Study on the elastic–plastic behavior of a porous hierarchical bioscaffold used for bone regeneration

Huang, Shiping; Li, Zhiyong; Zhou, C.; Chen, Qiang; Pugno, Nicola

doi:10.1016/j.matlet.2013.08.114

Cited by 11 publications

(7 citation statements)

References 21 publications

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“…Based on a unit cell model, Li and Ramesh numerically studied the influence of particle volume characteristics on metalematrix composites over a wide stain rate region, and found that rate-dependent flow stress is affected by particle aspect ratio and particle shape [14]. Since then, various unit cell methods were successfully employed to evaluate the thermomechanical behaviors of particle-modified composites such as ceramic-particle modified polymers [15], elastoplastic behavior of porous hierarchical scaffolds [16] and thermomechanical behavior of nanocomposites [17]. The RVE method is also used to investigate the particle size dependence of the elasticeplastic stressestrain response of polymer/clay nanocomposites [18].…”

Section: Introductionmentioning

confidence: 99%

Effects of strain rate on mechanical properties of nanosilica/epoxy

Miao

Liu

Suo

et al. 2016

Composites Part B: Engineering

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Section: Introductionmentioning

confidence: 99%

Effects of strain rate on mechanical properties of nanosilica/epoxy

Miao

Liu

Suo

et al. 2016

Composites Part B: Engineering

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“…We regard this as an important complement to various activities in mechanics-based biomaterial research emerging recently on the international engineering science scene. [55][56][57][58] Thereby, related activities need not necessarily be restricted to bone tissue and its replacement, but may well span toward nonmineralized, collagen-based tissues. As could recently be shown from a collection of drying-weighing and x-ray diffraction test data [59][60][61][62] , these tissues follow general, mathematically defined composition rules related to an invariant ratio between hydration-driven fibrillar growth and the evolution of the extrafibrillar space.…”

Section: Discussion Review and Perspectivesmentioning

confidence: 99%

Quantitative intravoxel analysis of microCT-scanned resorbing ceramic biomaterials – Perspectives for computer-aided biomaterial design

et al. 2014

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Driving the field of micro computed tomography toward more quantitative, rather than qualitative, approaches, we here present a new evaluation method, which uses the unique linear relationship between gray values and x-ray attenuation coefficients, together with the energy-dependence of the latter, to identify (i) the average x-ray energy used in the CT device, (ii) the x-ray attenuation coefficients, and (iii), via the x-ray attenuation average rule, the intravoxel composition, i.e., the microporosity, which, amongst others, governs the voxel-specific mechanical properties, such as stiffness and strength. The method is realized for six 3D tricalcium phosphate scaffolds, seeded with pre-osteoblastic cells and differentiated for 3, 6, and 8 weeks, respectively. The corresponding voxel-specific microporosities turn out to increase during the culturing period (resulting in reduced elastic properties, as determined from micromechanical considerations), while the overall macroporosity remains constant. The new methods are expected to further foster the development of a rationally based and computer-aided design of biomaterials and tissue engineering scaffolds.

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“…by a directionally defected/porous material at the lowest scale, schematically shown in Figure 9, which can appropriately model various systems such as fiber-reinforced foams (Vaikhanski and Nutt, 2003), bioscaffolds (Huang et al, 2013), or the so-called nanolattices or metamaterials (Meza et al, 2014). The hollow structure considered here contains a 20% volume fraction of voids (thus reducing the overall density and increasing the specific stiffness of the matrix, as in Meza et al (2014), and is composed of overlapping "pores. "…”

Section: Simulationsmentioning

confidence: 99%

A Hierarchical Lattice Spring Model to Simulate the Mechanics of 2-D Materials-Based Composites

2015

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Citation:Brely L, Bosia F and Pugno NM (2015) It is known that structural biological materials such as bone or dentin show unprecedented damage tolerance, toughness, and strength. The common feature of these materials is their hierarchical heterogeneous structure, which contributes to increased energy dissipation before failure occurring at different scale levels. These structural properties are the key to achieve superior nanocomposites. Here, we develop a numerical model in order to simulate the mechanisms involved in damage progression and energy dissipation at different size scales in composites, which depend both on the heterogeneity of the material (defects or reinforcements) and on the type of hierarchical structure. Both these aspects have been incorporated into a 2-D model based on a Hierarchical Lattice Spring Model approach, accounting for geometrical non-linearities and including statistically based fracture phenomena. The model has been validated by comparing numerical results to linear elastic fracture mechanics predictions as well as to finite elements simulations, and then employed to study how hierarchical structural aspects influence composite material (mainly 2d, e.g., graphene based) properties, which is the main novel feature of the approach. Results obtained with the numerical code highlight the dependence of stress distributions (and therefore crack propagation) on matrix properties and reinforcement dispersion, geometry, and properties, and how the redistribution of stresses after the failure of sacrificial elements is directly involved in the damage tolerance of the material.

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Study on the elastic–plastic behavior of a porous hierarchical bioscaffold used for bone regeneration

Cited by 11 publications

References 21 publications

Effects of strain rate on mechanical properties of nanosilica/epoxy

Effects of strain rate on mechanical properties of nanosilica/epoxy

Quantitative intravoxel analysis of microCT-scanned resorbing ceramic biomaterials – Perspectives for computer-aided biomaterial design

A Hierarchical Lattice Spring Model to Simulate the Mechanics of 2-D Materials-Based Composites

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