Study on the P300 of adult epileptic patients (unmedicated and medicated patients)

Kubota, Fumio; Kifune, Akira; Shibata, Nobuyoshi; Akata, Takushirou; Takeuchi, Kazuo; Takahashi, Shigeru

doi:10.1016/s0896-6974(98)00040-1

Cited by 9 publications

(9 citation statements)

References 16 publications

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“…Consistent with many previous ERP studies [16,[30][31][32][33][34][35][36], the P3 component of the auditory ERP was recorded at the parietal midline electrode Pz. During the auditory oddball task, the processing of deviant auditory stimuli was associated with the generation of this well-characterized P3 component.…”

Section: Electrophysiological Resultssupporting

confidence: 89%

“…It is conceivable that the differential P3 modulation in responders versus nonresponders could be a consequence of different AEDs. However, this seems unlikely given the extensive evidence that AED can increase the latency of P3 components, but are not responsible for P3 amplitude modulation in both healthy adults [32] and epilepsy patients [31,33,35]. In our study, both groups took a comparable range of AEDs, and no reliable modulation of the latency of the P3 component was found depending on the experimental condition.…”

Section: Discussioncontrasting

confidence: 57%

“…(b) Scatter plot of the group of responders and nonresponders. Logistic regression analysis with VNS responder as the dependent variable and cut-off score of >20 % (horizontal line) has a sensitivity of 70 % and specificity of 90 % type and frequency of seizures, age of onset and duration of epilepsy, brain lesions, side and localization of the hypothesized epileptogenic zone, and antiepileptic drugs (AEDs) [33,35]. The strength of our approach was to compare responder and nonresponder patients with epilepsy while controlling as much as possible for potential confounding factors stemming from the heterogeneous clinical parameters and the AEDs.…”

Section: Discussionmentioning

confidence: 99%

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The P3 Event-Related Potential is a Biomarker for the Efficacy of Vagus Nerve Stimulation in Patients with Epilepsy

et al. 2014

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Currently, the mechanism of action of vagus nerve stimulation (VNS) is not fully understood, and it is unclear which factors determine a patient's response to treatment. Recent preclinical experiments indicate that activation of the locus coeruleus noradrenergic system is critical for the antiepileptic effect of VNS. This study aims to evaluate the effect of VNS on noradrenergic signaling in the human brain through a noninvasive marker of locus coeruleus noradrenergic activity: the P3 component of the event-related potential. We investigated whether VNS differentially modulates the P3 component in VNS responders versus VNS nonresponders. For this purpose, we recruited 20 patients with refractory epilepsy who had been treated with VNS for at least 18 months. Patients were divided into 2 groups with regard to their reduction in mean monthly seizure frequency: 10 responders (>50 %) and 10 nonresponders (≤50 %). Two stimulation conditions were compared: VNS OFF and VNS ON. In each condition, the P3 component was measured during an auditory oddball paradigm. VNS induced a significant increase of the P3 amplitude at the parietal midline electrode, in VNS responders only. In addition, logistic regression analysis showed that the increase of P3 amplitude can be used as a noninvasive indicator for VNS responders. These results support the hypothesis that activation of the locus coeruleus noradrenergic system is associated with the antiepileptic effect of VNS. Modulation of the P3 amplitude should be further investigated as a noninvasive biomarker for the therapeutic efficacy of VNS in patients with refractory epilepsy.

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Section: Electrophysiological Resultssupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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The P3 Event-Related Potential is a Biomarker for the Efficacy of Vagus Nerve Stimulation in Patients with Epilepsy

et al. 2014

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“…Another study indicated that the P300 was shorter in patients with epilepsy than in controls, but there was no change in the P300 component after the treatment of topiramate or VPA [ 55 ]. Kubota et al [ 42 ] used the P300 component to examine cognitive functions in patients with epilepsy (medicated and unmedicated groups). The P300 latency and amplitude were not significantly varied in the unmedicated group as well as in the control group.…”

Section: P300 and Epilepsymentioning

confidence: 99%

Application of the P300 Event-Related Potential in the Diagnosis of Epilepsy Disorder: A Review

et al. 2018

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Epilepsy is one of the most serious chronical neurological disorders, affecting more than 50 million people worldwide. It can be defined as a spectrum disorder, and patients with epilepsy possess abnormalities in cognitive functions. A number of factors can cause cognitive dysfunctions in epileptic syndromes, including etiology, the age of onset, type of seizure and severity, duration, and antiepileptic drugs. Event-related potentials (ERPs) are very useful clinical and research instruments to evaluate cognitive function in patients with neuropsychiatry disorders. Event-related potentials directly reflect cortical neuronal activity and provide a particular level of temporal resolution. Among various ERP components, the P300 is the most important component for assessing cognitive processes such as attention, working memory, and concentration. Numerous studies have reported the abnormalities in amplitude or latency of P300 component of ERP in epileptic patients, and these abnormalities are indicative of cognitive dysfunction. Therefore, the purpose of this review is to consolidate the existing literature in connection with the use of P300 in epileptic patients.

