Study on the Interaction of Yttrium(III) with Adrenaline, Noradrenaline, and Dopamine

Abstract

Yttrium(III) equilibria in the presence of catecholamines adrenaline (AD), noradrenaline (NAD), and dopamine (DP) have been investigated by potentiometric titration in aqueous solution in I ) 0.20 mol‚dm -3 KCl ionic medium and at 298.15 K. The complexation model for Y(III)-catecholamine systems has been established by the "BEST" software from the potentiometric data. The types of complexes in the yttrium(III)-catecholamine systems have been ascertained, and the protonation constants for catecholamines and the stability constants for yttrium(III) complexes with catecholamines have been obtained. The stability constants of YHL 2+ -and Y(HL) 2 +type complexes are reported. Catecholamines can form stable yttrium(III) complexes with the phenolic hydroxyl groups of catecholamines as the binding site to yttrium(III). In terms of the ligands, the stability of complexes ranks in an order such as dopamine > adrenaline > noradrenaline. The stability constants of Y(III)-adrenaline complexes are higher than their La(III) complexes due to the higher ionic potential of Y(III). The ionic radii of Ca(II) and Y(III) are roughly equal, but Y(III) has a higher charge than Ca(II). Therefore, Y(III)-catecholamine complexes are relatively more stable than Ca(II)-catecholamine complexes. This result may be utilized for in vitro and in vivo studies.

A selective fluorescence probe for yttrium(III) based on acylhydrazone Schiff base

“…However, little response in the fluorescence spectrum, upon addition of other rare earth ions, was observed even at high concentration, except the La 3+ has a little reflect. Opposite to our expect, the Y 3+ is different from the Ca 2+ , though the ionic radius of Ca 2+ and Y 3+ are roughly equal (both are 1.02 Å), that is because Y 3+ has a higher charge than Ca 2+ [12].…”

Solubility and modeling acid–base properties of adrenaline in NaCl aqueous solutions at different ionic strengths and temperatures

“…60 The knowledge of the thermodynamic aqueous properties of 61 this molecule is a very important task for pharmaceutical product 62 design, because they affect the drug efficacy, its future 63 development and formulation efforts and also influence the phar-64 macokinetics, such as the release, transport and the degree of 65 absorption in the organism. 66 The literature reports some papers (Antikainen and Witikainen,67 1973; Aydin, 2007;Bonhomme et al, 1990;Campuzano et al, 68 1975; Gao et al, 1999;Grgas-Kuznar et al, 1974;Martell and 69 Smith, 1997; Pettit and Powell, 1997) where the thermodynamic 70 properties in aqueous solution of adrenaline were investigated. 71 As already reported in a previous paper (Bretti et al, 2013), the 72 behavior of catecholamines in aqueous solution depends on many 73 parameters, such as pH, temperature, ionic medium, ionic strength 74 and on the exposure to the light and to the oxygen, since they tend 75 to oxidize quickly (Adeniyi and Wright, 2009;Bonhomme et al, 76 1990; Campuzano et al, 1975;Grant et al, 1994;Grunert and 77 Wollmann, 1982;Nagy and Takacs-Novak, 2004;Szulczewski 78 et al, 1978).…”

“…The first 243 one is a phenolic group and the second the secondary -NH 2 + group. 244 The other phenolic groups in the molecules were neglected since as 245 reported in the literature (Aydin, 2007;Pettit and Powell, 1997), 246 they are very weak acids with pK a value higher than 13. 247 According to Long and McDevit (1952), it is possible to model (Aydin, 2007;Martell et al, 2004) where a third protona-317 tion constant, with a pK a $13 associated to the second phenolic 318 group was reported and a value of pK a $13.5-14 was attributed 319 to the hydroxyl group of the alkyl chain.…”

“…244 The other phenolic groups in the molecules were neglected since as 245 reported in the literature (Aydin, 2007;Pettit and Powell, 1997), 246 they are very weak acids with pK a value higher than 13. 247 According to Long and McDevit (1952), it is possible to model (Aydin, 2007;Martell et al, 2004) where a third protona-317 tion constant, with a pK a $13 associated to the second phenolic 318 group was reported and a value of pK a $13.5-14 was attributed 319 to the hydroxyl group of the alkyl chain. In our investigation, this 320 protonation constant was neglected owing to the fact that the alka-321 limetric titrations were performed up to pH $10.5, since at higher 322 pH values the oxidation of adrenaline may occurs (Bonhomme 323 et al, 1990;Szulczewski et al, 1978).…”

“…(2) and (3) The Debye Hückel type equation (Crea et al, 2004a) used is: According to the SIT model (Brønsted, 1922;Ciavatta, 1980;452 Guggenheim and Turgeon, 1955;Scatchard, 1936), the molal activ-453 ity coefficient c i of an ion of charge z is given by: 454 log c ¼ Àz 2 0:51 (mol kg À1 (H 2 O)), the SIT approach is identical to Eq. (4): The literature reports some papers (Antikainen and Witikainen, 510 1973;Aydin, 2007;Bonhomme et al, 1990;Campuzano et al, 511 1975;Gao et al, 1999;Grgas-Kuznar et al, 1974;Martell and 512 Smith, 1997;Pettit and Powell, 1997) where the stability of adre-513 naline in aqueous solution was investigated as a function of the 514 light exposure, pH, temperature and in presence or absence of oxy-515 gen (Bonhomme et al, 1990;Grant et al, 1994;Grunert and 516 Wollmann, 1982;Nagy and Takacs-Novak, 2004;Szulczewski 517 et al, 1978). Grunert and Wollmann (1982) performing similar 518 studies on the degradation of adrenaline, reported that the process 519 is catalyzed by light, air, temperature and presence of heavy met-520 als.…”