Study on the Crystallization Rates of β‐ and ϵ‐form HNIW in in‐situ Raman Spectroscopy and FBRM

Yang, Hsiwen; Kim, Jun‐Hyung; Kim, Kwang‐Joo

doi:10.1002/prep.201900194

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…[30] Chord length distributions obtained with FBRM can be used similar to particle size distributions of laser diffraction and image analysis in different particle size ranges. [31]…”

Section: Raman Spectroscopy and Fbrmmentioning

confidence: 99%

Finding Conditions to Process Hydrate Crystals and Amorphous Solids of Disodium Guanosine 5′‐Monophosphate by an Antisolvent Crystallization Process

Kim

Ulrich

2022

Crystal Research and Technology

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A screening of amorphous, heptahydrate, and tetrahydrate forms of disodium guanosine 5′-monophosphate is investigated using an antisolvent crystallization process with the aim to selectively produce each solid form. The concentrations of the solution and solid forms are monitored by in situ Raman spectroscopy using a calibration tool. Particle sizes and particle counts are measured with elapsed time by a focal beam reflection measurement. Concentrations of amorphous and hydrates phases are determined using in-line measurement techniques. The variables studied are temperature, initial concentration, addition rate, and solvent fraction. The results demonstrate that transformation from amorphous to hydrate forms consists of four stages, which are the nucleation of the amorphous form, predissolution of amorphous form, the nucleation of hydrate crystal and dissolution of amorphous solid, and the growth of hydrate crystal. The rate-controlling step, in this case, is the dissolution of amorphous form. Transformation between heptahydrate to tetrahydrate crystals is a nucleation-growth-controlled step. It is possible to obtain selectively the solid forms of disodium guanosine 5′-monophosphate by referring to the supersaturation and solubility data.

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“…[30] Chord length distributions obtained with FBRM can be used similar to particle size distributions of laser diffraction and image analysis in different particle size ranges. [31]…”

Section: Raman Spectroscopy and Fbrmmentioning

confidence: 99%

Finding Conditions to Process Hydrate Crystals and Amorphous Solids of Disodium Guanosine 5′‐Monophosphate by an Antisolvent Crystallization Process

Kim

Ulrich

2022

Crystal Research and Technology

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“…3,4 The ε-CL-20 performs well because of its high density, detonation velocity, and excellent oxygen balance, which are much better than for the widely used nitramines 1,3,5-trinitro-1,3,5-triazine (RDX) and 1,3,5,7tetranitro-1,3,5,7-tetrazocine (HMX). 5 Unfortunately, its relatively high mechanical sensitivity brings risks in its application. 6 The polymorphic transition from the α-/β-/εphase to γupon heating would make CL-20 more sensitive, and the resulting volume expansion would decrease the mechanical strength of relevant formulations.…”

Section: Introductionmentioning

confidence: 99%

Largely desensitized and stabilized CL-20 crystals obtained through reinforcement with cross-linked graphene oxide

Huang

Wang

Zhao³

et al. 2022

CrystEngComm

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“…Supersaturation is a non-equilibrium parameter that affects the nucleation and crystal growth kinetics of the polymorphic forms [11][12][13]. Supersaturation is calculated by the solubility and real solution concentration.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Study on the Amorphous Form and Crystalline Hydrates Using in Situ Raman and FBRM

Kim

Ulrich

2021

Chem Eng & Technol

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The solubilities and maximum supersaturation concentrations of an amorphous and the crystalline tetrahydrate and heptahydrate solids of disodium guanosine 5'-monophosphate (GMP) in water-methanol mixtures were measured in situ by Raman spectroscopy and focused beam reflectance measurement. The distinct Raman peaks of the amorphous form, crystalline hydrates, solution, and solvent were used for measurements of solubility and maximum supersaturation. Above 45 °C and at methanol fractions of 0.15-0.90, the tetrahydrate was the stable form, while below 40 °C and at methanol fractions of 0.15-0.60, the heptahydrate was the stable form. Especially, the tetrahydrate was stable in the methanol fraction > 0.7 at the temperature investigated. The solubility and supersaturated concentration values can be used to selectively produce amorphous, tetrahydrate, and heptahydrate solids of GMP by anti-solvent crystallization.

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Study on the Crystallization Rates of β‐ and ϵ‐form HNIW in in‐situ Raman Spectroscopy and FBRM

Cited by 6 publications

References 21 publications

Finding Conditions to Process Hydrate Crystals and Amorphous Solids of Disodium Guanosine 5′‐Monophosphate by an Antisolvent Crystallization Process

Finding Conditions to Process Hydrate Crystals and Amorphous Solids of Disodium Guanosine 5′‐Monophosphate by an Antisolvent Crystallization Process

Largely desensitized and stabilized CL-20 crystals obtained through reinforcement with cross-linked graphene oxide

Thermodynamic Study on the Amorphous Form and Crystalline Hydrates Using in Situ Raman and FBRM

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