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“…The cause of such abnormalities in patients with epilepsy is unknown. Some authors believe that approximately 90% of patients present abnormal P300 latency, and that the frequency of seizures and AEDs likely contributes to the deterioration in some cases 11,12 . Due to the lesion location and electrical discharges to be related to the final point of the auditory pathway, as well as to possible specific cognitive deficits that the illness can cause, the use of complementary examinations is fundamental in order to assess the cognitive damage in epileptic subjects.…”

mentioning

confidence: 99%

Electrophysiological and auditory behavioral evaluation of individuals with left temporal lobe epilepsy

Rocha

Miziara

Manreza

et al. 2010

Arq. Neuro-Psiquiatr.

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The purpose of this study was to determine the repercussions of left temporal lobe epilepsy (TLE) for subjects with left mesial temporal sclerosis (LMTS) in relation to the behavioral testDichotic Digits Test (DDT), event-related potential (P300), and to compare the two temporal lobes in terms of P300 latency and amplitude. We studied 12 subjects with LMTS and 12 control subjects without LMTS. Relationships between P300 latency and P300 amplitude at sites C3A1,C3A2,C4A1, and C4A2, together with DDT results, were studied in inter-and intra-group analyses. On the DDT, subjects with LMTS performed poorly in comparison to controls. This difference was statistically significant for both ears. The P300 was absent in 6 individuals with LMTS. Regarding P300 latency and amplitude, as a group, LMTS subjects presented trend toward greater P300 latency and lower P300 amplitude at all positions in relation to controls, difference being statistically significant for C3A1 and C4A2. However, it was not possible to determine laterality effect of P300 between affected and unaffected hemispheres. Key words: epilepsy, event-related potentials P300, mesial temporal sclerosis.Avaliação eletrofisiológica e comportamental da audição em individuos com epilepsia em lobo temporal esquerdo resumo O objetivo deste estudo foi determinar a repercussão da epilepsia de lobo temporal esquerdo (LTE) em indivíduos com esclerose mesial temporal esquerda (EMTE) em relação à avaliação auditiva comportamental-Teste Dicótico de Dígitos (TDD), ao Potencial Evocado Auditivo de Longa Latência (P300) e comparar o P300 do lobo temporal esquerdo e direito. Estudamos 12 indivíduos com EMTE (grupo estudo) e 12 indivíduos controle com desenvolvimento típico. Analisamos as relações entre a latência e amplitude do P300, obtidos nas posições C3A1,C3A2,C4A1 e C4A2 e os resultados obtidos no TDD. No TDD, o grupo estudo apresentou pior desempenho em relação ao grupo controle, sendo esta diferença estatisticamente significante em ambas as orelhas. Para o P300, observamos que em seis indivíduos com EMTE o potencial foi ausente. Para a latência e amplitude, verificamos que estes indivíduos apresentaram uma tendência ao aumento da latência e redução da amplitude para todas as posições em relação ao grupo controle, sendo estatisticamente significante em C3A1 e C4A2. Contudo, não foi possível determinar efeito de lateralidade do P300 entre o hemisfério afetado e não-afetado. Palavras-chave: epilepsia, potencial evocado P300, esclerose mesial temporal.

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Study on the P300 of adult epileptic patients (unmedicated and medicated patients)

Cited by 9 publications

References 16 publications

The P3 Event-Related Potential is a Biomarker for the Efficacy of Vagus Nerve Stimulation in Patients with Epilepsy

The P3 Event-Related Potential is a Biomarker for the Efficacy of Vagus Nerve Stimulation in Patients with Epilepsy

Application of the P300 Event-Related Potential in the Diagnosis of Epilepsy Disorder: A Review

Electrophysiological and auditory behavioral evaluation of individuals with left temporal lobe epilepsy

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