Study on the Relationship Between Bronchoalveolar Lavage Fluid Cell Count, Th1/Th2 Cytokines and Pulmonary Function in Patients with Cough Variant Asthma

Chen, Junfeng; Lin, Wei; Gu, Haiting; Ying, Kangtai; Li, Tingjian; Shao, Hongbo

doi:10.2147/jaa.s383128

Cited by 7 publications

(3 citation statements)

References 22 publications

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“…It is universally acknowledged that the deregulation of Th1/Th2 in CVA manifests predominantly as a Th2 immune response [51]. Cytokines such as IL-12 and IL-13 are deemed to play a pivotal role in the TH2-polarized immune response following inhalation of allergens.…”

Section: Discussionmentioning

confidence: 99%

Microbiota Alterations in Lung, Ileum, and Colon of Guinea Pigs with Cough Variant Asthma

Dou,

Hu,

Ding

et al. 2024

IJMS

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Alterations in the microbiota composition, or ecological dysbiosis, have been implicated in the development of various diseases, including allergic diseases and asthma. Examining the relationship between microbiota alterations in the host and cough variant asthma (CVA) may facilitate the discovery of novel therapeutic strategies. To elucidate the diversity and difference of microbiota across three ecological niches, we performed 16S rDNA amplicon sequencing on lung, ileum, and colon samples. We assessed the levels of interleukin-12 (IL-12) and interleukin-13 (IL-13) in guinea pig bronchoalveolar lavage fluid using the enzyme-linked immunosorbent assay (ELISA). We applied Spearman’s analytical method to evaluate the correlation between microbiota and cytokines. The results demonstrated that the relative abundance, α-diversity, and β-diversity of the microbial composition of the lung, ileum, and colon varied considerably. The ELISA results indicated a substantial increase in the level of IL-13 and a decreasing trend in the level of IL-12 in the CVA guinea pigs. The Spearman analysis identified a correlation between Mycoplasma, Faecalibaculum, and Ruminococcus and the inflammatory factors in the CVA guinea pigs. Our guinea pig model showed that core microorganisms, such as Mycoplasma in the lung, Faecalibaculum in the ileum, and Ruminococcus in the colon, may play a crucial role in the pathogenesis of CVA. The most conspicuous changes in the ecological niche were observed in the guinea pig ileum, followed by the lung, while relatively minor changes were observed in the colon. Notably, the microbial structure of the ileum niche approximated that of the colon niche. Therefore, the results of this study suggest that CVA development is closely related to the dysregulation of ileal, lung, and colon microbiota and the ensuing inflammatory changes in the lung.

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Section: Discussionmentioning

confidence: 99%

Microbiota Alterations in Lung, Ileum, and Colon of Guinea Pigs with Cough Variant Asthma

Dou,

Hu,

Ding

et al. 2024

IJMS

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“…CVA is a specific and atypical asthma phenotype and the most common cause of chronic cough. About 33.3% of patients with chronic cough are caused by CVA [64]. CVA is associated with airway hyperresponsiveness and chronic eosinophilic inflammation, in both central and peripheral airways, and manifests itself as a non-productive cough without wheezing or shortness of breath [65].…”

Section: Feno In Cough Variant Asthmamentioning

confidence: 99%

Exhaled Nitric Oxide as Biomarker of Type 2 Diseases

Maniscalco,

Fuschillo,

Mormile

et al. 2023

Cells

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Nitric oxide (NO) is a short-lived gas molecule which has been studied for its role as a signaling molecule in the vasculature and later, in a broader view, as a cellular messenger in many other biological processes such as immunity and inflammation, cell survival, apoptosis, and aging. Fractional exhaled nitric oxide (FeNO) is a convenient, easy-to-obtain, and non-invasive method for assessing active, mainly Th2-driven, airway inflammation, which is sensitive to treatment with standard anti-inflammatory therapy. Consequently, FeNO serves as a valued tool to aid the diagnosis and monitoring of several asthma phenotypes. More recently, FeNO has been evaluated in several other respiratory and/or immunological conditions, including allergic rhinitis, chronic rhinosinusitis with/without nasal polyps, atopic dermatitis, eosinophilic esophagitis, and food allergy. In this review, we aim to provide an extensive overview of the current state of knowledge about FeNO as a biomarker in type 2 inflammation, outlining past and recent data on the application of its measurement in patients affected by a broad variety of atopic/allergic disorders.

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“…6,28 Moreover, studies have found that cough variant asthma may have a higher wheezing threshold than asthma, 54 and although the clinical symptoms are not as severe as typical asthma, it still has an imbalance in Th1/Th2 immunity and excessive Th2 secretion in its pathogenesis. 55 In addition, Fujimura M et al 56 demonstrated similar levels of exhaled NO and cough reflex sensitivity, and bronchial responsiveness in typical asthma was higher than that in cough variant asthma. This may be related to the high percentage of sputum eosinophils that activate the cytokines of mast cells or other inflammatory cells.…”

mentioning

confidence: 97%

Bibliometric Analysis of Cough Variant Asthma from 1993 to 2022

Zhu,

Wu,

Chen

et al. 2024

JAA

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Study on the Relationship Between Bronchoalveolar Lavage Fluid Cell Count, Th1/Th2 Cytokines and Pulmonary Function in Patients with Cough Variant Asthma

Cited by 7 publications

References 22 publications

Microbiota Alterations in Lung, Ileum, and Colon of Guinea Pigs with Cough Variant Asthma

Microbiota Alterations in Lung, Ileum, and Colon of Guinea Pigs with Cough Variant Asthma

Exhaled Nitric Oxide as Biomarker of Type 2 Diseases

Bibliometric Analysis of Cough Variant Asthma from 1993 to 2022

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