Study on the ratio of lymphocytes to epithelial cells in thymoma

Masaoka, Akira; Nagaoka, Yutaka; Maeda, Masazumi; Monden, Yasumasa; Seike, Y

doi:10.1002/1097-0142(197709)40:3<1222::aid-cncr2820400336>3.0.co;2-2

Cited by 20 publications

(1 citation statement)

References 3 publications

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“…As suggested by Masaoka [13] et al, Wychulis (Mayo Clinic) [ 141, LeGolvan [3], and Verley [ 151, thymoma with a predominance of epithelial cells has been associated with a higher local regional failure rate and hence with poorer survival. Therefore, patients with gross residual disease with a predominantly epithelial tumor may require up to 65-70 Gy to improve tumor control, provided normal tissue tolerance is respected.…”

Section: Therapy Of Thyrnomamentioning

confidence: 99%

Tumors of the thymus

Harris

Cohen

Templeton

et al. 1988

Med. Pediatr. Oncol.

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CLINICAL SUMMARYJ.V., a 40-year-old white male with a past medical history of myasthenic symptoms for 15-20 years, underwent a resection of his thymus in March 1986. He was told he had a non-invasive thymoma that required no further treatment. He did well until August 1986, when he noted left shoulder pain. Because his shoulder pain persisted, a bone scan was done in October 1986. This study revealed multiple lesions involving the left clavicle, sternum, spine at the eleventh thoracic and first lumbar vertebrae, both sacroiliac joints, the right iliac crest, and the left ischium. These findings were interpreted as being consistent with diffuse metastatic disease. The left clavicle was biopsied, with the finding of metastatic squamous cell carcinoma. A review of the patient's original thymic pathology revealed anaplastic epithelial thymic carcinoma.The question of whether metastases from a thymic carcinoma could show some degree of differentiation or whether the patient had a new primary squamous cell carcinoma, possibly of head and neck or bronchial origin, was raised. The patient was a non-smoker, had no pulmonary symptomatology, and a negative chest x-ray, so no further pulmonary work-up was pursued. He subsequently underwent biopsy of both the base of tongue and nasopharynx, with no evidence of tumor.The patient was seen in the Rush Medical Oncology Section in late October 1986. At that time he had also developed bilateral hip pain and back pain consistent with the bone scan findings. Medications included Mestinon 60 mg orally (p.0.) four to five times daily and prednisone 30 mg and 10 mg on alternate days, both prescribed for myasthenic symptoms.The physical examination showed a 40-year-old white male with a cushingoid appearance. His eyelids were drooping somewhat, though no other striking motor weahess was present on neurologic examination. The musculoskeletal assessment demonstrated bilateral sacroiliac and hip tenderness on palpation.A diagnosis of metastatic thymic carcinoma was made.He was started on Adriamycin 60 mg/m2 and cisplatin From the Section

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Section: Therapy Of Thyrnomamentioning

confidence: 99%

Tumors of the thymus

Harris

Cohen

Templeton

et al. 1988

Med. Pediatr. Oncol.

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Treatment of invasive or metastatic thymoma: Report of eleven cases

Chahinian

Bhardwaj

Meyer

et al. 1981

Cancer

103

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The clinical presentation and therapeutic modalities of 11 patients with invasive or metastatic thymoma are presented. Two patients had myasthenia gravis, and five had extrathoracic metastases. Survival exceeded five years in five patients, and four patients remain free of recurrence between 2.1 and 9.0 years after diagnosis. Surgery, with an attempt at complete resection, is the first step of therapy. A second thoracotomy for local relapse or attempt at curative resection was carried out in four patients. Radiotherapy to the mediastinum and/or metastatic sites was given to ten patients with doses ranging from 3600-6000 rads (median = 4500 rads) in the nine nonmyasthenic patients. Inclusion of supraclavicular fossae in the radiotherapy field is recommended because it was a site of relapse in two patients. Systemic therapies were given to eight patients. Objective responses were seen with two of various chemotherapeutic regimens. A combination of bleomycin, Adriamycin, cisplatin, and prednisone ("BAPP") produced a partial remission in two of five patients, during 12 and 4 months, respectively. Two of three patients responded to maytansine as a single agent after failure of other agents. Immunotherapy with intravenous Corynebacterium parvum or intradermal Methanol-Extraction Residue of bacillus Calmette-Guérin (MER-BCG) was ineffective in one patient each. The importance of combined modalities in the management of the disease is emphasized.

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Malignant, predominantly lymphocytic thymoma with central and peripheral nervous system metastases

Wick¹,

Nichols²,

Ingle³

et al. 1981

Cancer

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Histologic features of an invasive mediastinal tumor found in a 25-year-old woman fulfilled the accepted criteria for diagnosis of predominantly lymphocytic thymoma. Histochemical and cell marker studies indicated that the neoplasm contained a preponderance of T lymphocytes. After surgical debulking of the mass, aggressive radiotherapy and chemotherapy eradicated all evidence of thoracic disease. However, six months after the initial diagnosis, rapid development of cranial nerve and brainstem metastases--without detectable recurrent disease elsewhere--resulted in the patient's death. Autopsy examination revealed the presence of peripheral nerve metastases as well. A review of the literature disclosed fewer than 10 cases of central nervous system metastasis from thymoma. In only two of these were there clinicopathologic features similar to those seen in this case.

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Study on the ratio of lymphocytes to epithelial cells in thymoma

Cited by 20 publications

References 3 publications

Tumors of the thymus

Tumors of the thymus

Treatment of invasive or metastatic thymoma: Report of eleven cases

Malignant, predominantly lymphocytic thymoma with central and peripheral nervous system metastases

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