Study on the Pharmacokinetics Drug-drug Interaction of Danmo Capsules with Prednisone in Rats

Ren, Bin; Bing-hua, Wei; Li, Ruiming; Liang, Huamin; Hong, Xiaodan; Fu, Xiaohua; Xiao, Chen

doi:10.3923/ijp.2013.164.169

Cited by 2 publications

(4 citation statements)

References 15 publications

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“…The DMC is used in combinational therapy with prednisone to treat renal diseases, which may reduce the dosage of glucocorticoids and relieve symptoms of glucocorticoid related adverse drug effects and also significantly increased the plasma C max and AUC of glucocorticoid in rats (Ren et al, 2013). The aim was to study the tissue distribution of prednisone/prednisolone in rats after DMC was co-administered.…”

Section: Discussionmentioning

confidence: 99%

“…Previous study from our laboratory showed that the plasma C max and AUC of glucocorticoid were significantly increased, when DMC was co-administered in rats (Ren et al, 2013). However, the effect of DMC on prednisone/prednisolone tissue distribution has not yet been clarified.…”

Section: Introductionmentioning

confidence: 90%

“…The tissue distribution study was conducted in rats receiving oral administration of 42 mg kgG 1 prednisone acetate with or without 0.432 g kgG 1 dayG 1 DMC pre-treatment. The rats were then sacrificed at 0.5, 0.75 and 4 h post-dose of prednisone acetate at 14 days according to our previous research (Ren et al, 2013). The results of tissue concentration of prednisone and prednisolone were presented Table 1: Standard curves, correlation coefficients and linear ranges of prednisone and prednisolone in tissue samples (concentration of IS = 500 ng mLG 1 ) Fig.…”

Section: Tissue Distribution Studymentioning

confidence: 99%

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Tissue Distribution of Prednisone/Prednisolone is Affected by TCM Danmo Capsule in Rats

Zhang¹,

Bing-hua²,

Xia³

et al. 2015

International J. of Pharmacology

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A B S T R A C T Danmo Capsule (DMC) is a patent Chinese botanic drug, widely used in combinational therapy with prednisone in China to treat renal diseases. The combined therapy regimen can reduce the dosage of glucocorticoids and relieve symptoms of glucocorticoid related adverse drug effects. Previous study from our laboratory showed that co-administration of the DMC significantly increased the plasma C max and AUC of glucocorticoid in rats. However, the effect of DMC on prednisone/prednisolone tissue distribution remains unclear. Therefore, the purpose of the current research was to study the tissue distribution of prednisone/prednisolone in rats after DMC was co-administered. Rats were treated with control vehicle or DMC (0.432 g kgG 1 ) for 14 days before prednisone acetate (42 mg kgG 1 ) was orally given. Samples from the heart, liver, spleen, lung, kidney, brain, fat, muscle, testes, small intestine and thymus were collected at different time points. The concentrations of prednisone and prednisolone were determined by high-performance liquid chromatography. Compared with prednisone alone group, the prednisone concentrations in rat lung, kidney, heart, muscle, small intestine and fat were increased in DMC treated groups, while those in liver, spleen, brain and thymus were decreased. However, the prednisolone concentrations in liver, lung, small intestine and thymus were increased, while those in kidney, fat, muscle, testes and heart were decreased following DMC pre-treatment. These results indicated that the alteration of prednisone/prednisolone levels in important tissues, when DMC was co-administered, may contribute to the effect of DMC in reducing adverse drug reactions of glucocorticoid and lowering its dosage administered.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

Section: Tissue Distribution Studymentioning

confidence: 99%

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Tissue Distribution of Prednisone/Prednisolone is Affected by TCM Danmo Capsule in Rats

Zhang¹,

Bing-hua²,

Xia³

et al. 2015

International J. of Pharmacology

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“…Danmo Capsule is a widely used herbal preparation in China whose major constituent includes EP. This study indicated the effect of EP on changing the pharmacokinetics of glucocorticoid [ 16 ]. Unpublished data also revealed that coadministration of EP significantly increased the plasma concentration of prednisolone with decreasing level of cotreated prednisone.…”

Section: Introductionmentioning

confidence: 99%

Effect of Eclipta prostrata on 11Beta‐Hydroxysteroid Dehydrogenase in Rat Liver and Kidney

Bing-hua

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Eclipta prostrata (EP) is often prescribed in combination with glucocorticoid to treat glomerular nephritis, nephrotic syndrome, and IgA nephropathy in clinical practice of Traditional Chinese Medicine. Previous studies from our laboratory revealed that coadministration of EP significantly increased the plasma concentration of prednisolone while decreased the level of cotreated prednisone in rats. However, the underlying mechanism remains unclear. 11β-Hydroxysteroid dehydrogenase (11β-HSD) belongs to the family of oxidoreductases that catalyze the interconversion of prednisone to active prednisolone. Therefore, the current study aimed to investigate the effects of EP on the activity and expression of 11β-HSD in rat liver and kidney. The results showed that oral administration of EP significantly increased the activity of 11β-HSD I in the liver and 11β-HSD II in the kidney by employing the microsomal incubation system. Moreover, gene and protein expressions of 11β-HSD I and 11β-HSD II were also increased in rat liver and kidney, respectively. These results suggest that the effects of EP on 11β-HSD may attribute to the mechanism that administration of EP improves the efficacy and reduces adverse drug reactions of glucocorticoid in patients undergoing combinational therapy.

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Study on the Pharmacokinetics Drug-drug Interaction of Danmo Capsules with Prednisone in Rats

Cited by 2 publications

References 15 publications

Tissue Distribution of Prednisone/Prednisolone is Affected by TCM Danmo Capsule in Rats

Tissue Distribution of Prednisone/Prednisolone is Affected by TCM Danmo Capsule in Rats

Effect of Eclipta prostrata on 11Beta‐Hydroxysteroid Dehydrogenase in Rat Liver and Kidney

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