Study on the evaluation of the use of thiabendazole in the treatment and control of bovine dermatophytosis

Abstract

A study on the use of thiabendazole in the treatment of bovine dermatophytosis caused by Trichophyton verrucosum was conducted. Fifteen infected animals were included in the study. Ten animals were treated with a thiabendazole-DMSO-salicylic acid mixture and 5 animals were left untreated as controls. The thiabendazole mixture was used topically on the skin lesions. Lesions resolved after 12 applications and 80% of the treated animals proved negative on mycological examination. All lesions healed completely after 16 applications. Thiabendazole proved to be fungicidal on specimens of skin scrapings infected with the arthroconidia and mycelial elements of the dermatophyte. The killing effect was achieved using dilutions of 1:10 000 and 1:20 000 at 4 and 7 days, respectively.

Treatment of dermatophytosis in young cattle with propolis and Whitfield's ointment

“…Furthermore, T verrucosum was isolated from only two cattle in this group at the end of the study, and there were significant differences (P<0·05) between the microscopic and mycological results in this group and the other three groups of cattle, supporting the effectiveness of the combined treatment. The results achieved in this group were comparable with the results of treatment of cattle with ringworm with topical applications of natamisin (Spanoghe and Oldenkamp 1977), thiabendazole (Gabal 1986) and an ointment containing 6 g benzoic acid, 3 g salicylic acid, 5 g sulphur, 4 g iodine and 100 g petroleum jelly (Vaseline) (Al-Ani and others 2002). In the present study, daily applications of propolis and Whitfield's ointment were highly effective in the treatment of dermatophytosis.…”

“…The disease may have a significant impact on the management and economics of affected herds (Weber 2000, Chermette and others 2008). A wide variety of treatments for the disease have been used in cattle, including chlorhexidine, salicylic acid (2 to 5 per cent), iodine-containing shampoos and tinctures, griseofulvin (Rochette and others 2003, Radostits and others 2007), thiabendazole (Gabal 1986) and ethylenediamine dihydriodide (Çam and others 2007), and vaccination against Trichophyton verrucosum is important in preventing the disease (Radostits and others 2007). However, some of these treatments have been reported to be ineffective or even toxic to the host (Kaya 2000, Rochette and others 2003).…”

Antifungal agents of use in animal health – practical applications

“…Lesions resolved after 12 applications and 80% of the treated animals proved negative on mycological examination. All lesions healed completely after 16 applications (Gabal, 1986).…”

Antifungal agents of use in animal health – chemical, biochemical and pharmacological aspects

“…For example, it proved to be fungicidal on specimens of skin scrapings infected with arthroconidia and mycelial elements of T. verrucosum . The killing effect was achieved using dilutions of 1:10 000 and 1:20 000 at 4 and 7 days, respectively (Gabal, 1986).…”