuclear magnetic resonance

“…In contrast, the pattern obtained for the acetylated CDs, DIAC-b-CD and HDAS-b-CD, did not provide substantial information on the complexation because the hydrogens are more or less randomly shifted. This is in accordance with results obtained for both CDs with phenethylamines [10,11,25]. However, comparing the patterns of the CICS of the acetylated CDs for the enantiomers of the dipeptides the Dd values for the corresponding diastereomeric complexes are rather different indicating the ability of the acetylated CDs to discriminate between the enantiomers.…”

“…Probably the most popular single isomer CDs are the sulfated derivatives developed by Vigh and co-workers [3][4][5][6] including heptakis-6-sulfo-b-CD (HS-b-CD) and heptakis-(2,3-di-O-acetyl-6-sulfo)-b-CD (HDAS-b-CD). The corresponding neutral single isomer 2,3-diacetyl b-CD derivative, heptakis-(2,3-di-Oacetyl)-b-CD (DIAC-b-CD), was synthesized by Takeo and co-workers [7] and Branch et al [8] and applied to the chiral separation of various analytes such as alanine b-naphthylamide [9] and a series of phenylalkylamines [10,11].…”

Simultaneous Chiral Analysis of Methamphetamine and Related Compounds by Capillary Electrophoresis/Mass Spectrometry Using Anionic Cyclodextrin

“…In recent years, anionic CDs were used in the chiral analysis of some ATS by CE. [11][12][13][14] Lurie et al 11 reported a method using sulfated(XIII)-γ-CD etc. High chiral separations of ATSs were gained (e.g.…”

Simultaneous Chiral Analysis of Methamphetamine and its Metabolites by Capillary Electrophoresis/Mass Spectrometry with Direct Injection of Urine

“…A number of CE methods have been utilized for the chiral separation of amphetamines in seized drugs etc. [13][14][15][16][17][18] and in urine. [19][20][21][22][23][24] However, these methods for amphetamines in urine require a procedure of extraction from urine and are unsatisfactory with respect to the need for rapid analyses.…”