Study on the influence of crosslinking density and free polysiloxan chain length on oxygen permeability and hydrophilicity of multicomponent silicone hydrogels

Wu, Shu; Zhang, Xueqin; Sun, Ying; Yang, Hong; Lin, Baoping; Han, Xuelian; Chen, Ping

doi:10.1007/s00396-021-04850-5

Cited by 13 publications

(7 citation statements)

References 33 publications

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“…In the bare lens spectrum, the hydroxyl group absorption is detected at 3300 cm −1 and the peaks at 2959 and 1720 cm −1 are attributed to the aliphatic composition of the contact lens, as C‐H stretching and C=O stretching, respectively. The strong absorption peaks observed at 1633, 1257, and 1090 cm −1 belong to the NH, SiCH 3 , and the SiOSi groups present in the Lotrafilcon B contact lens composition, respectively 39 . The FTIR spectrum of the coated lens surface shows that the deposition process did not damage the surface composition, and the presence of the thin coating is confirmed by the slight increase in the intensity of the absorption peaks at 1720 cm −1 .…”

Section: Resultsmentioning

confidence: 77%

“…The strong absorption peaks observed at 1633, 1257, and 1090 cm À1 belong to the N H, Si CH 3 , and the Si O Si groups present in the Lotrafilcon B contact lens composition, respectively. 39 The FTIR spectrum of the coated lens surface shows that the deposition process did not damage the surface composition, and the presence of the thin coating is confirmed by the slight increase in the intensity of the absorption peaks at 1720 cm À1 .…”

Section: Characterization Of P(dmaemaco-egdma) Coating Of Contact Lensesmentioning

confidence: 84%

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Surface coatings of contact lenses for cell sheet transplantation

Dereli Can,

Tunca Atay,

Egil

et al. 2024

J of Applied Polymer Sci

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The field of corneal cell sheet engineering has evolved rapidly in the last decade; however, challenges related to transplantation into target tissue still exist, necessitating a new approach to integrate cell sheet technology onto a contact lens surface. In this study, a novel surface‐modified contact lens was developed for corneal regenerative medicine to ensure the easy and safe integration of cell sheets into the target tissue. The lens surface was coated with a thermo‐responsive polymer using the initiated chemical vapor deposition technique, facilitating the separation of tissue‐integrated cell sheets from the coated lens surface by simply lowering the temperature. BEAS‐2B and L929 cells, along with human limbal epithelial cells, were cultured on a crosslinked poly(2‐(dimethylamino)ethyl methacrylate)‐coated lens, providing temperature sensitivity for 14 days. At the end of the incubation period, the cultured cells were harvested as intact monolayer cell sheets through a simple temperature reduction, without enzymatic treatment or additional surgical procedures. Rapid and complete delamination of the cells planted and incubated on the coated lens surface was achieved at room temperature. Therapeutic contact lenses modified with cell sheet technology allowed targeted delivery of cells to the affected area of the cornea.

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Section: Resultsmentioning

confidence: 77%

Section: Characterization Of P(dmaemaco-egdma) Coating Of Contact Lensesmentioning

confidence: 84%

Surface coatings of contact lenses for cell sheet transplantation

Dereli Can,

Tunca Atay,

Egil

et al. 2024

J of Applied Polymer Sci

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“…As shown in Figure 4 b, DOE significantly increased the oxygen permeability of CS/γ-PGA/DOE hydrogel by 52%. Various size of molecules in DOE could induce skeleton network of CS/γ-PGA to form a more regular 3D network, promoting air permeability [ 66 ]. Furthermore, many skin-nourishing ingredients of DOE would have played roles in skin care if they were released from CS/γ-PGA/DOE hydrogel in the use.…”

Section: Resultsmentioning

confidence: 99%

Dendrobium officinale Enzyme Changing the Structure and Behaviors of Chitosan/γ-poly(glutamic acid) Hydrogel for Potential Skin Care

Wang

Zhang

et al. 2022

Polymers

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Hydrogels have been widespreadly used in various fields. But weak toughness has limited their further applications. In this study, Dendrobium officinale enzyme (DOE) was explored to improve chitosan/γ-poly(glutamic acid) (CS/γ-PGA) hydrogel in the structure and properties. The results indicated that DOE with various sizes of ingredients can make multiple noncovalent crosslinks with the skeleton network of CS/γ-PGA, significantly changing the self-assembly of CS/γ-PGA/DOE hydrogel to form regular protuberance nanostructures, which exhibits stronger toughness and better behaviors for skin care. Particularly, 4% DOE enhanced the toughness of CS/γ-PGA/DOE hydrogel, increasing it by 116%. Meanwhile, water absorption, antioxygenation, antibacterial behavior and air permeability were increased by 39%, 97%, 27% and 52%.

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“…Furthermore, silicone rubber obtained by cross-linking PDMS can maintain a rubber state with a low overall glass transition temperature and is used as an elastomer in the medical field. In addition, PDMS has been reported to have a high oxygen solubility coefficient. − Although it is possible to increase the oxygen supply to the corneal tissue by incorporating these characteristics of PDMS as a contact lens material, cross-linking of the PDMS surface is covered with methyl groups, resulting in a low surface energy and low affinity for water or water wettability. Water wettability of the lens surface is a prerequisite for contact lens materials …”

Section: Silicone Hydrogel As Contact Lens Materialsmentioning

confidence: 99%

Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials

Ishihara,

Shi,

Fukazawa

et al. 2023

ACS Appl. Bio Mater.

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Contact lenses are one of the most successful applications of biomaterials. The chemical structure of the polymers used in contact lenses plays an important role in determining the function of contact lenses. Different types of contact lenses have been developed based on the chemical structure of polymers. When designing contact lenses, materials scientists consider factors such as mechanical properties, processing properties, optical properties, histocompatibility, and antifouling properties, to ensure long-term wear with minimal discomfort. Advances in contact lens materials have addressed traditional issues such as oxygen permeability and biocompatibility, improving overall comfort, and duration of use. For example, silicone hydrogel contact lenses with high oxygen permeability were developed to extend the duration of use. In addition, controlling the surface properties of contact lenses in direct contact with the cornea tissue through surface polymer modification mimics the surface morphology of corneal tissue while maintaining the essential properties of the contact lens, a significant improvement for long-term use and reuse of contact lenses. This review presents the material science elements required for advanced contact lenses of the future and summarizes the chemical methods for achieving these goals.

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Study on the influence of crosslinking density and free polysiloxan chain length on oxygen permeability and hydrophilicity of multicomponent silicone hydrogels

Cited by 13 publications

References 33 publications

Surface coatings of contact lenses for cell sheet transplantation

Surface coatings of contact lenses for cell sheet transplantation

Dendrobium officinale Enzyme Changing the Structure and Behaviors of Chitosan/γ-poly(glutamic acid) Hydrogel for Potential Skin Care

Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials

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