In the seasonal frozen area of northeast China, cement concrete is usually in a working environment of cold climate and chlorine erosion coupling effect. In general, with a reasonable addition of air entraining agent (AEA) and multimineral admixtures such as fly ash, blast furnace slag, and silica fume, the durability of cement concrete under the effects of freeze-thaw and salt solution can be significantly improved in cold regions. However, due to several more compositions of cement concrete with multiple mineral admixtures, it would take excessive trial mixtures to select the desired mixture proportion based on the conventional method. This means a great deal of costs of raw materials and laboratory experimental time. In this paper, the experimental scheme of mixture proportion for air-entrained concrete with multimineral admixtures was designed based on the orthogonal experiment design method. Based on the compressive strength, rapid chloride permeability, and weight loss and relative dynamic elastic modulus after salt freeze-thaw cycles, the influence of different mineral admixtures and their dosages on the durability of concrete subjected to freeze-thaw in salt solution was analyzed. After that, based on genetic algorithm, an optimization of mixture proportion was proposed, which only requires less trial mixes and accessible optimization process. The test results indicated the superiority of air-entrained concrete with multimineral admixtures when serving in salt freeze-thaw environment. Eventually, it was also verified that the optimized concrete in this paper could achieve pleasurable durability performances under salt freeze-thaw cycles.